Category: 152628-02-9

152628-02-9, Adding a certain compound to certain chemical reactions, such as: 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152628-02-9.

Example 3 Preparation of f4′ – [2-n-propyl-4-methyl-6-(1-methyl benzimidazol-2-vl) benzimidazol -1-vl methvll biphenvl-2-carboxvlic acidl 50 gm of [1 H – Benzimidazole-2-n – propyl-4-methyl-6-(1′-methyl benzimidazole-2′- yl) ] was added to 200 ml dimethyl sulfoxide and 50 gm of sodium hydroxide. To this was added 60 gm of methyl-4- (bromomethyl) biphenyl-2-carboxylate at ambient temperature. The contents were stirred for 2 hours at 25-30 C and then heated to 40-50 and maintained for 2 hours. About 500 ml water was added to the reaction mixture and acidified with acetic acid to pH 4.2, extract4ed twice with 250 ml of dichloromethane and the combined extracts were concentrated and isolated by filtration after addition of 300 ml acetone, dried under reduced pressure at 50-60 C to give 75.0 gm (80%) of the title compound.

According to the analysis of related databases, 152628-02-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CIPLA LIMITED; TURNER, Craig, Robert; WO2005/108375; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 152628-02-9

In a 2 litre reaction flask 500 ml of methyl isobutyl ketone was added followed by 100 gm of 2-n-propyl-4-methyl-6-( -methylbenzimidazol-2′-yl)benzimidazole. The reaction mass was stirred and a solution of 40 gm sodium hydroxide in 300 ml water was added. To this solution, 10 gm tetra butyl ammonium hydrogen sulphate and 80 gm of 4-chloromethyl-2′- cyanobiphenyl was added. The reaction mass was warmed to 80 C and maintained for 4 hours at 80 to 85 C. The completion of the reaction was monitored by TLC using mobile phase chloroform : methanol (9:1). After completion of the reaction, the mass was cooled to 20 C, maintained 3 hours at 15 to 20 C. The product which precipitated out was filtered, washed with methyl isobutyl ketone, followed by water to yield 126 gm of 2-cyano-4′-(2″-n-propyl-4″-methyl- 6″-(r”-methylbenzimidazol-2″‘-yl)benzimidazol-l”- ylmethyl) biphenyl, melting at 196 – 198 C. C 80.53%, H 5.70%, N 14.20%; m/z = 496.64 1H NMR DMSO d6 400 Mhz : 5ppm 0.96 – 0.99 (t, 3H) 1.75 – 1.84 (m, 2H) 2.62 (s, 3H) 2.89 – 2.93 (t, 2H) 3.80 (s, 3H) 5.67 (s, 2H) 7.18 – 7.92 (m, 14H)

Statistics shows that 152628-02-9 is playing an increasingly important role. we look forward to future research findings about 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5’-bibenzo[d]imidazole.

Reference:
Patent; U AMARNATH, Amarnath; U SURYAKIRAN, Suryakiran; WO2014/27280; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, 152628-02-9, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure: To a solution of 1,7′-dimethyl-2′-propyl-1H,3’H-2,5′-bibenzo[d]imidazole 3 (2 mmol) and tetrabutylammonium bromide (0.2 mmol) in benzene (25 mL), a solution of 50% NaOH (25 mL) was added at 0 C followed by the addition of sulfonyl chloride 4 (2.2 mmol). The reaction mixture was stirred vigorously at room temperature for 5-6 h and the reaction was monitored by TLC. After the completion of the reaction, aqueous phase was separated and the organic phase was washed with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulphate and concentrated to give crude products which were purified by column chromatography over silica gel using hexane-EtOAc (6:4) mixture as eluent.

Statistics shows that 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 152628-02-9.

Reference:
Article; Roopashree, Rangaswamy; Mohan, Chakrabhavi Dhananjaya; Swaroop, Toreshettahally Ramesh; Jagadish, Swamy; Raghava, Byregowda; Balaji, Kyathegowdanadoddi Srinivas; Jayarama, Shankar; Basappa; Rangappa, Kanchugarakoppal Subbegowda; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2589 – 2593;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., 152628-02-9

Example 1 Methyl 4′-((1,7′-dimethyl-2′-propyl-1H,3’H-2,5′-bibenzo[d]imidazol-3′-yl)methyl)biphenyl-2-carboxylate (V) A 1L four-necked glass vessel, fitted with mechanical stirrer, thermometer, dropping funnel, Dean-Stark apparatus, was charged with 1,7′-dimethyl-2′-propyl-1H,3H-2,5′-bibenzo[d]imidazole hydrate (II) (100 g, 310 mmol) and toluene (400 mL), under nitrogen atmosphere. The resulting mixture was heated under stirring to reflux temperature and the water was eliminated by azeotropic distillation, until a semi-solid stirrable residue was obtained. To the residue was added DMA (200 mL) and the mixture was heated to 30-40C until a complete dissolution of the residue. The resulting solution was then cooled at 0-5C, tBuONa (31 g, 322 mmol) and methyl 4′-(bromomethyl)biphenyl-2-carboxylate (IV) (97 g, 318 mmol) were added in portions. The suspension was stirred at room temperature for 2 hrs, and monitored by quantitative TLC (elution with 5% MeOH in EtOAc) until complete conversion. Water (500mL) and toluene (300 mL) were then added and the resulting solution was heated to 80C until a biphasic system was obtained. The phases were separated and the organic phase was washed with water (3 x 50 mL), dried over sodium sulphate and concentrated until a residual volume of 300 mL was reached. The solution was then quickly cooled until crystallization and the so-obtained solid was filtered and washed with toluene (2 x 40 mL). The collected product was dried at 60C under reduced pressure, affording the title compound (145 g) as a white solid. Yield: 88.4%

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Reference:
Patent; Chemo Iberica, S.A.; EP2305650; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem