Category: 141556-45-8

Chesnokov, V. V.; Shevchenko, M. A.; Soliev, S. B.; Tafeenko, V. A.; Chernyshev, V. M. published their research in Russian Chemical Bulletin in 2021. The article was titled 《Complexes LNi(Cp)X with alkylamino-substituted N-heterocyclic carbene ligands (L) and their catalytic activity in the Suzuki-Miyaura reaction》.SDS of cas: 141556-45-8 The article contains the following contents:

New nickel(II) complexes of the general formula LNi(Cp)X (L is an N-heterocyclic carbene (NHC) ligand of the 1,2,4-triazole or imidazole series; Cp is the cyclopentadienyl anion; X = Cl, I) are reported. In these complexes, the NHC ligands (L) contain an alkylamino group at the 3 or 4 position of the heterocycle. The synthesized complexes and structurally similar complexes without an alkylamino group were tested for catalytic activity in the Suzuki-Miyaura reaction. The introduction of an alkylamino group into the NHC ligand leads to the enhancement of the catalytic activity of complexes with N,N’-diaryl-substituted NHC ligands of the imidazole series and a decrease in the activity of the complexes with N,N’-dialkyl-substituted NHC ligands of the 1,2,4-triazole series. In the experimental materials used by the author, we found 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8SDS of cas: 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.SDS of cas: 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Wei-Ze; Wang, Zhong-Xia published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols》.Application of 141556-45-8 The article contains the following contents:

α-Alkylation of methyldiarylphosphine oxides with (hetero)arylmethyl alcs. was performed under nickel catalysis. Various arylmethyl and heteroarylmethyl alcs. can be used in this transformation. A series of methyldiarylphosphine oxides were alkylated with 30-90% yields. Functional groups on the aromatic rings of methyldiarylphosphine oxides or arylmethyl alcs. including OMe, NMe2, SMe, CF3, Cl, and F groups can be tolerated. The conditions are also suitable for the α-alkylation reaction of dialkyl methylphosphonates. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kumar, D. Sharath; Pallavi, H. S.; Pullela, Phani Kumar published their research in Asian Journal of Chemistry in 2021. The article was titled 《Detection of non-nitro compounds by amplified fluorescence polymer (AFP): an opportunity for breath-based disease diagnosis》.Synthetic Route of C21H25ClN2 The article contains the following contents:

Amplified fluorescence polymers (AFP) are a set of unique polymers known for their ability to detect trace nitro explosives. The prior knowledge in the AFP field indicates that the functional group variation on the polymer backbone is responsible for the selectivity of an analyte. The mechanism of analyte detection is believed that only compounds with nitro functional groups are detected by AFP. Usually, AFP functional groups varied to detect nitro compounds and the non-nitro compound detection and the mechanism of the AFP were not completely understood. In this work, the AFP polymer was kept constant and studied with 136 analytes with different functional groups for analyzing few non-nitro compounds Among the 136 compounds analyzed, about fourteen have been detected by AFP. It was observed that most of the fourteen compounds were non-nitro compounds The mechanism proposed originally for nitro compounds and associated hypothesises the existence of a parking space on the polymer backbone. Present study suggested that the possibility of only nitro compounds interacting with AFP due to the three-dimensional shape of the analyte as the detrimental factor. The discovery of non-nitro compound detection by AFP opens up the use of AFP for gas-phase disease volatile organic compound detection. Future studies of functional group variation on the AFP backbone in relation to the analyte detection could provide insights into the relation of analyte detection by AFP and the parameters to optimize for obtaining the selectivity and specificity. In the experiment, the researchers used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Synthetic Route of C21H25ClN2)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Synthetic Route of C21H25ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis, catalytic activity and medium fluorous recycle of fluorous analogues of PEPPSI catalysts》 was written by Simunek, Ondrej; Rybackova, Marketa; Svoboda, Martin; Kvicala, Jaroslav. Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride And the article was included in Journal of Fluorine Chemistry in 2020. The article conveys some information:

PEPPSI complexes are air and moisture stable Pd catalysts, which can be used conveniently in many coupling reactions. With the aim to obtain Pd catalysts recyclable by fluorous separation methods, we modified the structure of com. PEPPSI complexes by per- or polyfluoroalkylation in various positions. The modifications included the use of a linear polyfluoroalkyl group instead of one aryl group on the NHC ligand, perfluoroalkylation of pyridine ligand, and substitution of chloride ligands on Pd for perfluoroalkanoates or perfluoropolyoxaalkanoates. Comparison of catalytic activity of com. catalysts with the modified ones in Suzuki-Miyaura cross-coupling reactions showed that the fluorous modifications mostly resulted in the increase of catalytic activity. Moreover, polyfluoroalkylation enabled efficient medium fluorous recycle of the modified catalysts using a two phase aqueous DMF/HFE 7500 ether system. In the part of experimental materials, we found many familiar compounds, such as 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Ghanbari, Hamed; Robertson, Katherine N.; Clyburne, Jason A. C.; Soleimani, Ebrahim published an article in Canadian Journal of Chemistry. The title of the article was 《Betaine formation from the reactions of N-heterocyclic carbenes with polarized alkenes》.SDS of cas: 141556-45-8 The author mentioned the following in the article:

N-Heterocyclic carbenes, 1,3-dimesityl-2-imidazolylidene (1a, IMes) or 1,3-bis(2,6-di-isopropylphenyl)imidazolidinylidene (1b, SIPr) react with the polarized alkenes ArCH:CX2 to form the crystalline betaines NHC-CHArCX2 (3a, 3b; Ar = 4-MeOC6H4, X2 = CONMeCSNMeCO; NHC = IMes, SIPr) and IMes-CHAr1C(CN)2 (5a; Ar1 = 2-MeOC6H4). Furthermore, a one-pot reaction between an aldehyde, malononitrile, and an imidazolium salt of an N-heterocyclic carbene has been developed for the efficient preparation of betaine 5a without isolation of the free carbene. Full characterization data, including X-ray crystal structures, is reported for the three synthesized betaines. The structures of the betaines 3a, 3b, and 5a shed new light on the initial products formed in the reactions between N-heterocyclic carbenes and compounds containing polarized double bonds. In addition to this study using 1,3-Dimesityl-1H-imidazol-3-ium chloride, there are many other studies that have used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8SDS of cas: 141556-45-8) was used in this study.

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.SDS of cas: 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity》 was written by Kankala, Shravankumar; Rama, Koteshwar Rao; Kesari, Chekrapani; Bjorkling, Fredrik; Nerella, Srinivas; Gundepaka, Prasad; Guguloth, Hanmanthu; Thota, Niranjan. Application of 141556-45-8 And the article was included in Synthetic Communications in 2020. The article conveys some information:

A series of fluorophenylpyrazole-picolinamide derivatives were synthesized in high yields using a cross-coupling reaction catalyzed by in-situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). The synthesized novel derivatives were evaluated for in-vitro anticancer activity against a panel of four human tumor cell lines, HeLa (cervical), A-549 (lung), MCF-7 (breast), and IMR-32 (neuroblastoma). Four compounds showed growth inhibition (low μM) comparable with the standard drug cisplatin, provided a preliminary structure-activity relationship for the series. The present procedure was operationally simple and worked with a wide range of substrates and may thus be useful in further compound optimization. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Copper-catalyzed boroacylation of allenes to access tetrasubstituted vinylboronates》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Shen, Bing-Xue; Min, Xiang-Ting; Hu, Yan-Cheng; Qian, Lei-Lei; Yang, Sa-Na; Wan, Boshun; Chen, Qing-An. Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride The article mentions the following:

A distinct copper-catalyzed boroacylation of allenes with acyl chlorides and bis(pinacolato)diboron is developed. For aromatic acyl chlorides, 1,2-boroacylation of allenes readily takes place, leading to the formation of tetrasubstituted vinylboronates with exclusive (E)-stereoselectivity. In comparison, the employment of alkyl acyl chlorides as electrophiles alters the selectivity to 2,3-boroacylated products. Addnl., the product can easily undergo Suzuki-Miyaura cross-coupling to afford tetrasubstituted alkene with complete retention of the configuration. The experimental process involved the reaction of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Miyamoto, Yukiko; Aggarwal, Shubhangi; Celaje, Jeff Joseph A.; Ihara, Sozaburo; Ang, Jonathan; Eremin, Dmitry B.; Land, Kirkwood M.; Wrischnik, Lisa A.; Zhang, Liangfang; Fokin, Valery V.; Eckmann, Lars published an article in 2021. The article was titled 《Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in Trichomonas vaginalis》, and you may find the article in Journal of Medicinal Chemistry.Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride The information in the text is summarized as follows:

Trichomonas vaginalis causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clin. problem. The gold(I) complex, auranofin, is active against T. vaginalis and other protozoa but has significant human toxicity. In a systematic structure-activity exploration, authors show here that diversification of gold(I) complexes, particularly as halides with simple C1-C3 trialkyl phosphines or as bistrialkyl phosphine complexes, can markedly improve potency against T. vaginalis and selectivity over human cells compared to that of the existing antirheumatic gold(I) drugs. All gold(I) complexes inhibited the two most abundant isoforms of the presumed target enzyme, thioredoxin reductase, but a subset of compounds were markedly more active against live T. vaginalis than the enzyme, suggesting that alternative targets exist. Furthermore, all tested gold(I) complexes acted independently of Mz and were able to overcome Mz resistance, making them candidates for the treatment of Mz-refractory trichomoniasis. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Name: 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Carbene-Catalyzed Formal [3+3] Cycloaddition Reaction for Access to Substituted 2-Phenylbenzothiazoles》 was written by Ni, Zhibin; Mou, Chengli; Zhu, Xun; Qi, Puying; Yang, Song; Chi, Yonggui Robin; Jin, Zhichao. Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A carbene-catalyzed oxidative cycloaddition reaction is developed for efficient access to multi-functionalized 2-phenylbenzothiazoles. A broad scope of heavily substituted arenes bearing 2-benzothiazole groups were prepared in good to excellent yields. The remote C(sp2)-H bond in the substituted arene products can be activated by Pd catalysts in regio-selective fashion with the direction of the 2-benzothiazole groups. In the experiment, the researchers used many compounds, for example, 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Liu, Yaxu; Scattolin, Thomas; Gobbo, Alberto; Belis, Marek; Van Hecke, Kristof; Nolan, Steven P.; Cazin, Catherine S. J. published an article in European Journal of Inorganic Chemistry. The title of the article was 《A Simple Synthetic Route to Well-Defined [Pd(NHC)Cl(1-tBu-indenyl)] Pre-catalysts for Cross-Coupling Reactions》.Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chloride The author mentioned the following in the article:

A simple synthetic access to [Pd(NHC)Cl(1-tBu-indenyl)] complexes bearing different saturated and unsaturated NHC ligands was reported. All complexes were obtained in excellent yields under mild conditions (60°C, 1 h) in the presence of the weak base K2CO3 in green acetone as the solvent. We view synthetic access as vital in delineating the precatalyst choice and have demonstrated here the facile access to these complexes was reported. The catalytic activity of the synthesized derivatives were investigated on three different cross-coupling reactions such as Suzuki-Miyaura, unconventional Suzuki-Miyaura reaction and Buchwald-Hartwig amination to form Ar1Ar2 [Ar1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; Ar2 = Ph, 4-MeOC6H4, 4-MeC6H4, etc.], and PhC(O)Ar [Ar = Ph, 3-MeOC6H4, 4-MeC6H4, etc.], R1NR2R3 [R1 = 4-OMe, 4-CF3; R2 = Ph, R3 = Me; R2R3 = CH2CH2OCH2CH2] resp.. Complex [Pd(IPr*)Cl(1-tBu-indenyl)], which borne the less electron-donating IPrCl ligand, showed the best performance on conventional Suzuki-Miyaura reaction of (aryl chlorides/arylboronic acids) and Buchwald-Hartwig amination using MeOH/THF and the green 2-MeTHF as solvents, resp. Moreover, for the challenging unconventional Suzuki-Miyaura reaction between esters and arylboronic acids, [Pd(IPr*)Cl(1-tBu-indenyl)] showed the highest activity among all catalysts tested. In the experiment, the researchers used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Recommanded Product: 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem