Category: 14741-71-0

Application of 14741-71-0,Some common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: 4-Amino-3-(1H-benzimidazol-2-yl)-5-(4-ethylpiperazin-1-yl)quinolin-2(1H)-one t-BuLi (3.1 equivalents) was added to ethyl 2-benzimidazol-2-ylacetate (1.0 equivalent) and 6-amino-2-(4-ethylpiperazinyl) benzenecarbonitrile (1.0 equivalent) in THF at 0 C. The reaction was stirred overnight. The resulting mixture was quenched with NH4Cl (aqueous saturated) and extracted with EtOAc. The combined organic layers were washed with H2O and brine, dried over Na2SO4, filtered, and concentrated in vacuo to yield a brown solid. The crude material was triturated with CH2Cl2 and MeOH to provide a tan solid. LC/MS m/z 389.1 (MH+), Rt 1.80 minutes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, its application will become more common.

Application of 14741-71-0,Some common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: LHMDS (1.65 mL, 1 M in THF, 1.65 mmol, 5.0 equiv) was added dropwise to a solution of ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (67.6 mg, 0.33 mmol, 1.0 equiv) and 1-(4-methoxybenzy-l)-1H-thieno[2,3-d][1,3]oxazine-2,4-dione (0.33 mmol, 1.0 equiv) in anhydrous THF (15 mL) at -78 C. The resulting solution was slowly warmed to room temperature and then stirred overnight at 80 C. After the reaction completed, quenched with a small amount of NH4Cl (aq, satd). And then concentrated in vacuo, the resulting crude material was purified by column chromatography (petroleum ether/ethyl acetate/acetic acid = 500:100:20, v/v/v) on silica gel to afford the product as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, its application will become more common.

14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C11H12N2O2

General procedure: To the dry solid of compound 3 (2.04 g, 0.01 mol) ammonium acetate (0.50 g) eithercyclophentanone (0.78 g, 0.01 mol) or cyclohexanone (0.92 g, 0.01 mol) were added. Thereaction mixture was heated in an oil bath at 120 oC for 1 h then left to cool. The product wastriturated with ethanol and the formed solid product was collected by filtration.Ethyl 2-(1H-benzo[d]imidazol-2-yl)-2-cyclopentylideneacetate (15a). Pale yellow crystals fromethanol; yield: 2.53 g (83%); m.p. 155 oC. IR, : 3459-3322 (NH), 3053 (CH aromatic), 2929,2863 (CH3, CH2), 1686 (CO), 1636 (C=N), 1630 (C=C). 1H-NMR: : 1.13 (t, 3H, J = 6.93 Hz,CH3), 1.18-1.24 (m, 4H, 2CH2), 2.19-2.21 (m, 4H, 2CH2), 4.22 (q, 2H, J = 6.93 Hz, CH2), 7.27-7.38 (m, 4H, C6H4), 8.32 (s, 1H, NH, D2O exchangeable). 13C NMR (DMSO): 16.2 (ester CH3),1.89-2.13 (2m 4CH2), 52.6 (ester CH2), 86.4, 90.6 (C=C), 120.3, 121.2, 123.2, 125.6, 128.6(C6H4), 164.8 (CO), 173.2 (C=N); Anal. calcd for C16H18N2O2: C, 71.09; H, 6.71; N, 10.36%.Found: C, 70.93; H, 6.93; N, 10.47%. MS: m/z: (%) 270 (M+, 36%).

The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 14741-71-0,Some common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of compound 3 (2.04 g, 0.01 mol) in dimethylformamide (30 mL) either aniline(0.93 g, 0.01 mol) or 4-methylaniline (1.08 g, 0.01 mol) was added. The reaction mixture, ineach case, was heated under reflux for 4 h then poured onto ice/water mixture containing fewdrops of hydrochloric acid and the formed solid product was collected by filtration. 2-(1H-Benzo[d]imidazol-2-yl)-N-phenylacetamide (5a). Light brown crystals from ethanol;yield: 2.08 g (80%); m.p. 220-222 oC. IR, : 3472-3324 (2NH), 3050 (CH aromatic), 1680(C=O), 1648 (C=N), 1629 (C=C). 1H-NMR, : 4.93 (s, 2H, CH2), 7.25-7.41 (m, 9H, C6H5,C6H4), 8.26, 8.32 (2s, 2H, 2NH, D2O exchangeable). 13C NMR (DMSO): 54.8 (CH2), 119.2,120.8, 122.8, 123.6, 124.3, 125.2, 126.1, 127.3, 128.3, 129.2, (C6H5, C6H4), 164.8 (CO), 172.4(C=N); Anal. calcd for C15H13N3O: C, 71.70; H, 5.21; N, 16.72%. Found: C, 71.83; H, 5.08; N,16.82%. MS: m/z: (%) 251 (M+, 24%).

The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate

Ethyl 2-BENZIMIDAZOL-2-YLACETATE (1.1 equivalents) and 2-amino- 5-(4-METHYLPIPERAZINYL) BENZENECARBONITRILE (1.0 equivalent) were dissolved in 1, 2-dichloroethane, and then SNCL4 (11 equivalents) was added. The mixture was heated at reflux overnight. Upon cooling, the mixture was concentrated in vacuo. NAOH (3 M) was added to the solid, and the mixture heated at 80 C for 0.5 hours. The solid was filtered and washed sequentially with H2O, CH2CI2, and acetone. LC/MS indicated that the product was present in the acetone layer and the solid. These fractions were combined and purified by silica gel chromatography (5-10% MeOH in CH2CI2 with 1 % ET) to give the desired product. LC/MS M/Z 375.4 (MH+), Rt 1.65 minutes.

The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 14741-71-0, A common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: LHMDS (1.65 mL, 1 M in THF, 1.65 mmol, 5.0 equiv) was added dropwise to a solution of ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (67.6 mg, 0.33 mmol, 1.0 equiv) and 1-(4-methoxybenzy-l)-1H-thieno[2,3-d][1,3]oxazine-2,4-dione (0.33 mmol, 1.0 equiv) in anhydrous THF (15 mL) at -78 C. The resulting solution was slowly warmed to room temperature and then stirred overnight at 80 C. After the reaction completed, quenched with a small amount of NH4Cl (aq, satd). And then concentrated in vacuo, the resulting crude material was purified by column chromatography (petroleum ether/ethyl acetate/acetic acid = 500:100:20, v/v/v) on silica gel to afford the product as a white solid.

The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Song, Pinrao; Peng, Peng; Han, Mengmeng; Cao, Xianchao; Ma, Xiaodong; Liu, Tao; Zhou, Yubo; Hu, Yongzhou; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4882 – 4892;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14741-71-0, category: imidazoles-derivatives

General procedure: To a solution of compound 3 (2.04 g, 0.01 mol) in ethanol (30 mL) containing piperidine (0.50 mL) either benzaldehyde (1.06 g, 0.01 mol) or 4-methoxy benzaldehyde (1.31 g, 0.01 mol) or 4-chlorobenzaldehyde (1.34 g, 0.01 mol) was added. The reaction mixture, in each case, was heated under reflux for 3 h then poured onto ice/water mixture containing few drops of hydrochloric acid and the formed solid product was collected by filtration. Ethyl 2-(1H-benzo[d]imidazol-2-yl)-3-phenylacrylate (7a). Gray crystals from ethanol; yield:2.45 g (77%); m.p. > 300 oC. IR, : 3478-3329 (NH), 3057 (CH aromatic), 2962, 2873 (CH3,CH2), 1688 (C=O), 1646 (C=N), 1630 (C=C). 1H-NMR: : 1.14 (t, 3H, J = 7.66 Hz, CH3), 4.21(q, 2H, J = 7.66 Hz, CH2), 6.24 (s, 1H, CH=C), 7.29-7.38 (m, 9H, C6H5, C6H4), 8.26 (s, 1H, NH,D2O exchangeable). 13C NMR (DMSO): 16.3 (ester CH3), 52.5 (ester CH2), 89.3, 90.2 (CH=C),120.6, 122.1, 123.2, 123.9, 124.1, 124.6, 125.8, 126.2, 127.8, 128.2, (C6H5, C6H4), 164.8 (CO),172.6 (C=N); Anal. calcd for C18H16N2O2: C, 73.95; H, 5.52; N, 9.58%. Found: C, 72.73; H,5.49; N, 9.37%. MS: m/z: (%) 292 (M+, 64%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 14741-71-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

Example 37: Synthesis of 3-Fluoro-l,7,llb-triaza-benzo[c]fluorene-6-carboxylic acid ethyl es [0321] To a solution of compound SMI (0.8 g, 5 mmol) and compound SM2 (1.02 g, 5 mmol) in ethanol (50 mL) was added piperidine (1.28 g, 15 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 16h. After cooling, the mixture was filtered and washed with ethanol, dried to get compound 7A as yellow solid (0.82 g, 79 yield). LCMS: m/z 309.9 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; HADDACH, Mustapha; WO2015/172123; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 14741-71-0, The chemical industry reduces the impact on the environment during synthesis 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, I believe this compound will play a more active role in future production and life.

[0295] To a suspension of SMI (25.9 g, 148 mmol) and SM2 (30 g, 147 mmol) in ethanol (400 mL) was added SM3 (33.5 g, 394 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 6 h. The mixture was then cooled to 20 C and the precipitate collected by filtration to give Ethyl 2-(4-methyl-[l,4]diazepan-l-yl)-l,7,l lb- triazabenzo[c]fluorene-6-carboxylic acid (40 g, 68 yield) as a pale yellow solid. LCMS

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HADDACH, Mustapha; WO2015/172123; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate

Example 45: Synthesis of 4-(4-Methyl-[l,4]diazepan-l-yl)-l,7,llb-triaza-benzo[c]fluorene- 6-carboxylic acid ethyl ester (Compound 8A) [0329] To a solution of SMI (176 mg, 1 mmol) and SM2 (204 mg, 1 mmol) in 2- Methoxyethanol (10 mL) was added N-Methylhomopiperazine (342 mg, 3 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 16h. The crude product was purification by gel silica column (DCM/MeOH=50: l) to get compound 8A as brown oil (320 mg, 79 yield). LCMS: m/z 404 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; HADDACH, Mustapha; WO2015/172123; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem