Category: 13750-62-4

Electric Literature of 13750-62-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13750-62-4 as follows.

General procedure: An appropriate imidazole (0.2 mmol) was added to the mixtureof [Pd(mu-X)X(bmim-y)]2 (0.1 mmol) in CH2Cl2 (1-2 ml). The colorchanged from orange to yellow immediately (in case of iodidecomplex from dark red to red). The mixture was stirred for 1 h atroom temperature. After this time 8ml of a hexane was added tothe solution and clouding of the mixturewas observed. The mixturewas left for 24 h and the yellow solid was formed. The product wasfiltrated, washed with hexane and dried. The complexes were obtainedwith the yield of 80-90%.

According to the analysis of related databases, 13750-62-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sikorski; Zawartka; Trzeciak; Journal of Organometallic Chemistry; vol. 867; (2018); p. 323 – 332;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C11H12N2

General procedure: 2.3. Typical procedure for the synthesis of imidazolium ion tethered TsDPENs 5a. A solution mixture of the intermediate 3 (818 mg, 1.5 mmol) and 1,2-dimethyl-1H-imidazole (173 mg, 1.8 mmol) in acetonitrile (2 mL) was heated at 70 C for 30 h. The solvent was removed under reduced pressure, and the residue was washed with a mixture solvent (hexane/ethyl acetate = 10:1) and dried in vacuo to give an intermediate 4a, to which HCl solution (3 mL, 4 M in dioxane) was added. The reaction mixture was stirred at room temperature for 5 h and the precipitation was filtered and washed with hexane to give the Boc deprotected intermediate, which was used for the next step directly without further characterization. The Boc-deprotected intermediate was subsequently neutralized by Na2CO3 (159 mg, 1.5 mmol) in MeOH (2 mL). The mixture was stirred for 5 h and the solvent was removed to dryness. The solid residue was dissolved in dry CH2Cl2 and filtered, and concentrated to give the product 5a as a white solid (550 mg, 68% yield for 2 steps).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kang, Guowei; Lin, Silong; Shiwakoti, Atul; Ni, Bukuo; Catalysis Communications; vol. 57; (2014); p. 111 – 114;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Benzyl-2-methyl-1H-imidazole

General procedure: A solution mixture of the intermediate 3 (818 mg, 1.5 mmol) and 1,2-dimethyl imidazole (173 mg, 1.8 mmol) in acetonitrile (2 mL) was heated at 70 C for 30 h. The solvent was removed under reduced pressure, and the residue was washed with a mixture solvent (hexane/ethyl acetate = 10:1) and dried in vacuo to give an intermediate 4a, to which HCl solution (3 mL, 4 M in dioxane) was added. The reaction mixture was stirred at room temperature for 5 h and the precipitation was filtered and washed with hexane to give the Boc deprotected intermediate, which was used for the next step directly without further characterization. The Boc deprotected intermediate was subsequently neutralized by Na2CO3 (159 mg, 1.5 mmol) in MeOH (2 mL). The mixture was stirred for 5 h and the solvent was removed to dryness. The solid residue was dissolved in dry CH2Cl2 and filtered, and concentrated to give the product 5a as a white solid (550 mg, 68% yield for 2 steps).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kang, Guowei; Lin, Silong; Shiwakoti, Atul; Ni, Bukuo; Catalysis Communications; vol. 57; (2014); p. 111 – 114;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 13750-62-4, A common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, molecular formula is C11H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1-Benzyl-2-methylimidazole (0.32 cm3, ?2 mmol) was dissolved in acetonitrile (10 cm3) and then slowly added to warm solution of PdCl2 (0.18 g, 1 mmol) (in the synthesis of thiocyanate complex the NH4SCN (0.15 g, 2 mmol) was added) in acetonitrile (30 cm3). The mixture was refluxed for about 2 h and after the time the reaction solution was filtered and yellow single crystals were obtained by slow evaporation of the solvent. Yield: 88% for chloride complex (1) and 92% for thiocyanate analog (2).(0006)(1): IR (KBr): 3155 nuArH; 2927 nuCH; 1543 nuCN, 1497 nuC=C; 1454, 1351 delta(C-CH in the plane); 1274, 1155 delta(N-CH in the plane); 1067 delta(CH3); 750, 695 delta(Im ring).(0007)1H NMR (400 MHz, CDCl3) delta 7.43-7.26 (m, Ph), 7.17 (d, J = 1.8 Hz, Im), 7.13-7.06 (m, Ph), 6.74 (d, J = 1.8 Hz, Im), 5.03 (s, CH2), 2.92 (s, CH3).(0008)UV-Vis (acetonitrile, lambda (nm): 401.5, 276.1, 228.4, 211.5.

The synthetic route of 13750-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma?ecki; Maro?; Polyhedron; vol. 50; 1; (2013); p. 452 – 460;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 13750-62-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13750-62-4 as follows.

General procedure: An appropriate imidazole (0.2 mmol) was added to the mixtureof [Pd(mu-X)X(bmim-y)]2 (0.1 mmol) in CH2Cl2 (1-2 ml). The colorchanged from orange to yellow immediately (in case of iodidecomplex from dark red to red). The mixture was stirred for 1 h atroom temperature. After this time 8ml of a hexane was added tothe solution and clouding of the mixturewas observed. The mixturewas left for 24 h and the yellow solid was formed. The product wasfiltrated, washed with hexane and dried. The complexes were obtainedwith the yield of 80-90%.

According to the analysis of related databases, 13750-62-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sikorski; Zawartka; Trzeciak; Journal of Organometallic Chemistry; vol. 867; (2018); p. 323 – 332;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 13750-62-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 6; Tetra(1-benzyl-2-methylimidazolium) salt; To a solution of hydroxy gallium(III) naphthalocyaninetetrasulfonic acid (2.60 g, 2.33 mmol) in water (5 mL) and methanol (100 mL) was added 1-benzyl-2-methylimidazole (2.0 mL, 2.16 g, 0.013 mol) and then the reaction mixture was evaporated to dryness with heating and stirring under a stream of nitrogen. The residue was suspended in water (200 mL) and filtered, washed with water (2×200 mL) and air-dried. The solid was then washed with diethyl ether (2×200 mL) and dried to give the product as a green powder (2.95 g, 70%).1H NMR (d6-DMSO) 2.57 (12H, s); 5.37 (8H, s); 7.30-7.45 (20H, m); 7.55 (4H, d, J=2.1 Hz); 7.63 (4H, d, J=2.1 Hz); 8.0-11.5 (20H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-2-methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference of 13750-62-4,Some common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, molecular formula is C11H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1-Benzyl-2-methylimidazole (0.32 cm3, ?2 mmol) was dissolved in acetonitrile (10 cm3) and then slowly added to warm solution of PdCl2 (0.18 g, 1 mmol) (in the synthesis of thiocyanate complex the NH4SCN (0.15 g, 2 mmol) was added) in acetonitrile (30 cm3). The mixture was refluxed for about 2 h and after the time the reaction solution was filtered and yellow single crystals were obtained by slow evaporation of the solvent. Yield: 88% for chloride complex (1) and 92% for thiocyanate analog (2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Benzyl-2-methyl-1H-imidazole, its application will become more common.

Reference:
Article; Ma?ecki; Maro?; Polyhedron; vol. 50; 1; (2013); p. 452 – 460;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 13750-62-4

General procedure: A 16 mL vial with a PTFE/silicone septum and a nitrogen-bubbler line was charged with N-benzylbenzimidazole (208.1 mg, 1.0 mmol), Pd/C (10 wt %, dry powder, reduced) (20 mg) and THF (5 mL). The mixture was treated at rt with triethylsilane (320 muL, 2.0 mmol) and then stirred under nitrogen for 14 h at rt. The mixture was filtered through a 0.45 muM PTFE syringe filter and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (0 to 10% MeOH/ dichloromethane) to afford benzimidazole as a colorless solid (117.6 mg, 0.996 mmol 99%). The reactions generally exhibit an induction period of 5 to 30 min as indicated by the initiation of gas release (i.e., bubbling) from the reaction mixture. The use of Pd/C on a dry matrix is imperative as wet Pd/C results in decreased yield or no reaction.

The synthetic route of 13750-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Graham, Thomas H.; Tetrahedron Letters; vol. 56; 21; (2015); p. 2688 – 2690;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 13750-62-4, These common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1-BENZYL-2-METHYL-1H IMIDAZOLE] (50 mg, 0.3 mmol) and 3,4-dichlorobenzyl bromide (77 mg, 0.32 mmol) in 0.2 ml acetonitrile (a few drops of DMF were added for solubility) were stirred overnight at room temperature. The mixture was diluted with ether, the solid filtered, washed with ether and dried to give 112 mg of product. LC/MS (ES+) m/e 333 [[M+1]]

The synthetic route of 13750-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/101970; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, molecular formula is C11H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 13750-62-4.

The 1-benzyl-2-methylimidazole (0.64 cm3, ?4 mmol) was added to the solution of NiCl2¡¤6H2O (0.24 g, ?1 mmol) and NH4SCN (0.15 g, 2 mmol) in methanol (50 cm3). The mixture was refluxed for about 2 h and after the time the reaction solution was filtered and blue single crystals were obtained by slow evaporation of the solvent.(0013)(3): IR (KBr): 3119, 3030 nuArH; 2954 nuCH; 2094 nu(CN from SCN); 1537 nuCN, 1495 nuC=C; 1451, 1415 1351 delta(C-CH in the plane); 1280, 1140 delta(N-CH in the plane); 988 delta(CH3); 726 nu(SC from SCN).(0014)UV-Vis (methanol, lambda (nm): 1069.7, 647.8, 414.5, 267.6, 264.3, 258.2, 252.2, 247.2, 211.4.

The synthetic route of 1-Benzyl-2-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma?ecki; Maro?; Polyhedron; vol. 50; 1; (2013); p. 452 – 460;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem