Adding a certain compound to certain chemical reactions, such as: 1245649-58-4, name is 6-Bromo-1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1245649-58-4, Recommanded Product: 1245649-58-4
A mixture of compound 6-bromo-l-(tetrahydro-2H-pyran-4-yl)-lH- benzo[d] imidazole (68 mg, 0.243 mmol), l-(3,4-dihydroisoquinolin-2(lH)-yl)-3-((4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)propan-2-ol (100 mg, 0.243 mmol), Pd(dppf)Cl2 (17.8 mg, 0.026 mmol) and K2C03 (101 mg, 0.734 mmol) in H20-dioxane (1 mL/ 3 mL) was stirred at 100C under N2 with microwave mediated heating for 15 min. The solvent was then removed by concentration and the crude product purified by pre-HPLC to give the title compound as the formate salt (11.8 mg, yield: 10.1%). 1H NMR (500 MHz, MeOD): delta 8.44 (s, 1H), 7.98 (s, 1H), 7.90 (d, J = 5.6 Hz, 1H), 7.79 (d, J = 8.8 Hz, 1H), 7.63 (d, J = 1.6 Hz, 1H), 7.35-7.27 (m, 3H), 7.21 (d, J = 7.6 Hz, 1H), 7.04-7.02 (m, 2H), 4.82-4.76 (m, 1H), 4.45 (s, 2H), 4.35 (br.s, 1H), 4.18 (dd, J = 4.0, 11.2 Hz, 2H), 3.75-3.52 (m, 6H), 3.33 (br, 2H), 3.23 (br.s, 2H), 2.31-2.15 (m, 4H)ppm; ESI-MS (m/z): 484.3 [M+l] +.
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Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100695; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem