Category: 136117-70-9

Computed Properties of C8H5N3On October 10, 2016 ,《Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles》 was published in ACS Combinatorial Science. The article was written by Tolmachev, Andrey; Bogolubsky, Andrey V.; Pipko, Sergey E.; Grishchenko, Alexander V.; Ushakov, Dmytro V.; Zhemera, Anton V.; Viniychuk, Oleksandr O.; Konovets, Anzhelika I.; Zaporozhets, Olga A.; Mykhailiuk, Pavel K.; Moroz, Yurii S.. The article contains the following contents:

One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chem. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole, I, and agonists of free fatty acid receptor 1. A library of 4,948,100 synthesizable drug-like 3,5-disubstituted 1,2,4-oxadiazoles was enumerated based on the method and available validated reagents. The results came from multiple reactions, including the reaction of Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Computed Properties of C8H5N3)

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Computed Properties of C8H5N3 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition》 was written by Reich, Siegfried H.; Sprengeler, Paul A.; Chiang, Gary G.; Appleman, James R.; Chen, Joan; Clarine, Jeff; Eam, Boreth; Ernst, Justin T.; Han, Qing; Goel, Vikas K.; Han, Edward Z. R.; Huang, Vera; Hung, Ivy N. J.; Jemison, Adrianna; Jessen, Katti A.; Molter, Jolene; Murphy, Douglas; Neal, Melissa; Parker, Gregory S.; Shaghafi, Michael; Sperry, Samuel; Staunton, Jocelyn; Stumpf, Craig R.; Thompson, Peggy A.; Tran, Chinh; Webber, Stephen E.; Wegerski, Christopher J.; Zheng, Hong; Webster, Kevin R.. Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile And the article was included in Journal of Medicinal Chemistry on April 26 ,2018. The article conveys some information:

Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphorylation of eIF4E and other mRNA binding proteins. Modulation of these key effector proteins regulates mRNA, which controls tumor/stromal cell signaling. Compound 23 (eFT508, 6′-((6-aminopyrimidin-4-yl)amino)-8′-methyl-2’H-spiro-[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione hydrochloride), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation. The crystal structure-guided design leverages stereoelectronic interactions unique to MNK culminating in a novel pyridone-aminal structure described for the first time in the kinase literature. Compound 23 has potent in vivo antitumor activity in models of diffuse large cell B-cell lymphoma and solid tumors, suggesting that controlling dysregulated translation has real therapeutic potential. Compound 23 is currently being evaluated in Phase 2 clin. trials in solid tumors and lymphoma. Compound 23 is the first highly selective dual MNK inhibitor targeting dysregulated translation being assessed clin. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile)

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yamanaka, Motosuke; Miyake, Kazutoshi; Suda, Shinji; Ohhara, Hideto; Ogawa, Toshiaki published their research in Chemical & Pharmaceutical Bulletin on December 31 ,1991. The article was titled 《Imidazo[1,2-a]pyridines. I. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives. [Erratum to document cited in CA115(15):159040c]》.Recommanded Product: 136117-70-9 The article contains the following contents:

An error in Chart 3 has been corrected An error in Table III has been corrected Three errors in the text have been corrected The errors were not reflected in the abstract but were reflected in the index entries. After reading the article, we found that the author used Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Recommanded Product: 136117-70-9)

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 136117-70-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2020,Journal of Materials Chemistry C: Materials for Optical and Electronic Devices included an article by Young, David C.; Tasior, Mariusz; Laurent, Adele D.; Dobrzycki, Lukasz; Cyranski, Michal K.; Tkachenko, Nikolai; Jacquemin, Denis; Gryko, Daniel T.. Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile. The article was titled 《Photostable orange-red fluorescent unsymmetrical diketopyrrolopyrrole-BF2 hybrids》. The information in the text is summarized as follows:

The straightforward synthesis of structurally unique DPP-BODIPY hybrids was developed using unsym., imidazopyridine substituted diketopyrrolopyrroles (DPPs). These hybrids exhibit a superb combination of photophys. properties including high photostability, good fluorescence quantum yield as well as markedly bathochromically shifted absorption and emission compared to conventional diketopyrrolopyrroles. Increasing the size of the imidazopyridine substituent and/or the electron donating power of the other aryl substituent can further red shift both absorption and emission to reach ∼650 nm for the free-base and ∼700 nm for B-chelates. A strong intramol. H bond is responsible for the small change in geometry between the ground and excited states and hence relatively small differences in photophys. properties upon formation of B-chelates are observed The solvent dependence of the photophys. properties for the free base and DPP-BF2 complexes were studied and show strong fluorescence with long lifetimes in both nonpolar and polar aprotic environments. In addition to this study using Imidazo[1,2-a]pyridine-8-carbonitrile, there are many other studies that have used Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile) was used in this study.

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem