Category: 145040-37-5

A reactive oxygen species Ca²⁺ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression was written by Li, Xiang;Deng, Dongjing;Cataltepe, Gizem;Roman, Angela;Buckley, Christopher R.;Cassano Monte-Bello, Carolina;Skyricz, Aleksandra;Caldana, Camila;Haydon, Michael J.. And the article was included in New Phytologist in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

Sugars are essential metabolites for energy and anabolism that can also act as signals to regulate plant physiol. and development. Exptl. tools to disrupt major sugar signalling pathways are limited. We performed a chem. screen for modifiers of activation of circadian gene expression by sugars to discover pharmacol. tools to investigate and manipulate plant sugar signalling. Using a library of com. available bioactive compounds, we identified 75 confident hits that modified the response of a circadian luciferase reporter to sucrose in dark-adapted Arabidopsis thaliana seedlings. We validated the transcriptional effect on a subset of the hits and measured their effects on a range of sugar-dependent phenotypes for 13 of these chems. Chems. were identified that appear to influence known and unknown sugar signalling pathways. Pentamidine isethionate was identified as a modifier of a sugar-activated Ca2+ signal that acts as a calmodulin inhibitor downstream of superoxide in a metabolic signalling pathway affecting circadian rhythms, primary metabolism and plant growth. Our data provide a resource of new exptl. tools to manipulate plant sugar signalling and identify novel components of these pathways. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number was written by Bennett-Lenane, Harriet;Koehl, Niklas J.;O’Dwyer, Patrick J.;Box, Karl J.;O’Shea, Joseph P.;Griffin, Brendan T.. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Computational approaches are increasingly utilized in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study investigated if in silico predictions of drug solubility gain i.e. solubility ratios (SR), after dispersion of a SEDDS in biorelevant media could be predicted from drug properties. Apparent solubility upon dispersion of two SEDDS in FaSSIF was measured for 30 structurally diverse poorly water soluble drugs. Increased drug solubility upon SEDDS dispersion was observed in all cases, with higher SRs observed for cationic and neutral vs. anionic drugs at pH 6.5. Mol. descriptors and solid-state properties were used as inputs during partial least squares (PLS) modeling resulting in predictive models for SRMC (r2 = 0.81) and SRLC (r2 = 0.77). Multiple linear regression (MLR) facilitated generation of simplified SR equations with high predictivity (SRMC r2 = 0.74; SRLC r2 = 0.69), requiring only three drug properties; partition coefficient at pH 6.5 (logD6.5), m.p. (Tm) and aromatic bonds as fraction of total bonds (F-AromB). Through using the equations to inform developability classification system (DCS) classes for drugs that have already been licensed as lipid-based formulations, merits for development with SEDDS was predicted for 2/3 drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation & evaluation of spherical crystal agglomerates of Candesartan Cilexetil was written by Chaubisa, Prachi D.;Shah, S. K.;Chaudhary, Bhumika. And the article was included in World Journal of Pharmaceutical Research in 2018.Product Details of 145040-37-5 This article mentions the following:

A quasi-emulsion solvent diffusion method was adopted for preparation of spherical agglomerates of Candesartan Celexetil using Acetone as a good solvent and water as a poor solvent. Dichloromethane was added to the solution of Candesartan Cilexetil as Bridging liquid Preliminary trials were taken to identify significant factors affecting formation of spherical agglomerates. A 32 full factorial design was employed to study the effect of following independent variables at the three different levels on the characteristics of the product obtained. They are amount of PVA and amount of PEG 4000. Exptl. trials were performed at all possible 9 combinations in and the resultant product obtained was evaluated for parameters like saturation solubility, Hausner ratio, Carr’s index and amount of the drug dissolved in 180 min. Based on factorial design anal., it found that the selected factors having significant effect on % drug release. Tablets prepared by using optimized spherical crystal agglomerates of F4 batch and evaluation done. All phys. parameters found within acceptable range. Further the dissolution of tablets in 180 min found more than 90% which was also compared with marketed formulation. The release kinetic model found most satisfactory with Higuchi Model. Stability of spherical crystal agglomerates Tablets of Candesartan Cilexetil found stable after 1 mo. Hence, spherical crystal agglomerates of Candesartan Cilexetil successfully prepared by quasi-emulsion solvent diffusion method and solubility improved. Further based on the results. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem