Category: 1402838-08-7

Application of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl 5-oxo-2-azaspiro[3.4]octane-2-carboxylate (2 g, 8.89 minol), 2-[ 1 -(triphenylmethyl)- I. H-iniidazol-4-y1]benzaldehyde (5.53 g, 13.34 mmol) and Ca(OH)2 (1.64g. 22.13 mniol) in EtOH (250 mL) was stirred for 6 hat 80C. The solids were filtered out. The solids were filtered out. The solvent was concentrated under vacuum. The residue was purified by silica gel column eluting with EtOAc /PE (1:2). This resulted in 5.24 g (95%) of tert-butyl (6E)-5-oxo-6-([2-[ 1 -(triphenyl.methyl)-1 H-imidazoi-4-yljphenyljmethylidene)-2-azaspiro[3.4]octane-2-carboxylate as a light yellow solid. LCMS (ESI)mJz = 622.8 [.M+Hr.

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1402838-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1402838-08-7 as follows.

2-(1-Trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (696 mg, 1.68 mmol, 1 eq),Compound ((5-(2-(Dimethoxyphosphoryl)acetyl)-6-fluorobenzofuran-2-yl)methyl) tert-butyl carbonate (0207-51) (772Mg, 1.85 mmol, 1.1 eq) andCesium carbonate (1090 mg, 3.36 mmol, 2 eq)Mixed in isopropanol (10 ml),The mixture was stirred at room temperature for 16 hours.After the reaction is completed, quench with water and filter to obtain the product ((6-Fluoro-5-(3-(2-(1-trityl-1H-imidazol-5-yl)phenyl)acryloyl)benzene. tert-Butyl furan-2-yl)methyl)carbonate (930 mg, crude) is a yellow solid

According to the analysis of related databases, 1402838-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

A slurry of tert-butyl 2?-oxospiro[8-azabicyclo[3 .2.1 ]octane-3, I ?-cyclobutanej-8-carhoxylate (2.65 g, 9.98 .mmol), 2-[ 1.-(triphenylmethyl)- IH-imidazol-4-yl.]benzaldehyde (4.55 g,11.0 mmol) and Ca(OH)2 (1.48 g, 20.0 mmol) in EtOH (33 mL) was stirred for 24 h at 80 C.The reaction was cooled to room temperature and insoluble material was removed by filtration. The filtrate was concentrated. The residue was purified by a silica gel column eluting withDCM/methanoj. (90:10) to afford 5.60 g (85%) tertbutyl E)-2?-oxo-3?(2-(1-trity1-1Wirnidazo1.-4-yl)benzylidene)-8-azaspiro[bicyclo{3 .2.1 ]octane-3, 1 ?-cyclobutane]-S-carboxylate as a pale yellow solid. LCM.S (ESI) m/z 662.3 [M+F1]4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1402838-08-7, its application will become more common.

Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde

Will (2-(2-phenylbenzofuran-5-yl)-2-oxoEthyl) dimethyl phosphate (0207-79) (254 mg, 0.738 mmol, 1.0 equiv),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (305 mg, 0.738 mmol, 1.0 equiv) andCesium carbonate (480 mg, 1.476 mmol, 2.0 equiv)The isopropanol solution (10 ml) was stirred overnight at room temperature.After the reaction is completed, quench with water, dichlorineMethane extraction, the organic phase is washed with saturated brine,It was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a yellow oil.The resulting yellow oil was purified by column chromatography on silica gel (eluent: ethyl acetate/petroleum ether = 1/2) to give the target product 1-(2-phenylbenzene)(Furan-5-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)propan-2-en-1-one (306 mg, Yield:65.7%) is a yellow oil.

The synthetic route of 2-(1-Trityl-4-imidazolyl)benzaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, A new synthetic method of this compound is introduced below., Safety of 2-(1-Trityl-4-imidazolyl)benzaldehyde

5-Acetylbenzofuran-2-carboxylic acid methyl ester (0506-89) (200 mg, 0.86 mmol, 1.0 equiv) and2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (534 mg, 1.3 mmol, 1.5 eq.)Soluble in ethanol (10 ml),Concentrated sulfuric acid 5 ml was added dropwise under ice bath conditions.The temperature was raised to 90C and the reaction was stirred for 18 hours.Cool to room temperature, add dropwise to ice water, add ice bath, add sodium hydroxide to adjust the pH>8, ethyl acetate extraction,The liquid was separated, spin-dried, and the crude product was purified by silica gel column chromatography (eluent: dichloromethane/methanol=200/1 to 40/1) to give the product 5-(2-(5H-imidazole)[5,1-a Ethyl isomorpholin-5-yl)acetyl)benzofuran-2-carboxylate (95 mg, 28.5%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde

In the atmosphere of nitrogen,Dimethyl methylphosphonate (402 mg, 3.24 mmol, 1.5 equiv)Dissolved in 5 ml of dry tetrahydrofuran.Cool to -60C with dry ice/ethanol.n-Butyllithium (1.70 ml, 2.5 mol/ml n-hexane solution, 4.32 mmol, 2 eq.) was slowly added dropwise.The mixture is stirred at this temperature for 30 minutes.The compound 6-fluoro-2-methylbenzofuran-5-carboxylic acid methyl ester (0303-69) (450 mg, 2.16 mmol, 1 eq.) was slowly added dropwise.A solution of tetrahydrofuran (5 ml).The mixture was stirred at this condition for 1 hour. Isopropanol (15 ml), cesium carbonate (1.0 g, 3.24 mmol, 1.5 eq) and 2-(1-Tri) were addedBenzyl-1H-imidazol-4-yl)benzaldehyde (0105-1) (894 mg, 2.16 mmol, 1 eq.) stirred at room temperatureAfter 16 hours, after the reaction was completed, water (50 ml) was added and the mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and anhydrous sulfuric acid.The sodium was dried, concentrated under reduced pressure, and purified by silica gel column chromatography to give the product 1-(6-fluoro-2-methylbenzofuran-5-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-en-1-one (530 mg, yield 41.9%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1402838-08-7.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde

2-(1-triphenylmethyl-1H-imidazol-4-yl)benzaldehyde (0105-1) (263 mg, 0.635 mmol, 1 eq),Compound (2-(6-Fluoro-2,3-dihydrobenzofuran-5-yl)-2-oxoethyl)phosphoric acid dimethyl ester (0403-42) (377 mg, 1.3 mmol, 1.3 eq. )And cesium carbonate (412 mg, 1.27 mmol, 2 eq.)Mixed in isopropanol (10 ml),The mixture was stirred at room temperature for 16 hours.After the reaction is completed, quench with water and filter to obtain the target product 1-(6-fluoro-2,3-dihydrobenzofuran-5-yl)-3-(2-(1-triphenylmethyl-1H-) Imidazol-5-yl)phenyl)prop-2-en-1-one (280 mg, crude) was a yellow solid.

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(1-Trityl-4-imidazolyl)benzaldehyde

In the atmosphere of nitrogen and ice bath conditions,Will be 60% sodium hydride (9.5 mg, 0.394 mmol, 2.0 equiv)Dissolved in 10 ml of tetrahydrofuran.The dimethyl 2-(furo[2,3-b]pyridin-5-yl)-2-oxoethyl)phosphate (0207-49) (53 mg, 0.197 mmol, 1.0 eq) was slowly addedTetrahydrofuran solution (10 ml).After stirring the mixture for 15 minutes,2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (82 mg, 0.197 mmol, 1.0 equiv)A solution of tetrahydrofuran (10 ml) was added dropwise.The mixture was stirred at ice bath for 0.5 hours.The reaction was warmed to room temperature and stirred overnight.After completion of the reaction, the mixture was quenched with a saturated aqueous solution of ammonium chloride and extracted with dichloromethane. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a yellow oil.The resulting yellow oil was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 1/2) to give the desired product.1-(Furano[2,3-b]pyridin-5-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-ene-1 -ketone (22 mg, yield: 20%) is a yellow oil

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C29H22N2O

Dimethyl (2-(quinoxalin-2-yl)-2-oxoethyl)phosphate (0803-134) (224 mg, 0.80 mmol, 1.1 eq),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (300 mg, 0.73 mmol, 1.0 equiv) andCesium carbonate (472 mg, 1.45 mmol, 2.0 eq.)Added to 40 ml of isopropanol,The reaction was stirred at room temperature overnight, concentrated under reduced pressure, ethyl acetate and water were added, and the mixture was separated and dried over anhydrous sodium sulfate.Shrink to give yellow solid product 1-(quinoxalin-2-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)propan-2-ene-1- Ketone (400 mg, crude product)

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1402838-08-7, These common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-Trityl-1H-imidazol-4-yl)benzaldehyde (4.0 g, 9.66 mmol) was dissolved in dry THF (20 mL)In a mixed solution with anhydrous EtOH (20 mL), cooled to 0 C, then EtONa (986 mg, 14.5 mmol), tert-butyl 4-acetylpiperidine-1-carboxylate (2.29 g, 10.1 mmol).Then the reaction solution was stirred at room temperature overnight, and the reaction was complete by LCMS.After that, it was diluted with ice water (30 mL), and the THF was evaporated under reduced pressure, and filtered, and the filter cake was drained as much as possible to obtain a crude white solid.(E)-4-(3-(2-(1-tritylmethyl-1H-imidazol-4-yl)phenyl)acryloyl)piperidine-1-carboxylic acid tert-butyl ester(6.0g), used directly in the next step.

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Weixin Biological Technology Co., Ltd.; Yu Jindi; Lu Xianping; Li Zhibin; Xin Lijun; Zhu Jiangfei; Fu Chao; (67 pag.)CN108203438; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem