Category: 141556-45-8

《Two-Coordinate Copper(I)/NHC Complexes: Dual Emission Properties and Ultralong Room-Temperature Phosphorescence》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Li, Jiayi; Wang, Liding; Zhao, Zifeng; Li, Xiaoyue; Yu, Xiao; Huo, Peihao; Jin, Qionghua; Liu, Zhiwei; Bian, Zuqiang; Huang, Chunhui. Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride The article mentions the following:

As a kind of photoluminescent material, CuI complexes have many advantages such as adjustable emission, variable structures, and low cost, attracting attention in many fields. In this work, two novel two-coordinate CuI-N-heterocyclic carbene complexes were synthesized, and they exhibit unique dual emission properties, fluorescence and phosphorescence. The crystal structure, packing mode, and photophys. properties under different conditions were systematically studied, proving the emissive mechanism to be the locally excited state of the carbazole group. Based on this mechanism, ultralong room-temperature phosphorescence (RTP) with a lifetime of 140 ms is achieved by selective deuteration of the carbazole group. These results deepen the understanding of the luminescence mechanism and design strategy for two-coordinate CuI complexes, and prove their potential in applications as ultralong RTP materials. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《A quantitative empirical directing group scale for selectivity in iridium-catalysed hydrogen isotope exchange reactions》 was published in Catalysis Science & Technology in 2020. These research results belong to Timofeeva, Daria S.; Lindsay, David M.; Kerr, William J.; Nelson, David J.. Synthetic Route of C21H25ClN2 The article mentions the following:

A palette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quant. ranked based on the results of intermol. hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructed from these data reveal a wide range of reactivity covering four orders of magnitude. Intramol. competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within mols. with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalyzed C-H activation reactions. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Synthetic Route of C21H25ClN2)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Synthetic Route of C21H25ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chlorideIn 2022 ,《Ruthenium complexes with chelating carboxylate-NHC ligands as efficient catalysts for C-H arylation in water》 was published in Mendeleev Communications. The article was written by Shepelenko, Konstantin E.; Nikolaeva, Ksenia A.; Shevchenko, Maxim A.; Tkachenko, Yurii N.; Minyaev, Mikhail E.; Chernyshev, Victor M.. The article contains the following contents:

Ruthenium(II) complexes [(p-cymene)RuCl(3-R-Im-1-CH2CO2)] (1a-c, H2Im = 2-imidazolylidene; R = Me, Mes, Dipp), [(p-cymene)RuCl(3-R1-Im-1-CH2CONR2)] (2a-d; R1 = Me, Mes, Dipp; R2 = Dipp, tBu, Mes) with chelating N-heterocyclic carbene (NHC) ligands functionalized with carboxy and carboxamidato pendant groups, were prepared and examined as catalysts for ortho-C-H arylation of Ph groups in 2-phenylpyridine and 1-phenylpyrazole with aryl chlorides in water affording substituted 2-(m-terphenylyl)pyridines and 1-(m-terphenylyl)pyrazoles. Complexes with NHC-ligands containing a hemilabile coordinating N-carboxylatomethyl group enable fast and selective ortho-CH-diarylation in the absence of carboxylate-assisting additives. In the experimental materials used by the author, we found 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Enantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups》 was written by Chen, Hao; Wang, Yin-Xia; Luan, Yu-Xin; Ye, Mengchun. SDS of cas: 141556-45-8 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved. Ni-Al bimetallic catalysis enabled by a bulky BINOL-derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40-98% yield and 93-99% ee. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8SDS of cas: 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.SDS of cas: 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mandal, Tanmoy; Yadav, Sudha; Choudhury, Joyanta published their research in Journal of Organometallic Chemistry in 2021. The article was titled 《Steric effect of NHC ligands in Pd(II)-NHC-catalyzed non-directed C-H acetoxylation of simple arenes》.Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride The article contains the following contents:

Herein, a series of well-defined discrete [Pd(NHCRR1)(py)I2] complexes I [R = Me, Cy, n-Bu, Mes; R1 = Me, Cy, n-Bu, Mes, t-Bu, Ph; RR1 = Me, Cy, n-Bu, Mes] with systematically varied degree of spatial congestion at the Pd center, exerted through the R and R1 substituents on the NHC ligand, were explored in controlling the activity as well as the site-selectivity of non-directed acetoxylation of representative monosubstituted and disubstituted simple arenes (such as toluene, iodobenzene and bromobenzene, naphthalene and 1,2-dichlorobenzene). The resulting best yields were found to be 75% for toluene and 65% for bromobenzene with [Pd(NHCPhMe)(py)I2], 75% for iodobenzene and 79% for naphthalene with [Pd(NHCMeMe)(py)I2], and 41% for 1,2-dichlorobenzene with [Pd(NHCCyCy)(py)I2]. Most importantly, with increasing the bulkiness of the NHC ligand in the complexes, the selectivity of the distal C-acetoxylated products in comparison to the proximal ones, was enhanced to a great extent in all cases. Considering the vast library of NHC ligands, this study underscores the future opportunity to develop more strategies to improve the activity and the crucial site-selectivity of C-H functionalization reactions in simple as well as complex organic mols. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Zhi-Mao; Xu, Yu-Ting; Shao, Li-Xiong published an article in 2021. The article was titled 《Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides》, and you may find the article in Journal of Organometallic Chemistry.Category: imidazoles-derivatives The information in the text is summarized as follows:

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand was obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes was an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enriched the chem. of NHCs and gave an alternative catalyst for the coupling of challenging while cost-low aryl chlorides. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Category: imidazoles-derivatives)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 141556-45-8In 2022 ,《Antileishmanial activity and insights into the mechanisms of action of symmetric Au(I) benzyl and aryl-N-heterocyclic carbenes》 was published in Journal of Inorganic Biochemistry. The article was written by Rosa, Leticia B.; Galuppo, Carolina; Lima, Rochanna L. A.; Fontes, Josielle V.; Siqueira, Fabio S.; Judice, Wagner A. S.; Abbehausen, Camilla; Miguel, Danilo C.. The article contains the following contents:

Leishmania amazonensis and L. braziliensis are the main etiol. agents of the American Tegumentary Leishmaniasis (ATL). Taking into account the limited effectiveness and high toxicity of the current drug arsenal to treat ATL, novel options are urgently needed. Inspired by the fact that gold-based compounds are promising candidates for antileishmanial drugs, we studied the biol. action of a systematic series of six (1)-(6) sym. Au(I) benzyl and aryl-N-heterocyclic carbenes. All compounds were active at low micromolar concentrations with 50% effective concentrations ranging from 1.57 to 8.30 μM against Leishmania promastigotes. The mesityl derivative (3) proved to be the best candidate from this series, with a selectivity index ∼13 against both species. The results suggest an effect of the steric and electronic parameters of the N-substituent in the activity. Intracellular infections were drastically reduced after 24h of (2)-(5) incubation in terms of infection rate and amastigote burden. Further investigations showed that our compounds induced significant parasites′ morphol. alterations and membrane permeability. Also, (3) and (6) were able to reduce the residual activity of three Leishmania recombinant cysteine proteases, known as possible targets for Au(I) complexes. Our promising results open the possibility of exploring gold complexes as leishmanicidal mols. to be further screened in in vivo models of infection.1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Related Products of 141556-45-8) was used in this study.

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Related Products of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《NHC-Catalyzed Oxidative Annulation of α,β-unsaturated Aldehydes with Benzyl Ketones: Direct Access to 4,5,6-Trisubstituted Dihydropyranones》 was written by Wang, Zhan-Yong; Liu, Qingling; Wang, Kai-Kai; Liu, Menghan; Han, Yafei; Sun, Aili; Ma, Xueji. Application of 141556-45-8This research focused ontrisubstituted dihydropyranone preparation green chem; unsaturated aldehyde benzyl ketone oxidative cyclization NHC catalyst. The article conveys some information:

A novel and efficient access to polysubstituted dihydropyranones I (R = Ph, 4-MeOC6H4, 2-furyl, n-Pr, etc.; Ar = Ph, 4-MeC6H4, 4-ClC6H4; Ar1 = Ph, 2-naphthyl, 4-NCC6H4, etc.) was developed by N-heterocyclic carbene catalyzed annulation reaction of α,β-unsaturated aldehydes and benzyl ketones under oxidative conditions. Various α,β-unsaturated aldehydes with long-chain aliphatic and aromatic substitution groups were compatible in this transformation, giving the corresponding products in good to excellent yields under mild conditions. This strategy features simple and readily available materials and mild reaction conditions and provides a green and practical method for the rapid synthesis of functionalized dihydropyranones. In the experiment, the researchers used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Development of a multistep, electrochemical flow platform for automated catalyst screening》 was written by Schotten, Christiane; Manson, Jamie; Chamberlain, Thomas W.; Bourne, Richard A.; Nguyen, Bao N.; Kapur, Nik; Willans, Charlotte E.. COA of Formula: C21H25ClN2This research focused ontriazole electrochem catalyst copper electrode. The article conveys some information:

The development of an integrated multistep flow platform that incorporates high-throughput electrochem. synthesis of metal catalysts and catalysis screening is described. Ligand libraries can be screened through the implementation of an autosampler, and online HPLC anal. facilitates continuous monitoring of the reaction. The equipment is controlled via a computer which enables the process to be automated, with the platform running ligand/catalysis screens autonomously. The platform has been validated using a ubiquitous Cu-NHC catalyzed click reaction, with conditions chosen so that the reaction does not run at full conversion, which allows the effect of different ligand precursors to be observed An efficient cleaning step is crucial to the reproducibility of reactions, and alternating polarity ensures the long-term stability of the electrochem. reactor. This technol. will enable the profiling of catalysts in continuous systems and accelerate the process of developing more sustainable base-metal catalysts in manufacturing processes. The experimental process involved the reaction of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8COA of Formula: C21H25ClN2)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.COA of Formula: C21H25ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Kyan, Ryuji; Sato, Kohei; Mase, Nobuyuki; Narumi, Tetsuo. Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride The article mentions the following:

Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer. The results came from multiple reactions, including the reaction of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application In Synthesis of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem