Category: 152628-02-9

Electric Literature of 152628-02-9,Some common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a container equipped with a thermometer, a stirrer, and a condenser, 2-n-propyl-4-methyl-6- (1?-methylbenzimidazol-2-yl) benzimidazole (purity 94.4%) 30. 0 part by weight and 124 parts by weight of N-methyl-2-pyrrolidone were charged and dissolved at 20-25 C. with stirring. Next, 11.1 parts by weight of t-butoxypotassium was charged at 20-30 C. over about 30 minutes, and then cooled to 2-5 C.In this mixed solution, 124 parts by weight of N-methyl-2-pyrrolidone and 33.1 parts by weight of 4?-bromomethylbiphenyl-2-carboxylic acid methyl ester were charged and dissolved at 15 to 20 C. with stirring. The total amount of 157.1 parts by weight of N-methyl-2-pyrrolidone solution containing 4?-bromomethylbiphenyl-2-carboxylic acid methyl ester was added dropwise over a period of 30 minutes in the range of 2 to 5 C. The mixture was kept at the same temperature for about 3 hours to obtain a reaction mixture of telmisartan methyl ester (I). Thereafter, the mixture is heated to about 55 C., and then 211 parts by weight of water is added dropwise in the range of 50 to 55 C. over about 1 hour to precipitate crystals, and then kept at the same temperature for 3 hours. The solution was cooled to 0 C., filtered, washed with methanol water, and dried at 50 C./1 kPa to obtain 42.8 parts by weight of telmisartan methyl ester (I) crystals. The crystals were analyzed by liquid chromatography.

The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 152628-02-9,Some common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound c, represented by Formula 3, was synthesized using Compound a and Compound b purified in Example 1-1. Lithium tert-butoxide was reacted in an inexpensive t-BuOH (tert-butyl alcohol) solvent to obtain compound c in a yield of 54%. As a result of comparing various base conditions such as pyridine, DMAP, Et3N, K2CO3, KOAc, NaOEt, NaH, and Na / MeOH, Compound c was obtained in a yield of 66% at a room temperature of Na / MeOH and 71% at 70 C. Also, a reaction of 1 g scale was carried out to synthesize compound c in the final 70% yield. Then, in order to hydrolyze the obtained compound c, hydrolysis optimum reaction conditions were searched under various acid or base conditions.The reaction was detected in the acid hydrolysis conditions of HCl / CH2Cl2 or H2SO4 / H2O, but the yield was not improved, and the hydrolysis reaction was carried out using the base conditions.The reaction was optimized using sodium hydroxide (NaOH) and THF, DMSO, toluene or H2O solvent, and 3N NaOH / THF at 100 was selected. As a result, telmisartan, a compound represented by the following formula (4), was obtained in a yield of 93%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, its application will become more common.

Synthetic Route of 152628-02-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 152628-02-9 name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

32.24 g of 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2′-yl)benzimidazole x H2O is placed in 100 mL of dimethylacetamide (DMA), and 11.8 g of potassium tert-butoxide is added batchwise with stirring at approximately 20 C. and then the mixture is stirred for one hour at about 20 C. The mixture is cooled to 5 C. and then a mixture of 28.6 g of 4-bromomethyl-2′-cyanobiphenyl and 95 mL of DMA (dissolved at approximately 20 C.) is added dropwise over about 30 minutes. The temperature of the reaction mixture is maintained at approximately 5 C.-10 C. by cooling with the ice bath. Then it is rinsed with 5 mL of DMA and stirred for a further 1.5 hours at 5 C. to 10 C. [0045] The solvent is largely distilled off under a water-jet vacuum, during which time the product crystallizes out. The residue is cooled to 60 C., diluted with 230 mL of tert-butylmethylether and stirred for 1 hour without any energy input, then cooled to 15 C. to 20 C. and stirred for another hour at this temperature. The crystals are suction filtered, washed batchwise with 100 mL of tert-butylmethylether, then with 250 mL of water, and then dried in a vacuum drying cupboard at 80 C. Yield: 43.3 g (87.5% of theory); melting point: 196 C.-197 C.; HPLC: >99.9%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2004/236113; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4. In an article, author is Wang, Jinchang,once mentioned of 152628-02-9, Application In Synthesis of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

Electrochemical and Theoretical Study of Imidazole Derivative as Effective Corrosion Inhibitor for Aluminium

The corrosion inhibition performance of 2-styryl-1,8-dihydro-1,3,8-triaza-cyclopentaindene (IIZ) on Aluminium in 1M HCl was investigated by electrochemical impedance spectroscopy (EIS), Potentiodynamic polarization, scanning electron microscopy (SEM), atomic force microscopy (AFM), and quantum chemical techniques. Potentiodynamic polarization study confirmed that IIZ is mixed type inhibitor with cathodic predominance. SEM and AFM confirm the formation of an adsorption film on the aluminium surface. Quantum chemical study reveals that protonated IIZ interacts more than neutral IIZ. The theoretical data obtained are in agreement with experimental results.

Interested yet? Keep reading other articles of 152628-02-9, you can contact me at any time and look forward to more communication. Application In Synthesis of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

Application of 152628-02-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is Wan, Li, introduce new discover of the category.

Synthesis, characterization, and electrochemical properties of imidazole derivatives functionalized single-walled carbon nanotubes

The imidazole derivatives functionalized single-walled carbon nanotubes (SWNTs) were synthesized by a diazonium-based reaction. We have designed and synthesized two imidazole derivatives to modify SWNTs. The resulting products were characterized by Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, ultraviolet visible (UV/Vis) spectroscopy, thermo gravimetric analysis (TGA), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Electrochemical measurements via a cyclic voltammetry method revealed that the weak intramolecular electronic interactions presented between the attached imidazole derivatives groups and the nanotubes. Copyright (C) 2008 John Wiley & Sons, Ltd.

Application of 152628-02-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 152628-02-9.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4. In an article, author is Padalkar, Vikas S.,once mentioned of 152628-02-9, HPLC of Formula: C19H20N4.

A Combined Experimental and DFT-TDDFT Study of the Excited-State Intramolecular Proton Transfer (ESIPT) of 2-(2′-Hydroxyphenyl) Imidazole Derivatives

We report a combined experimental and computational study of the effect of electron donor and acceptor groups on the excited state intramolecular proton transfer of 2-(2′-hydroxyphenyl) imidazole derivatives in solvents of different polarities. The changes in fluorescence properties, electronic transitions and energy levels are analyzed and discussed. The study was complemented using the Density Functional Theory (DFT)-Time Dependent DFT [B3LYP/6-31G(d)] computations. The calculated absorption and emission spectra of the imidazole derivatives are in good agreement with the experiments, thus allowing an assignment of the UV-vis spectra.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 152628-02-9, you can contact me at any time and look forward to more communication. HPLC of Formula: C19H20N4.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4. In an article, author is BELAVIN, IY,once mentioned of 152628-02-9, COA of Formula: C19H20N4.

TRIMETHYLCHLOROSILANE-CATALYZED ATTACHMENT OF AZOLE DERIVATIVES TO 1-VINYLPYRROLIDONE-2 AND PHARMACOLOGICAL ACTIVITY OF RESULTANTS

The products of addition of pyrazole and imidazole derivatives with a free N-H bond to N-vinyl-2-pyrrolidone show anticonvulsive activity that has no relation to the effects of these substances on benzodiazepine receptors.

Interested yet? Keep reading other articles of 152628-02-9, you can contact me at any time and look forward to more communication. COA of Formula: C19H20N4.

Synthetic Route of 152628-02-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is Tian, Yuan, introduce new discover of the category.

Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-free conditions. A series of imidazole scaffolds were produced in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

Synthetic Route of 152628-02-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 152628-02-9.

Reference of 152628-02-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is Song, Zhegang, introduce new discover of the category.

Synthesis of Imidazole-Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications

Research on aggregation-induced emission (AIE) has become increasingly popular recently and various AIE luminogens (AIEgens) have been developed based on tetraphenylethene, hexaphenylsilole, distyrylanthracene, tetraphenylpyrazine, etc. However, facile tuning of the AIEgen emissions in a wide range remains challenging. Herein, a novel series of AIEgens is reported, based on imidazole-cored molecular rotors, with facile synthesis and emission colors covering the whole visible spectrum. Moreover, these imidazole derivatives exhibit biological functions unique among the AIEgens, including mitochondria-specific imaging and antifungal activity. Benefiting from the easy preparation and the tunable emission, the imidazole derivatives are expected to not only diversify the family of AIEgens but also enrich their biological applications.

Reference of 152628-02-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 152628-02-9 is helpful to your research.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4. In an article, author is UNANGST, PC,once mentioned of 152628-02-9, Quality Control of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.

OXAZOLE, THIAZOLE, AND IMIDAZOLE DERIVATIVES OF 2,6-DI-TERT-BUTYLPHENOL AS DUAL 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS

Benzylidene di-tert-butylphenols containing oxazole, thiazole, and imidazole substituents are dual inhibitors of 5-lipoxygenase and cyclooxygenase with IC50 values < 5 muM. The oxazole and thiazole analogs exhibit oral antiinflammatory activity. Interested yet? Keep reading other articles of 152628-02-9, you can contact me at any time and look forward to more communication. Quality Control of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole.