Category: 1403474-70-3

Synthetic Route of 1403474-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1403474-70-3, name is Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of azilsartan ester (VI; Ri= Et) (25 g) and 0.4 N NaOH solution (380 ml) was heated at 70-75C for 90 minutes. The reaction mixture was cooled to 10-15C and the pH was adjusted to 2.5-3.0 with 2 N HC1. The mixture was stirred for 30 minutes at 10- 15C. The solid was filtered, washed with water (100 ml) and dried under vacuum. Yield: 22.0 g;X-ray powder diffraction pattern as depicted in figure 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; ANSARI, Shahid, Akhtar; HIRPARA, Hitin, Maganbhai; BHATT, Nikhil, Shashikant; BARIA, Reenaben, Ratansing; YADAV, Ashok, Keshavlal; PATEL, Manishkumar, Baldevlal; WO2014/49512; (2014); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1403474-70-3, name is Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

Compound (5B) 5 g, placed in a reaction flask, adding ethanol 30ml, was added dropwise 2.5mol / L sodium hydroxide 13ml, 73-75 1.6 hours the reaction.After completion of the reaction, cooled to room temperature, the solution was added dropwise to the acidic water pH = 3-4, to precipitate a white solid 4.2g, 89.3%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Institute of pharmaceutical industry; Wang, Xiaomei; Sui, Qiang; Tang, Chao; Ouyang, Qunxiang; Shi, Huilin; Liu, Shuai; (18 pag.)CN103664920; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1403474-70-3 as follows. Application In Synthesis of Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Example 2 Preparation of the product 2-Ethoxy-3- [2 ‘- (5-oxo-4,5-dihydro- [1,2,4] oxadiazol-3-yl) 4-ylmethyl] -3H-benzimidazole-4-carboxylate 55.1 g,0.4 MN NaOH into the reaction bottle,75 C stirring reaction to the raw material reaction is completed. The reaction solution was cooled to room temperature. The filtrate was added with 820ml of absolute ethanol, filtered and kept at 20 C. The pH was adjusted to 1 with 2M HC1 solution. A large amount of solid was precipitated, stirred for 1 hour, filtered and washed with water. 50.6 g,HPL (^ i ^ S 98.6%

According to the analysis of related databases, 1403474-70-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hunan Xianjin Xiangjiang Pharmaceutical co., LTD; YUAN, XIUJU; YAO, LIANGYUAN; ZONG, AIJUN; DENG, MENGRU; (12 pag.)CN103664921; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1403474-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1403474-70-3, name is Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of azilsartan ester (VI; Ri= Et) (25 g) and 0.4 N NaOH solution (380 ml) was heated at 70-75C for 90 minutes. The reaction mixture was cooled to 10-15C and the pH was adjusted to 2.5-3.0 with 2 N HC1. The mixture was stirred for 30 minutes at 10- 15C. The solid was filtered, washed with water (100 ml) and dried under vacuum. Yield: 22.0 g;X-ray powder diffraction pattern as depicted in figure 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; ANSARI, Shahid, Akhtar; HIRPARA, Hitin, Maganbhai; BHATT, Nikhil, Shashikant; BARIA, Reenaben, Ratansing; YADAV, Ashok, Keshavlal; PATEL, Manishkumar, Baldevlal; WO2014/49512; (2014); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem