Category: 152628-02-9

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Application In Synthesis of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, belongs to imidazoles-derivatives compound. In a document, author is Suwinski, J, introduce the new discover.

Synthesis of chiral imidazole derivatives as purine precursors

From commercially available chiral building blocks, we have developed methods for the syntheses of imidazole derivatives that contain a chiral alkyl substituent at ring atom. These compounds are suitable for further transformation into N-alkyl purine derivatives.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 152628-02-9. Application In Synthesis of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

In an article, author is Lauro, Figueroa-Valverde, once mentioned the application of 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, molecular weight is 304.39, MDL number is MFCD03840857, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Safety of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

Design and synthesis of some imidazole derivatives: theoretical evaluation of interaction with a coronavirus (HCoV-NL63)

Some compounds have been developed for the treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents which are dangerous and require special conditions. the objective of this investigation was to synthesize some imidazole derivatives from 2-methyl-5-nitroimidazole using some reactions such as etherification, reduction, and a hydroxy-keto derivative formation. In addition, the theoretical activity of imidazole derivatives (compounds 2, 3 and 5-8) was evaluated in a docking model using hydroxylchloroquine and favipiravir as controls. The results showed that 1) compounds 3 and 5 have a higher affinity by 5ewp protein surface compared with hydroxylchloroquine, favipiravir, 2 and 6-8. In conclusion, compounds 3 and 5 could inhibit the biological activity of coronavirus.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 152628-02-9, Safety of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

Synthetic Route of 152628-02-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is PEDERSEN, M, introduce new discover of the category.

FORMATION AND ANTIMYCOTIC EFFECT OF CYCLODEXTRIN INCLUSION COMPLEXES OF ECONAZOLE AND MICONAZOLE

The stability constants between beta-cyclodextrin (beta-CD) and the two antimycotic imidazole derivatives, miconazole and econazole were measured. Increased ionization of the imidazole derivatives decreased the size of the stability constants. The same phenomenon was observed for miconazole and hydroxypropyl-beta-cyclodextrin. In addition, the type of solubility diagram obtained was dependent on the degree of ionization of the imidazole derivatives. A type Bs solubility diagram was obtained for econazole and beta-CD in buffer solution, pH 7.1. An econazole beta-CD complex with a molar ratio of 1:1 was isolated. In a fluid medium the antimycotic effect of the econazole beta-CD complex against a strain of Candida albicans was superior to the effect of a physical mixture of the two compounds. A small inhibitory effect of beta-CD on the growth of the test organism was observed.

Synthetic Route of 152628-02-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 152628-02-9.

Reference of 152628-02-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 1,7′-dimethyl-2′-propyl-1H,3’H-2,5′-bibenzo[d]imidazole 3 (2 mmol) and tetrabutylammonium bromide (0.2 mmol) in benzene (25 mL), a solution of 50% NaOH (25 mL) was added at 0 C followed by the addition of sulfonyl chloride 4 (2.2 mmol). The reaction mixture was stirred vigorously at room temperature for 5-6 h and the reaction was monitored by TLC. After the completion of the reaction, aqueous phase was separated and the organic phase was washed with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulphate and concentrated to give crude products which were purified by column chromatography over silica gel using hexane-EtOAc (6:4) mixture as eluent.

The synthetic route of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Roopashree, Rangaswamy; Mohan, Chakrabhavi Dhananjaya; Swaroop, Toreshettahally Ramesh; Jagadish, Swamy; Raghava, Byregowda; Balaji, Kyathegowdanadoddi Srinivas; Jayarama, Shankar; Basappa; Rangappa, Kanchugarakoppal Subbegowda; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2589 – 2593;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 152628-02-9 as follows. HPLC of Formula: C19H20N4

4-Methyl-6-(l -methyl benzimidazol-2-yl)-2-n-propyl lH-benzimidazole (50gms) is suspended in acetone (500 ml), aqueous potassium hydroxide solution (13.8 gms in 31.4 ml of water) is added and mixed for 30 min at temperature of 25 – 3O0C. The mass is cooled, t-Butyl 4″-(bromomethyl)-2-biphenyl-2-carboxylate (50 gms) slowly added over 30 min and maintained the reaction mass at temperature of 0 – 50C for 6 hrs. The solvent is distilled off from the reaction mass at temperature below 5O0C under vacuum. Water (500 ml), Methylene chloride (300 ml) is added to the residue and mixed for about 15 min. pH of the reaction mass is adjusted with hydrochloric acid to 1.8 at temperature of 20 – 250C. Reaction mass is allowed to settle, layers are separated, aqueous layer is extracted with methylene chloride (100 ml). Combined organic layer is washed water (100 ml), treated with charcoal (5 gms) and dried the organic layer over anhydrous sodium sulphate (10 gms). Solvent is distilled off from the dried organic layer at EPO temperature below 50upsilonC finally under vacuum. Acetone (100 ml) is added to the residue,* mixed for about 10 min and solvent is distilled off under vacuum at temperature below5O0C. Acetone (300 ml) is added to the residue, cooled the mass to 3O0C and pH of the mass is adjusted to 2.8 with IPA HCl (about 2 ml). Temperature of reaction mass is raised, maintained for 1 lir at reflux temperature, cooled and maintained for 30 min at 25- 3O0C. Product is filtered, wet cake is washed with acetone (50 ml) and dried the wet cake at temperature of 60 – 7O0C till becomes constant weight.The Dry weight of tert Butyl 4Lambda-[4-Methyl-6-(l-methyl-lH-benzimidazol-2-yl)-2-n- propyl- lH-benzimidazol-l-yl-methyl]biphenyl-2-carboxylate hydrochloride is 73 gms (Yield: 73%). HCl content: 5.85 % w/w

According to the analysis of related databases, 152628-02-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MATRIX LABORATORIES LIMITED; WO2007/10558; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 152628-02-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of I (30.4 g, 0.10 mol), the title compound 4′-chloromethylbiphenyl-2-carbonitrile (0.12 mol) of Example 14, Sodium ethoxide (or other organic bases as described above) (0.3 mol) Mixed with DMF (or other solvents as previously described) (200 ml) and reacted at 65 C for about 5 hours. After TLC was tested for no material, ethylene glycol (100 ml and water (50 ml) (Or other aqueous solvent) and heated to 160 C. TLC detection of no raw materials, the ice water to adjust the concentration of concentrated hydrochloric acid to 5 to 6, The solid was precipitated and the resulting solid was filtered, washed with water, telmisartan crude product, by recrystallization of telmisartan.

The synthetic route of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Specialization Pharmaceutical Technology Co., Ltd.; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shandong Tefaman Pharmaceutical Co., Ltd.; Wu Mingjun; Li Jianfeng; Chen Weiming; Tian Guanghui; Zhu Fuqiang; Suo Jin; Shen Jingshan; (14 pag.)CN104768936; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 152628-02-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 3: Alkylation of (2-(1-propyl)-4-methyl-6-(1′-methylbenzimidazole-2-il)benzimidazole); [Show Image] 15 mL of sulfolane (tetramethylene sulfone) is charged to the flask. 0.85 g of PMB (2-(1-propyl)-4-methyl-6-(1′-methylbenzimidazole-2-il)benzimidazole) and 0.38 g of potassium tert-butoxide are added. The mixture is heated above 30 C to dissolve all the components. The solution is than cooled down to 15 C and 1.07 g of 4′-bromomethyl-2-iodo-biphenyl in 5 mL of solvent is added slowly during 45 minutes. The reaction mixture is stirred at the same temperature for additional 2 hours. 40 mL of demineralised water and 35 mL of EtOAc (ethyl acetate) are added. The phases are separated. The upper EtOAc phase is washed several times with saturated water solution of NaCl. The solvent is evaporated and 4 mL mixture of EtOAc and acetone is added. The suspension is stirred for 30 minutes at room temperature. The suspension is filtered and 0.94 g of white crystals of 3′-(2′-iodo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1 H,3’H-[2,5′]bibenzimidazolyl are obtained. 1H NMR (300 MHz, CDCl3) delta: 1.06 (t, J = 7.4 Hz, 3H), 1.84 – 1.92 (m, 2H), 2.95 (t, J = 7.8 Hz, 2H), 3.81 (s, 3H), 5.46 (s, 2H), 7.03 (ddd, J = 7.9 Hz, J = 7.4 Hz, J = 1.8 Hz, 1H), 7.13 (d, J = 8.0 Hz, 2H), 7.23 – 7.54 (m, 9H), 7.77 – 7.83 (m, 1H), 7.94 (dd, J = 7.9 Hz, J = 1.1 Hz, 1H).

The synthetic route of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lek Pharmaceuticals D.D.; EP2103588; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152628-02-9, Recommanded Product: 152628-02-9

The double-benzimidazole heterocyclic compound (500 mg, 1 . 64mmol) soluble in 20mLN, in N – dimethyl formamide, adding sodium hydrogen (79 mg, 3 . 3mmol) at room temperature under stirring 30min, slow the instillment contains N – O-cyano phenyl -4 – bromo methyl indole (560 mg, 1 . 8mmol) of N, N – dimethyl formamide solution (10 ml) in. The mixed liquid continuing stirring at room temperature instead on invitation 2h, TLC monitoring to the reaction is complete. Filtering, the filter cake is dichloromethane (10 ml ¡Á 3) washing three times. In the filtrate by adding 200 ml of methylene chloride and 200 ml water, takes organically. After the dichloromethane (150 ml ¡Á 3) extracting the aqueous phase three times, the combined organic phase. For saturated salt water (300 ml ¡Á 4) washing the organic phase four. For drying the organic phase with anhydrous magnesium sulfate, filter, evaporate the solvent under reduced pressure, to obtain amber solid. The solid weight crystallized to obtain gray solid about 600 mg (yield is about 68.3%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chen, Zhilong; Zhu, Weibo; Ren, He; Yan, Yijia; Bao, Xiaolu; Chen, Danye; (16 pag.)CN106467521; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, 152628-02-9, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

10 g (0.0329 mol) of 2-propyl-4-methyl-6-(r-methylbenzimidazole-2- yl)benzimidazole (1) was dissolved in 60 ml of dimethylsulfoxide (DMSO). 3.7 g (0.0329 mol) of Potassium tert-butoxide was added to the aforementioned solution and stirred at room temperature (25-3O0C) for 30 min. Afterwards, 11.45 g (0.0329 mol) of tert-Butyl-4-bromomethylbiphenyl-2-carboxylate (2) was added and the obtained mixture was stirred at room temperature (25-3O0C) for 3 h. At this stage, the reaction was quenched with water (400 ml) and stirred for 30 min. The reaction mass was filtered. The resulting wet cake was slurried in water (200 ml) and stirred for 30 min. The reaction mass was filtered and the obtained solid was dried under vacuum at 60-650C until constant weight. 18.3 g obtained (93% HPLC).

Statistics shows that 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 152628-02-9.

Reference:
Patent; INKE, S.A.; SINGH, Santosh; JOSHI, Anil; NEWADKAR, Ravindranath; WO2010/149565; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

152628-02-9, A common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 500 mL four-necked flask equipped with a mechanical stirrer and a thermometer, 30.0 g (98.6 mmol) of 2-n-propyl-4-methyl-6- (1′-methylbenzimidazol-2-yl) benzimidazole, 124 g of methylpyrrolidone and 11.1 g (98.9 mmol) of potassium tert-butoxide were added and stirring was started. While cooling the 4-necked flask with ice water, a solution of 33.1 g (108.5 mmol) of 4′-bromomethylbiphenyl-2-carboxylic acid methyl ester in 124 g of N-methylpyrrolidone was heated at an internal temperatureWas added dropwise at 0 to 10 C. over 25 minutes.After the dropwise addition, the mixture was stirred at an internal temperature of 0 to 10 C. for 3 hours.The reaction solution was sampled and analyzed by HPLC. As a result, 2-n-propyl-4-methyl-6- (1′-methylbenzimidazol-2-yl) benzimidazole was not detected and 82.5%4 ‘- [[4-methyl-6- (1 -methyl- 1 H- benzimidazol-2-yl) -2-propyl- 1 H- benzimidazol- 1 – yl] methyl] biphenyl- there were.150 g of water and 130 g of toluene were placed in a 1000 mL four-necked flask equipped with a mechanical stirrer, and while stirring,A reaction solution of a 500 mL four-necked flask was added dropwise.30 g of 35% hydrochloric acid was added to acidify the aqueous layer, and the organic layer and the aqueous layer were separated.209 g of toluene and 46 g of 25% sodium hydroxide aqueous solution were added to the aqueous layer,The aqueous layer was made alkaline and separated into an organic layer and an aqueous layer.An aqueous layer and 78 g of toluene were put into a 500 mL separating funnel and extracted,It was separated into an organic layer and an aqueous layer.The organic layers were combined and concentrated,A solution of 4 ‘- [[4-methyl-6- (1 -methyl- 1 H- benzimidazol-2-yl) -2- propyl- 1 H- benzimidazol- 1 – yl] methyl] biphenyl- 63.3 g of crude product was obtained. This crude product contained about 13.5 g of toluene, and the content of the target product was 49.8 g (yield 95.6%).

The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DNP FINE CHEMICALS UTSUNOMIYA COMPANY LIMITED; MATSUMOTO, TAKAFUMI; IKEDA, SHIN; SUZUKI, YOSHINOBU; (12 pag.)JP5711888; (2015); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem