Adding a certain compound to certain chemical reactions, such as: 147359-76-0, name is Flibanserin Hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 147359-76-0, Quality Control of Flibanserin Hydrochloride
44 L of ethanol and 300 kg of water were added to the autoclave, followed by the addition of 22 kg of compound V (fluoropancaline hydrochloride)After heating, the temperature was 80 C. After the solid was completely dissolved, the anhydrous potassium carbonate solution (11. 7 kg of anhydrous potassium carbonate was dissolved in 96 kg of water) was added dropwise and incubated at 80 C for 2 hours.Cooled to room temperature, stirred for 3 hours, filtered, filtered at 50 C for 5 hours,Finished product 18. 61 kg, yield 92.5%, HPLC purity 99. 95%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Flibanserin Hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Shandong Cheng Chuang Pharmaceutical Development Co., Ltd.; Guo Zhenxing; Lv Zhitao; Yao Songzhi; Li Shujin; (12 pag.)CN106749038; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem