Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators was written by Bischoff, Francois;Berthelot, Didier;De Cleyn, Michel;MacDonald, Gregor;Minne, Garrett;Oehlrich, Daniel;Pieters, Serge;Surkyn, Michel;Trabanco, Andres A.;Tresadern, Gary;Van Brandt, Sven;Velter, Ingrid;Zaja, Mirko;Borghys, Herman;Masungi, Chantal;Mercken, Marc;Gijsen, Harrie J. M.. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 1194374-75-8 The following contents are mentioned in the article:
The design and the synthesis of several chem. subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of an aminopyridone into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo potency. This has resulted in the identification of benzimidazole I as a GSM with low nanomolar potency in vitro. In mouse, rat, and dog, this compound displayed the typical γ-secretase modulatory profile by lowering Aβ42 and Aβ40 levels combined with an especially pronounced increase in Aβ38 and Aβ37 levels while leaving the total levels of amyloid peptides unchanged. This study involved multiple reactions and reactants, such as 8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8Recommanded Product: 1194374-75-8).
8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1194374-75-8
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem