Category: 14813-85-5

Application of 14813-85-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14813-85-5, name is 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Starting materials 16-18 (1 mmol) and K2CO3 (2 mmol) were suspended in DMF (1.8 mL) and stirred at 25 C for 30 min. 11 and 12, respectively (1.5 mmol) were added after 30 min and the solution was stirred at room temperature overnight. To the mixture was added ethyl acetate (5 mL) and water (5 mL).The aqueous layer was extracted several times with ethyl acetate (10 mL) and the combined organic layers were washed with brine, dried over MgSO4 and evaporated to dryness.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Neudorfer, Catharina; Seddik, Amir; Shanab, Karem; Jurik, Andreas; Rami-Mark, Christina; Holzer, Wolfgang; Ecker, Gerhard; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut; Molecules; vol. 20; 1; (2015); p. 1712 – 1730;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14813-85-5, name is 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C13H10N2O

a.) 21.0 g (100 mmol) 3-phenyl-1H-benzimidazol-2-one and 24.2 g (110 mmol) 4-bromo-2- fluoro-1-nitro-benzene, 27.6 g (200 mmol) potassium carbonate in DMF is stirred at 100 C for 20 h. The reaction mixture is poured in water and the water phase is extracted with (0803) dichloromethane. The organic phase is dried with magnesium sulfate and the solvent is removed in vacuum. Yield 23 g (56 %) 1H NMR (400 MHz, CDCl3): ^ = 8.11 (d, 1H), 7.92 (d, 1H), 7,79 (dd, 1H), 7.55.7.61 (m, 4H), 7.44-7.48 (m, 1H), 7.15-7.21 (m, 3H), 7.00-7.05 (m, 1H).

According to the analysis of related databases, 14813-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (320 pag.)WO2017/56053; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14813-85-5, name is 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C13H10N2O

a.) 15.72 g (74.8 mmol) of 3-phenyl-1 H-benzimidazol-2-one, 6.94 g (34.0 mmol) of 1 ,3-difluoro- 4,6-dinitrobenzene and 28.87 g (136 mmol) of K3P04 were mixed together in N M P (200 mL) at 0C for 2h. The mixture was then stirred 2h at room temperature and precipitated in water fil- trated to yield 19.44 g of 2-1 as a yellow powder [Purity = 85%(H PLC)] which was used directly as it is for the next step. (0778) Mass [M+1 ] = 584.2

According to the analysis of related databases, 14813-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; FLORES, Jean-Charles; NAGASHIMA, Hideaki; (236 pag.)WO2017/93958; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 14813-85-5,Some common heterocyclic compound, 14813-85-5, name is 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C13H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-phenyl-1,3-dihydro-benzimidazole-2-one, and 52g (250 mmol), in the first and K2CO3 of 38g (275 mmol), is introduced into the DMF of 100ml. After 1 hour at room temperature, it is added dropwise a solution of 2-bromobenzyl bromide 62g in DMF in 500 ml (250 mmol). The reaction mixture was then stirred for 25 hours at room temperature. After this time, the reaction mixture was poured onto ice, and extracted three times with dichloromethane. The combined organic phases are dried over Na2SO4, and evaporated. The residue was extracted with hot toluene, recrystallized from toluene / n-heptane. The yield is 65g (70%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; STOESSEL, PHILIPP; PARHAM, AMIR HOSSAIN; PFLUMM, CHRISTOF; JATSCH, ANJA; EBERLE, THOMAS; KROEBER, JONAS VALENTIN; (86 pag.)JP2016/500675; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem