Category: 120118-14-1

Han, Shuaibing published the artcileResidue dissipation and dietary risk assessment of cyazofamid and its metabolite CCIM in garlic, garlic bolt and garlic sprout, Computed Properties of 120118-14-1, the publication is International Journal of Environmental Analytical Chemistry, database is CAplus.

The residue and dissipation dynamics of cyazofamid and its main metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM) in garlic, garlic bolt and garlic sprouts were investigated by QuEChERS high-performance liquid chromatog.-tandem mass spectrometry method. Field experiments were conducted in 6 sites for one year. The dietary intake risk of cyazofamid was assessed. At different levels, the results showed that the average recoveries of cyazofamid were 89.8%-1005% in garlic, 84.6%-109.4% in garlic bolt and 88.6%-108.5% in garlic sprout, recoveries of CCIM were 84.6%-104.2% in garlic, 84.6%-108.9% in garlic bolt and 85.3%-109.2% in garlic sprout, resp., with relative standard deviation less than 10.1%. The limits of quantitation were all 0.01 mg/kg. The dissipation dynamics of cyazofamid and CCIM in garlic plant matrixes fitted the first order kinetic equation, and the half-lives were 3.5-6.1 d and 0.9-3.9 d, resp. The dietary intake risk assessment showed that the dietary exposure risk index of cyazofamid in garlic, garlic bolt and garlic sprout were less than 100%, which indicated that the dietary exposure risk was at an acceptable level.

International Journal of Environmental Analytical Chemistry published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Computed Properties of 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Mei published the artcileDissipation and Risk Assessment of Multiresidual Fungicides in Grapes under Field Conditions, Product Details of C11H8ClN3, the publication is Journal of Agricultural and Food Chemistry (2020), 68(4), 1071-1078, database is CAplus and MEDLINE.

Grapes are among the most popular fruits globally, and various fungicides are widely applied to grape crops. As such, the presence of multiple fungicide residues and dietary risks in grapes has become the focus of significant attention. In this study, an easy-to-implement and sensitive UPLC-MS/MS approach was developed to simultaneously determine pyraclostrobin, dimethomorph, cymoxanil, cyazofamid and its metabolite CCIM in grapes via QuEChERS. This approach achieved 78.1-106.0% recovery and a 0.01 mg kg^-1 limit of quantitation (LOQ). Field trials revealed that these compounds had degradation half-lives ranging from 0.9 to 14.4 days. And their terminal residues ranging from < LOQ to 0.94 mg kg^-1 were below the official maximum residue limit (MRL) in China. The short-term risk for each tested fungicide was below 54%. The long-term risk of individual chems. ranged from 0.0086% to 2%, and their cumulative risk was 3.3%. Results indicated that the dietary risk of these fungicides in grapes was minor.

Journal of Agricultural and Food Chemistry published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C9H5ClO4S, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Qingxi published the artcileThe dissipation of cyazofamid and its main metabolite CCIM during tomato growth and tomato paste making process, Product Details of C11H8ClN3, the publication is Food Additives & Contaminants, Part A (2019), 36(9), 1327-1336, database is CAplus and MEDLINE.

In several studies focused on the residues of cyazofamid and its main metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM) on tomato where it is widely used, CCIM has been shown to have higher acute toxicity than cyazofamid, and this is crucial to evaluate the potential food risk of cyazofamid and CCIM. In this study, the dissipation of cyazofamid and CCIM during tomato growth and tomato paste making process were assessed. The targeted compounds cyazofamid and CCIM were determined by LC-MS/MS. The results indicated that the half-life of cyazofamid was 4.6 days after applying in the field, and the maximum value of CCIM was 0.08 mg/kg at 3 days after the last application of cyazofamid, then gradually decreased. In addition, the concentrations of cyazofamid and CCIM were affected by different processing steps including washing, peeling, homogenisation, simmering, and sterilisation. Results showed that the mean losses of cyazofamid and CCIM were 92.3% and 75.2% after washing and peeling. The Processing Factor (PF) values were all less than 1. Especially for peeling, the PFs of cyazofamid and CCIM were 0.12 and 0.04, resp.

Food Additives & Contaminants, Part A published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H9NO3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sarker, Aniruddha published the artcileResidue Monitoring and Risk Assessment of Cyazofamid and Its Metabolite in Korean Cabbage Under Greenhouse Conditions, Product Details of C11H8ClN3, the publication is Bulletin of Environmental Contamination and Toxicology (2020), 105(4), 595-601, database is CAplus and MEDLINE.

The residual characteristics and risk assessment with respect to cyazofamid and its metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile were monitored in case of Korean cabbage at different preharvest intervals during a greenhouse trial. The 0.02 kg a.i/ha of cyazofamid was sprayed twice on seven-day intervals (i.e., on day 0, 7, 14, and 21 before harvest). The liquid chromatog.-tandem mass spectrometry anal. was used to monitor the residual amount of fungicide. The matrix-matched calibration curves with respect to the cyazofamid in Korean cabbage exhibited good linearity (R2 �0.999) and acceptable recoveries of 84.1%-114.9%. The biol. half-life of cyazofamid in Korean cabbage was 3.18 days. During the treatment, the preharvest residue of cyazofamid in Korean cabbage 14 days before harvest (0.80 mg/kg) was lower than that specified by the MFDS-MRL (Ministry of Food and Drug Safety-Maximum Residue Limit, 2.0 mg/kg) and should be recommended as the safe preharvest-interval application limit. The hazard quotient showed low toxicity (70.58%) during the risk assessment study of cyazofamid.

Bulletin of Environmental Contamination and Toxicology published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Qian, Weirui published the artcileReceipt of several pesticide petitions filed for residues of pesticide chemicals in or on various commodities, Category: imidazoles-derivatives, the publication is Federal Register (2011), 76(236), 76674-76677, database is CAplus.

The Environmental Protection Agency’s receipt of several initial filings of pesticide petitions requesting the establishment or modification of regulations for residues of pesticide chems. in or on various commodities is announced.

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C5H5NO3S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Xinyu published the artcileCyazofamid; pesticide tolerances, Recommanded Product: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, the publication is Federal Register (2008), 73(79), 21834-21839, database is CAplus.

A tolerance of 0.09 ppm is established for combined residues of cyazofamid and its metabolite CCIM in or on carrot, roots. Interregional Research Project Number 4 (IR-4) requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H5F3N4, Recommanded Product: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Zhiyuan published the artcileCyazofamid; pesticide tolerances, COA of Formula: C11H8ClN3, the publication is Federal Register (2010), 75(134), 40745-40751, database is CAplus.

Tolerances are established for residues of cyazofamid in or on Brassica, head and stem, subgroup 5A; Brassica, leafy greens, subgroup 5B; turnip, greens; spinach; and hop, dried cones. Interregional Research Project Number 4 (IR-4) requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H13N5O, COA of Formula: C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Qun published the artcileCyazofamid; pesticide tolerance, Name: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, the publication is Federal Register (2004), 69(189), 58290-58299, database is CAplus.

A tolerance is established for the combined residues of cyazofamid and its metabolite CCIM in or on potatoes, tomatoes, cucurbits, and imported wine. ISK Biosciences Corporation requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C6H8O4, Name: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Qun published the artcileCyazofamid: pesticide tolerances, Product Details of C11H8ClN3, the publication is Federal Register (2012), 77(187), 59114-59120, database is CAplus.

Tolerances are established for residues of cyazofamid in or on basil, succulent beans, and vegetables. This regulation addnl. removes several established tolerances that are superseded by tolerances established by this regulation. Interregional Research Project Number 4 (IR-4) requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C25H16O, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Scrivener, Karen published the artcileCyazofamid; pesticide tolerance; technical correction, Related Products of imidazoles-derivatives, the publication is Federal Register (2004), 69(235), 70897-70898, database is CAplus.

EPA issued a final rule in the Federal Register of Sept. 30, 2004 establishing a tolerance for the combined residues of cyazofamid and its metabolite CCIM in or on potatoes, tomatoes, cucurbits, and imported wine. The signature and date are added. ISK Biosciences Corporation requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C13H10N2S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem