Category: 131020-36-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131020-36-5, name is Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Formula: C10H10N2O2

1-METHYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID : H20 (100 mL) was added to a solution of methyl 1-METHYL-1H-BENZOIMIDAZOLE-5-CARBOXYLATE (10.00 g, 52.6 MMOL) in 1 N LiOMe in MEOH (100 mL, 100 MMOL). The resulting solution was stirred under an inert atmosphere and monitored to completion BY 1H NMR.Aqueous 1 N HCI (100 mL, 100 MMOL) was added dropwise to the reaction mixture cooled with an ice-water bath. The gray solid which formed was collected by filtration and washed with water followed with methanol. Vacuum drying afforded 8.60 g of desired PRODUCT.1H NMR (300 MHZ, D6-DMSO) B 12.75 (br s, 1 H), 8.31 (s, 1 H), 8.23 (s, 1 H), 7.89 (d, J=8.36 Hz, 1 H), 7.62 (d, J=8.35 Hz, 1 H), 3.85 (s, 3 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/99131; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131020-36-5, name is Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

Example 11B : 5-Hydroxymethyl-l-methylbenzimidazole A solution of methyl [L-METHYLBENZIMIDAZOLE-5-CARBOXYLATE] (1.6 g, 8.42 mmol) in dry THF (80 mL) was treated with [LIALH4] (1.59 g, 42.1 mmol) and the mixture stirred for 2 hours. 1.5 mL of 5% [NAOH] solution was then added, and the solid which precipitated was filtered through diatomaceous earth. The filtrate was collected and the solvent removed under reduced pressure to give 0. [8] g of the title compound. [C9HLON20] NMR (400 MHz, DMSO-d6): 3.85 (3H, s, NCH3) ; 4.65 (2H, s, [CH20H)] ; 5.25 [(1H,] bs, OH); 7.3 [(1H,] dd, [J =] 1 and [8] Hz, aryl-H); 7.55 [(1H,] d, [J] [=] [8] Hz, aryl-H); 7.65 [(1H,] d, J= 1 Hz, aryl-H); 8.2 [(1H,] s, imidazole-H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN, INC.; WO2003/99814; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131020-36-5, name is Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

The methyl 1-methyl-1H-benzimidazole-5-carbonate (500 mg) obtained above was dissolved in methanol (10 ml). 1 N Sodium hydroxide solution (8 ml) was added thereto, and the mixture was stirred for 4 hours at room temperature. Water was added to the reaction mixture which was then acidified by formic acid. Precipitates were collected by filtration and dried under reduced pressure to give the title compound (367 mg, Y.: 79%). 1H NMR; (DMSO-d6) delta (ppm): 3.8 (s, 3H), 7.6 (d, 1H), 7.8 (dd, 1H), 8.2 (d, 1H), 8.3 (s, 1H).

The synthetic route of 131020-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANWA KAGAKU KENKYUSHO CO., LTD.; EP1595866; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131020-36-5, name is Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 131020-36-5

1-METHYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID : H20 (100 mL) was added to a solution of methyl 1-METHYL-1H-BENZOIMIDAZOLE-5-CARBOXYLATE (10.00 g, 52.6 MMOL) in 1 N LiOMe in MEOH (100 mL, 100 MMOL). The resulting solution was stirred under an inert atmosphere and monitored to completion BY 1H NMR.Aqueous 1 N HCI (100 mL, 100 MMOL) was added dropwise to the reaction mixture cooled with an ice-water bath. The gray solid which formed was collected by filtration and washed with water followed with methanol. Vacuum drying afforded 8.60 g of desired PRODUCT.1H NMR (300 MHZ, D6-DMSO) B 12.75 (br s, 1 H), 8.31 (s, 1 H), 8.23 (s, 1 H), 7.89 (d, J=8.36 Hz, 1 H), 7.62 (d, J=8.35 Hz, 1 H), 3.85 (s, 3 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/99131; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 131020-36-5, A common heterocyclic compound, 131020-36-5, name is Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of ( 1 -methyl- l H-benzimidazol- – l methanolThe title compound was synthesized by esterification of l//-benzimidazole-5-carboxylic acid using methanol in presence of cone, sulphuric acid followed by N-methylation using methyl iodide in presence of potassium carbonate and subsequent reduction of the ester group by lithium aluminium hydride; NMR (300 MHz, DMSO- 6) delta 3.84 (s, 3H), 4.59 (s, 2H), 5.23 (br s, l H), 7.26 (d, J = 8.4 Hz, 1H), 7.52-7.58 (m, 2H), 8.23-8.31 (m, 1 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; LINGAM, Prasada, Rao, V., S.; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; BAJPAI, Malini; GULLAPALLI, Srinivas; DAHALE, Dnyaneshwar, Harishchandra; MINDHE, Ajit, Shankar; RATHI, Vijay, Eknath; WO2011/138657; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem