Category: 13435-22-8

Reference of 13435-22-8,Some common heterocyclic compound, 13435-22-8, name is 1-Butyl-2-methyl-1H-imidazole, molecular formula is C8H14N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ex is of a 1-butyl-2-methyl-3(propyl-3-sulfonyl) imidazolium 1-Butyl-2-methylimidazol (710 mg, 0.9 mmol, 1 equivalent) was dissolved in 10 ml toluene and propanesultone (610 mg, 0.9 mmol, 1 equivalent) was added. The clear solution was heated at reflux temperature for 3h at which time a some withe precipitate was formed. The reaction mixture was cooled to room temperature and the white suspension was then filtered and washed with 5 ml toluene. The white solid was dried under high vacuum at 60C for 4 h, yielding the desired product (89 mg, 38% yield). H NMR analysis confirms the structure and a purity of >98 %. Melting point by DSC: 160 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Butyl-2-methyl-1H-imidazole, its application will become more common.

Reference:
Patent; ECOLE D’INGENIEURS ET D’ARCHITECTES DE FRIBOURG; MARTI, Roger; VANOLI, Ennio; AEBY, Sandrine; FISCHER, Fabian; HAPPE, Manuel; WO2013/8172; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13435-22-8, name is 1-Butyl-2-methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Butyl-2-methyl-1H-imidazole

General procedure: 1,2-Dimethyl imidazole (9.61 g; 0.10 mol) and trimethylphosphate (14.01 g; 0.10 mol) were mixed at room temperature under argon and vigorous stirring, then heated to 80C and stirred at this temperature for 1h. Acetonitrile (20 mL) was added and the mixture was stirred at 80C for 23h. The mixture was left at room temperature, the precipitate was separated,washed twice with acetonitrile and dried under vacuum (2 Torr) for 4 h at 80C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13435-22-8.

Reference:
Article; Zicmanis, Andris; Anteina, Liene; Tetrahedron Letters; vol. 55; 12; (2014); p. 2027 – 2028;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 13435-22-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13435-22-8, name is 1-Butyl-2-methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2.3. Typical procedure for the synthesis of imidazolium ion tethered TsDPENs 5a. A solution mixture of the intermediate 3 (818 mg, 1.5 mmol) and 1,2-dimethyl-1H-imidazole (173 mg, 1.8 mmol) in acetonitrile (2 mL) was heated at 70 C for 30 h. The solvent was removed under reduced pressure, and the residue was washed with a mixture solvent (hexane/ethyl acetate = 10:1) and dried in vacuo to give an intermediate 4a, to which HCl solution (3 mL, 4 M in dioxane) was added. The reaction mixture was stirred at room temperature for 5 h and the precipitation was filtered and washed with hexane to give the Boc deprotected intermediate, which was used for the next step directly without further characterization. The Boc-deprotected intermediate was subsequently neutralized by Na2CO3 (159 mg, 1.5 mmol) in MeOH (2 mL). The mixture was stirred for 5 h and the solvent was removed to dryness. The solid residue was dissolved in dry CH2Cl2 and filtered, and concentrated to give the product 5a as a white solid (550 mg, 68% yield for 2 steps).

The chemical industry reduces the impact on the environment during synthesis 1-Butyl-2-methyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13435-22-8, name is 1-Butyl-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C8H14N2

1.86 g (5 mmol) of dysprosium oxide was dissolved in about 51 mmol of a 25% by volume aqueous solution of nitric acid,Stirring until completely dissolved,Further, 2.76 g (20 mmol) of 1-butyl-2-methylimidazole,60 reaction conditions 18h,The solvent was evaporated,To give 7.50 g of a light yellow transparent liquid 1-butyl-2-methylimidazole penta nitryloidate ion liquid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sichuan University; Tao, Guohong; Tang, Ning; He, Ling; (16 pag.)CN106146541; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem