Category: 1207457-15-5

Introduction of a new synthetic route about C8H11BrN2O2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-1H-imidazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 1207457-15-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1207457-15-5, name is tert-Butyl 2-bromo-1H-imidazole-1-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1. To a mixture of 1 (PCT Int. Appl. (2008), WO 2008079277 A, 4 g, 14 mmol) tert-butyl 2-bromo-lH-imidazole-l-carboxylate (FCH Group, 1.8 g, 7 mmol) and NaOH (3 mL,1.5 M) in toluene (20 mL) and ethanol (2 mL) was added Pd(PPh3)4 (0.084 g, 0.14 mmol) under N2. The resulting mixture was stirred at 120 C for 24 h. The mixture was cooled to RT, treated with water and extracted with EA. The combined organic extracts were washed with water, brine, dried over anhydrous Na2SC>4, filtered and concentrated to give a crude oil. The crude product was purified by recrystallization to afford 2 (1.1 g, 38 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-1H-imidazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; CHIANG, Lillian W.; MURPHY, Eain Anthony; KAYSER, Frank; SUN, Qun; FINK, Sarah Jocelyn; (128 pag.)WO2019/79519; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analyzing the synthesis route of 1207457-15-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-1H-imidazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1207457-15-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1207457-15-5, name is tert-Butyl 2-bromo-1H-imidazole-1-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 11 compound 8Peptide a (0.34 g, 0.00053 mol) , b (0.26 g, 0.0011 mol), tetrakis(triphenylphosphine)palladium(0) (0.031 g, 0.000026 mol) and sodium bicarbonate (0.22 g, 0.0026 mol) were suspended in dimethoxyethane and water in a 40 ml microwave vessel, degased and filled under an N2 atmosphere. The process was repeated 2x. Microwaved at 1500C for 20 min at which point the reaction was complete. LCMS showed desired product peak.The reaction mixture was diluted with CH2Cl2, washed with IN NaOH, extracted by CH2Cl2 2x, dried and concentrated. Purified by ISCO chromatography (4Og colunm, 0-50% EtOAc/Hexane). Intermediate c was reacted with TFA in methylenechloride for 30 mins and concentrated. LCMS showed 4 major peaks, DP peak at 1.32 min. The compound was dissolved in DMF, purified by prep HPLC (5%-30% 20 min, flow rate was reduced to 30 ml/min) and lyophilized to give 22 mg of compound 8 as a white loose powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-1H-imidazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; DUDLEY, Dannette; FLYGARE, John, A.; NDUBAKU, Chudi; WO2010/17035; (2010); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem