Application of 14840-18-7, These common heterocyclic compound, 14840-18-7, name is 3-(1H-Benzo[d]imidazol-1-yl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Oxalylchloride (2), (0.48 g, 3.52 mmol) was added to 2-benzimidazolepropionic acid (1), (0.5 g, 2.62 mmol) in a flask immersed in an ice bath, followed by the addition of few drops of DMF and 15 mL of DCM. The resulting reaction mixture was refluxed under magnetic stirring for 1 h. Then the solvent and the excess oxalyl chloride were removed by evaporation and the crude acyl derivative 3 was used immediately without further purification.
The synthetic route of 14840-18-7 has been constantly updated, and we look forward to future research findings.