Category: 128293-62-9

Adding a certain compound to certain chemical reactions, such as: 128293-62-9, name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 128293-62-9, HPLC of Formula: C7H11N3O2

The compound 7 was dissolved in methanol (94.4 ml), mixed with 10 % Pd/C (1.18 g) and stirred for four hours under hydrogen atmosphere. 10% Pd/C was removed from the reaction system with cerite filtration, so that the solvent was distilled out under a reduced pressure. Dimethylformamide (10 ml) was added to the residue and distilled out again under a reduced pressure. The residue was dissolved in dimethylformamide (10 mL) again, and mixed with the compound 8 (5. 9 g, 23.6mmol) (Baird, E. E. ; Dervan, P. B. J. Org. Chem. 1996, 118, 6141-6146), EDC (9.05 g, 47.2 mmol) and dimethylaminopyridine (288 mg, 2. 36 mmol), and stirred for 12 hours at a room temperature. Re-precipitation treatment with chloroform and ethyl acetate gave the compound 9 as white powder (5.9 g, 63%). 1HNMR(DMSO-d6) delta 1.28-1.30 (3H, t, J = 7.1 Hz), 3.85(3H, s), 3.93(3H, s), 3.98(3H, s), 4.25-4.29 (2H, dd, J = 7.1 Hz), 7.03(1H, d, J = 0.7 Hz), 7.22(1H, d, J = 2.0 Hz), 7.38(1H, s), 7.38(1H, s), 7.66(1H, s), 10.35(1H, s), 10.74(1H, s) ; 13CNMR(DMSO-d6) delta 14.3, 35.3, 35.7, 36.5, 60.8, 106.4, 115.6, 119.8, 121.6, 122.2, 126.5, 127.2, 131.0, 138.0, 139.0, 156.3, 158.7, 158.9: Anal. Calcd. for C18H12N4O3·H2O: C, 53.22; H, 4.89; N, 22.57. Found: C, 50.88; H,4.88; N,23.13.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Japan Science and Technology Agency; EP1719777; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 128293-62-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 128293-62-9, name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To Im-3 (0. 38 g) in DMF (8 mL) and Hunig’s base (2ML) was added ditert-butyl dicarbonate (0.7 ml) and the mixture stirred at 60 C for 3 hr. It was then cooled to room temperature and brine (6 ML) and ethyl ether (6 ML) were added. The ether layer was extracted with 10% citric acid, brine, saturated sodium bicarbonate, and brine (10 mL each). The ether layer was then dried over sodium sulfate and evaporated under vacuum. NAOH (1M, 5mL) in methanol was then added and solution stirred at 60 C for 1 hr. The mixture was then cooled to 0 C and neutralised with 1M HC1 to pH 2 at which a white gel was formed. The gel was collected by gravity filtration and washed with water pH=6 before it was freeze dried to yield the product as a white powder. Yield (0.41 g, 76%). 1H NMR (DMSO): 6 9.45 (bs, 1H, NH), 7.21 (bs, 1H), 3. 86 (s, 3H), 3.67 (bs, 1H, OH), 1.4 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF WESTERN SYDNEY; WO2005/33077; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 128293-62-9,Some common heterocyclic compound, 128293-62-9, name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 231: N-[2-(tert-butylcarbamoyl)-1-methyl-1H-imidazol-4-yl]-4,4-dimethyl- l-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxamide Step 1: Synthesis of ethyl 4-{[(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2- a]indol-7-yl)carbonyl]amino}-1-methyl-1H-imidazole-2-carboxylateTo a solution of 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7- carboxylic acid (336 mg, 1.3 mmol, Intermediate E) in DMF (1 mL) are added N- hydroxybenzotriazole (351 mg, 2.6 mmol) and l-ethyl-3-(3-dimethylaminopropyl) carbodiimide (498 mg, 2.6 mmol). After stirring for 10 min, 4-amino-1-methyl-lH- imidazole-2-carboxylic acid ethyl ester (535 mg, 2.6 mmol), N,N-diisopropylethylamine (0.45 mL, 2.6 mmol) and 4-dimethylaminopyridine (32 mg, 0.26 mmol) are added. The reaction mixture is heated at 60 C for 16 h. DMF is removed under a stream of N2 at 40 C and EtOAc (2 mL) and water (2 mL) are added. After stirring for 15min, a white solid is formed and it is filtered and dried to afford the title compound (490 mg, 92%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong; WO2011/71716; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem