The relationship between the binding of 2-n-alkylbenzimidazoles to rat hepatic microsomal cytochrome P 450 and the inhibition of monooxygenation was written by Dickins, Maurice;Bridges, James W.. And the article was included in Biochemical Pharmacology in 1982.Category: imidazoles-derivatives This article mentions the following:
The binding of an homologous series of 2-n-alkylbenzimidazoles to cytochrome聽P聽450聽聽[9035-51-2] in control, phenobarbitone-, or 20-methylcholanthrene-induced rat hepatic microsomal preparations produced Type I, Type RI, and mixed Type I/RI spectra. Alkyl chain length affected spectral type, as did substrate concentration and microsomal source. An optimal chain length of C7-C8 was observed for Type I binding, longer side chains decreasing the affinity. The apparent spectral binding constants for the Type I site only were closely associated with the Ki and I50 values for the inhibition of cytochrome P 450-dependent monooxygenation. From their inhibition properties, even the short chain substituted benzimidazoles also appeared to bind to the Type I site and thus compete for the substrate binding site of cytochrome P 450. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Category: imidazoles-derivatives).
2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem