124312-73-8 Archives - Imidazoles-derivatives

S News Analyzing the synthesis route of 124312-73-8

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 124312-73-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., name: (1-Methyl-1H-imidazol-2-yl)methanamine

Method B. A solution of 8 (0.247 g, 1.17 mmol) in MeOH (20 mL) was treated sequentially with 2-aminomethyl-1-methylimidazole (0.059 g, 0.53 mmol) and NaBH3CN (0.07 g, 1 mmol). The reaction mixture was stirred at room temperature overnight and the solvent was removed under vacuum yielding L2 a yellow oil. The crude product was purified as described in method A with similar isolated yields. IR (KBr) 3052 cm-1 (amide-NH), 1667 cm-1 (amide-C=O); 1H NMR CD2Cl2 delta 7.81 (s, AmIm(N-H)), 7.09 (s, 2, AmIm(H-5)), 6.80 (s, 1, Im(H-5)), 6.75 (s, 1, Im(H-4)), 3.60 (s, 2, Im(-CH2)), 3.57 (s, 4, AmIm(CH2)), 3.07 (s, 3, Im(-CH3)), 3.02 (s, 6, AmIm(-CH3)), 1.18 (s, 18, AmIm(-C(CH3)3)). 13C NMR delta 174.1, 169.7 (s, AmIm(-C=O)), 145.4 (s,Im(C2)), 141.2 (s, AmIm(C2)), 135.5 (s, AmIm(C4)), 126.4 (s,Im(C5)), 120.8 (s, Im(C4)), 107.9 (s, AmIm(C-5)), 47.8 (s, Im(-CH2-), AmIm(-CH2-)), 38.0 (s, AmIm(C(CH3)3), 31.1 (s, Im(CH3)), 28.9 (s, AmIm(C(CH3)3); HRMS calcd for C25H40N9O2, 498.3305 [M+H+], found 498.3311.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 124312-73-8.

Reference:
Article; Cheruzel, Lionel E.; Cui, Jinlan; Mashuta, Mark S.; Grapperhaus, Craig A.; Buchanan, Robert M.; Tetrahedron Letters; vol. 52; 37; (2011); p. 4771 – 4774;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

13-Sep-21 News New learning discoveries about 124312-73-8

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Application of 124312-73-8, A common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, molecular formula is C5H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of K2PtCl4 (0.208 g, 0.500 mmol) in 16 mL of H2O/HCl 4 M (ratio 15/1), the diamine (0.500 mmol) was added. The mixture was stirred for 6 h and heated under reflux, then it was warmed to room temperature and stirred overnight. The complex was filtered off and washed with water, methanol and diethyl ether. The solid was dried under vacuum at room temperature.

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ferri, Nicola; Cazzaniga, Stefano; Mazzarella, Luca; Curigliano, Giuseppe; Lucchini, Giorgio; Zerla, Daniele; Gandolfi, Raffaella; Facchetti, Giorgio; Pellizzoni, Michela; Rimoldi, Isabella; Bioorganic and Medicinal Chemistry; vol. 21; 8; (2013); p. 2379 – 2386;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The origin of a common compound about (1-Methyl-1H-imidazol-2-yl)methanamine

Statistics shows that (1-Methyl-1H-imidazol-2-yl)methanamine is playing an increasingly important role. we look forward to future research findings about 124312-73-8.

Synthetic Route of 124312-73-8, These common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Chloro-6-N-(7i-propyl)amino-[1,3,5]triazin-2-yl)-N,0-dimethyl- hydroxylamine (CD) (1 g, 4.5 mmol), (l-methyl-1H-imidazol-2-yl)methanamine (600 mg, 5.4 mmol) and KaC03 (1.24 g, 9 mmol) in EtOH (50 mL) were heated at 100 C for 16 h. The reaction mixture was filtered, and the volatiles were removed under reduced pressure. The residue was dissolved in EtOAc (100 mL), washed with water (30 mL) and then with a brine solution (30 mL), and lastly dried over Na2S0 . The solvent was removed under reduced pressure. The crude product was purified by flash column chromatography (DCM MeOH=20/l to 8/1) to yield 4-N-(l-N- methylimidazol^-y^-methylamino-e-N-in-pro y amino-tl.S^Itriazin^-yl^NjO- dimethyl-hydroxylamine (CVII, 650 mg, 47%).

Statistics shows that (1-Methyl-1H-imidazol-2-yl)methanamine is playing an increasingly important role. we look forward to future research findings about 124312-73-8.

Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott, L.; WOODWARD, Richard; PENG, Sean; WO2012/74999; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analyzing the synthesis route of (1-Methyl-1H-imidazol-2-yl)methanamine

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 124312-73-8.

New learning discoveries about 124312-73-8

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 124312-73-8, A common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, molecular formula is C5H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Continuously updated synthesis method about 124312-73-8

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Application of 124312-73-8, These common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 13 To a solution of ester (750 mg, 1.83 mmol), (1-methyl-1H-imidazol-2-yl)methanamine (0.50 mL, 4.50 mmol) and DBU (0.80 mL, 5.35 mmol) in DCM (50 mL) was added AlCl3 (750 mg, 5.62 mmol). The reaction mixture was stirred at rt for 3 h. The reaction was diluted with DCM (200 mL) and 3N NaOH (100 mL) and stirred for 10 min. The layers were separated and the organic layer was washed with H2O (2¡Á100 mL), brine (100 mL), and dried over Na2SO4. The solvent was removed under reduced pressure and the reaction crude was purified on silica column (0-5% MeOH/DCM) to yield the desired product as a white solid (275 mg, 32%). 1H NMR (CDCl3) delta: 11.0 (t, 1H), 9.45 (d, 1H), 8.61 (d, 1H), 7.76 (dd, 1H), 7.50 (m, 1H), 7.45 (m, 1H), 6.99 (d, 1H), 6.90 (d, 1H), 6.83 (d, 1H), 4.82 (d, 2H), 3.93 (t, 4H), 3.81 (t, 4H), 3.70 (s, 3H). LCMS (ES): m/z 475 [M+1]+.

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NAGASAWA, Johnny Yasuo; PIERRE, Fabrice; HADDACH, Mustapha; SCHWAEBE, Michael; DARJANIA, Levan; WHITTEN, Jeffrey P.; US2009/93455; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of 124312-73-8

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

General procedure: To a solution of 7-chloro-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine (1 equiv) and diisopropylethylamine (1.5 equiv) in 2-propanol was added amine (1.2 equiv). After refluxing for 16 h, the reaction mixture was concentrated in vacuo and the appropriate solvent added to precipitate the crude product, which was collected by filtration and then purified by recrystallization, prep HPLC or column chromatography.

The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Candice, Soares De Melo; Feng, Tzu-Shean; Van Der Westhuyzen, Renier; Gessner, Richard K.; Street, Leslie J.; Morgans, Garreth L.; Warner, Digby F.; Moosa, Atica; Naran, Krupa; Lawrence, Nina; Boshoff, Helena I.M.; Barry, Clifton E.; Harris, C. John; Gordon, Richard; Chibale, Kelly; Bioorganic and Medicinal Chemistry; vol. 23; 22; (2015); p. 7240 – 7250;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Share a compound : 124312-73-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1-Methyl-1H-imidazol-2-yl)methanamine, its application will become more common.

Reference of 124312-73-8,Some common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound (225 mg) obtained in Example 55-3 was dissolved in methanol (4.0 ml). The solution was added with the compound (64.5 mg) obtained in Example 14-7 and trimethyl orthoformate (0.13 ml) and the whole was stirred at room temperature for 1.5 hours. After having been cooled to 0C, the reaction solution was added with sodium borohydride (20.8 mg) and the whole was stirred at room temperature for 20 minutes. After the reaction solution was concentrated under reduced pressure, the resultant residue was added with distilled water and the whole was subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with an anhydrous sodium sulfate. The drying agent was filtrated out and then the organic layer was concentrated under reduced pressure. The resultant was dissolved in methanol (6.0 ml). The reaction solution was added with 2-imidazole carboxaldehyde (83.3 mg) and sodium cyanoborohydride (77.3 mg). The whole was added with acetic acid to adjust the pH to 5 and stirred at room temperature for 18 hours. The reaction solution was concentrated under reduced pressure. The resultant residue was added with a 1 mol/l sodium hydroxide aqueous solution and the whole was subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. The drying agent was filtrated out and then the organic layer was concentrated under reduced pressure. The resultant residue was purified through silica gel column chromatography (hexane/ethyl acetate) and treated with hydrochloric acid, thereby obtaining a hydrochloride (174.3 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=567[M+H]+ 1H-NMR(500MHz,DMSO-d6):delta=0.90(6H,t,J=7.3Hz),1.64-1.86(8H,m),2.95(4H,br),3.05(2H,br),3.28(2H,br),3.67(3H,s),3.83(2H,s),4.10(2H,s),4.17(2H,s),5.94(2H,s),7.31-7.39(5H,m),7.49-7.54(3H,m),7.60(2H,s),7.72(1H,d,J=8.4Hz),8.17(1H,s),10.43(1H,br),14.94(2H,br).

Reference:
Patent; Kureha Corporation; EP1724263; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem