Category: 14486-52-3

Synthetic Route of 14486-52-3, The chemical industry reduces the impact on the environment during synthesis 14486-52-3, name is 1-Methyl-2-(methylthio)imidazole, I believe this compound will play a more active role in future production and life.

General procedure: 1-Methylimidazole (0.49 g, 6.05 mmol) was added to a stirred solution of Key Intermediate-1 (2.3 g, 4.03 mmol) in acetonitrile (25 mL) at RT. The reaction mixture was heated to 90 C for 16 h and concentrated under reduced pressure. The crude material was triturated with diethyl ether (2 x 10 mL) to afford a brown solid (2.4g) which was used in the next steps without further purification. M/z 616.38 (M)+ TFA: H2O (9:1, 20 mL) was added to the brown solid (2.4 g) at RT. The reaction mixture was stirred for 3 h and concentrated under reduced pressure. The resulting crude product was triturated with diethyl ether (2 x 5 mL) and dried under high vacuum. The crude product was purified by preparative HPLC affording the title product as off-white solid (515 mg, 30% over 2 steps).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-2-(methylthio)imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Antabio SAS; DAVIES, David; LEIRIS, Simon; (56 pag.)EP3572411; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14486-52-3, name is 1-Methyl-2-(methylthio)imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 14486-52-3

A. 2-Methylthio-3-methyl-1-(2-mercaptoethyl)imidazolium trifluoromethanesulfonate STR193 Trifluoromethanesulfonic acid (1.38 mL, 0.015 mol) was added dropwise to 2-methylthio-1-methylimidazole1 (4.0 g), 0.03 mol) at 0 C. under N2. Ethylene sulfide (0.9 mL, 0.015 mol) was then added and the mixture was heated at 55 C. under N2 for 24 h. The reaction mixture was triturated with ether (3x) and the residue was taken up in acetone, filtered and evaporated. This gave the product (4.2 g, 82%) as a semicrystalline solid which was used as such without further purification. ir(film) numax: 2550 (w, sh) cm-1; ‘Hnmr (d6 -acetone) delta: 7.97 (s, 2H), 4.66 (t, J=7 Hz, 2H, methylene), 4.17 (s, 3H, N-Me), 3.20 (d of t, J=7 Hz, J’=9 Hz, 2H, methylene), 2.72 (s, 3H, S-Me), 2.20 (t, J =9 Hz, 1H, –SH).

The synthetic route of 14486-52-3 has been constantly updated, and we look forward to future research findings.