Category: 1255717-13-5

On September 23, 2021, Kim, Young Kwan; Jo, Min Mi; Park, Jun published a patent.Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride The title of the patent was Preparation of GLP-1 receptor agonist for treatment or prophylaxis of various metabolic diseases. And the patent contained the following:

The present invention relates to a novel compound I [A = (CH2)m, O, N(Ra) where m = 1-3; Ra = hydrogen, alkyl; R1 = (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl; R2-R4 = hydrogen, deuterium, halogen, etc.; n = 1-4; Z1-Z7 = CH, CF, CCl, CBr, CI, N; isomer or pharmaceutically acceptable salt thereof] useful as an agent for treatment or prophylaxis of various metabolic diseases such as obesity or diabetes and hyperlipidemia, by means of excellent GLP-1 agonist activity and an excellent DMPK profile. For example II was prepared and exhibited EC50 of 0.007 nM against GLP-1R. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

The Article related to preparation glp 1 receptor agonist treatment prophylaxis metabolic disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 13, 2019, Aspnes, Gary Erik; Bagley, Scott W.; Curto, John M.; Edmonds, David James; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David W.; Riggeri, Roger B. published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists for the treatment of diseases. And the patent contained the following:

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof. The example compound (I) was prepared by multistep synthesis (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). The compounds of the invention can be used in treatment of diseases, such as NASH, diabetes, obesity and like. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Category: imidazoles-derivatives

The Article related to benzimidazole carboxylic acid salt preparation glp1r agonist disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 19, 2019, Aspnes, Gary Erik; Bagley, Scott W.; Conn, Edward L.; Curto, John M.; Edmonds, David James; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Limberakis, Chris; Mathiowetz, Alan M.; Piotrowski, David W.; Ruggeri, Roger B. published a patent.Electric Literature of 1255717-13-5 The title of the patent was GLP-1 receptor agonists and uses thereof. And the patent contained the following:

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza- benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Electric Literature of 1255717-13-5

The Article related to glp1 receptor agonist benzimidazole preparation cardiometabolic disease, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Electric Literature of 1255717-13-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 26, 2020, Aspnes, Gary E.; Bagley, Scott W.; Curto, John M.; Dowling, Matthew; Edmonds, David James; Fernando, Dilinie; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David Andrew; Huard, Kim; Ingle, Gajendra; Jiao, Wenhua; Lacasse, Shawn M.; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David Walter; Ruggeri, Roger B.; Wiglesworth, Kristin published a patent.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride The title of the patent was Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases and their preparation. And the patent contained the following:

The invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepatitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein. Example compound I•TFA was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their GLP-1R agonistic activity (some data given). The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

The Article related to benzodioxole preparation glp 1r agonist treatment nash nafld, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 10, 2022, Meng, Qinghua; Lei, Hui; Zhang, Haizhen; Lin, Xichen; Jennings, Andrew published a patent.Computed Properties of 1255717-13-5 The title of the patent was Heterocyclic GLP-1 agonists. And the patent contained the following:

This disclosure relates to GLP-1 agonists of Formula I, including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Computed Properties of 1255717-13-5

The Article related to heterocyclic glp1 agonist preparation treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 1255717-13-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem