Category: 13750-81-7

Synthetic Route of 13750-81-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13750-81-7, name is 1-Methyl-1H-imidazole-2-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 76A1 -Ethyl- lH-imidazole-2- carbaldehyde[00631] To a suspension of lH-imidazole-2- carbaldehyde (480 mg, 5 mmol) and potassium carbonate (936 mg, 6 mmol) in N, N-dimethylformamide (7 mL) was added iodoethane (829 mg, 6mmol) and the mixture was heated at 50 C for 5 hrs. Solvent was removed under reduced pressure. The residue was partitioned between water (30 mL) and ethyl acetate (30 mL). The aqueous layer was extracted with ethyl acetate (20 mLx3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give 1 -ethyl- lH-imidazole-2- carbaldehyde as light yellow oil (520 mg, yield 84%). 1H MR (400 MHz, CDC13) delta (ppm): 1.42- 1.46 (t, J= 7.2 Hz, 3H), 4.42-4.47 (q, 2H), 7.19 (s, IH), 7.29 (s, IH), 9.82 (s, IH). LC-MS (ESI) m/z: 125 (M+l)+.

The synthetic route of 1-Methyl-1H-imidazole-2-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 13750-81-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13750-81-7, name is 1-Methyl-1H-imidazole-2-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

First, 1-methylimidazole-2-carboxaldehyde was prepared according to the literature procedure[23]. The synthesis procedure then followed that of Im2COOH (1b) above and the yield was also quantitative after the removal of water under high vacuum (no washing with diethylether/water was necessary). Note: heating causes decarboxylation. Yield: 100%. Mp=99-101C. deltaH (400MHz, D2O): 7.42, 7.39 (2H, s, Im-H) and 4.08ppm (3H, s, NCH3); deltaC (400MHz, D2O): 158.67, 139.68, 125.83, 118.46, 36.73ppm. IR nu (KBr): 3347(m) 3119(m), 2663(w), 1641(s), 1683(m), 1507(s), 1449(m), 1388(s), 1338(s), 1285(s), 1173(m), 1123(s), 961(m) 910(m), 776(s), 685(s) cm-1. Anal. Calc. for C5H8N2O3 (144.12); C, 41.67; H, 5.59; N, 19.44%. Found: C, 41.28; H, 5.23; N, 19.12%.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-imidazole-2-carbaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Article; Gundhla, Isaac Z.; Walmsley, Ryan S.; Ugirinema, Vital; Mnonopi, Nandipha O.; Hosten, Eric; Betz, Richard; Frost, Carminita L.; Tshentu, Zenixole R.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 11 – 18;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem