Category: 117976-90-6

Formulation and in vitro evaluation of rabeprazole sodium delayed release tablets was written by K., Bhavani;L., Matsyagiri. And the article was included in World Journal of Pharmaceutical Research in 2019.HPLC of Formula: 117976-90-6 The following contents are mentioned in the article:

The main objective of this research work was to formulate and evaluate the delayed release tablets of rabeprazole sodium, an anti ulcer drug like peptic ulcer and duodenal ulcer. Rabeprazole was classI proton pump inhibitor to gain FDA approval. Rabeprazole sodium delayed release tablets were prepared by direct compression technique and dry granulation method. All the Excipients are tested for compatibility with drug, which revealed that there was no phys. and chem. interaction occurred. During film coating Appearance, average weight, hardness, thickness, disintegration and during film coating appearance of film coating, Average weight of film coating tablet, disintegration time and during enteric coating appearance and average weight of enteric coated tablets acid resistance this parameters were performed like wt variation test, hardness, friability, disintegration time. Among all formulations, formulation F12 was found to be best of all the formulations showing drug release matching the innovator product so to that formulation all the quality control tests were done for conformation. Stability study is carried out for 3 mo at 25掳C; 60% RH: and 40掳C; 75% RH, according to ICH guidelines. The effect of these variables on drug release also studied. The in vitro drug release studied was performed in the disintegration apparatus This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6HPLC of Formula: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation of immediate release tablets of Rabeprazole sodium by using tablet in tablet technology was written by Firoz, Syed. Gouse;Amaragiri Lakshmi, N.;Vasantha Kumari, B.;Swapnamadhuri, P.;Sudha Rani, S.;Karthik, S.. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2021.HPLC of Formula: 117976-90-6 The following contents are mentioned in the article:

Rabeprazole provided effective control of gastric acid in patients with symptoms of gastroesophageal reflux. The present work was carried out to improve the therapeutic efficacy of Rabeprazole by expediting its onset of action. Rabeprazole is unstable in acidic environment which requires the drug in immediate release tablet to be delivered in an alk. environment to enhance the in vivo stability of Rabeprazole. The tablets were prepared by using Tablet-in-Tablet technol., in which the drug was present as inner core and the buffer as the outer layer. A total of four inner core formulations were prepared by direct compression method and evaluated for their phys. parameters. Outer core formulation was prepared using wet granulation method. A total of six tablets in tablet formulations were prepared using A4 as the best inner core formulation depending upon its disintegration time. The prepared tablets were film coated by using Insta moist shield film coating material, to protect the formulation from moisture absorbance. All the six formulations were evaluated and Batch F6 was selected as best formulation and compared with the reference product. The developed tablets were found to be superior to the existing immediate release formulations by providing macro pH environment instead of micro pH ambience with less buffer content. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6HPLC of Formula: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand based 3D-QSAR model, pharmacophore, molecular docking and ADME to identify potential fibroblast growth factor receptor 1 inhibitors was written by Huang, Lu;Wu, Xulong;Fu, Xiaoli;Wang, Haoxiang;Tang, Biao;Xiao, Yirong;Zhou, Caixia;Zhao, Zhiqiao;Wan, Yujun;Chen, Hui;Tang, Zizhong;Yao, Huipeng;Shan, Zhi;Bu, Tongliang. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Application of 117976-90-6 The following contents are mentioned in the article:

The FGF/FGFR system may affect tumor cells and stromal microenvironment through autocrine and paracrine stimulation, thereby significantly promoting oncogene transformation and tumor growth. Abnormal expression of FGFR1 in cells is considered to be the main cause of tumorigenesis and a potential target for the treatment of cancer. In this study, a combination of structure-based drug carriers and mol. docking-based virtual screening was used to screen new potential FGFR1 inhibitors. Forty eight known inhibitors were collected to establish 3 D-QSAR models and pharmacophore models, investigate the relationship between the activity and conformation of compounds, and verify the efficiency of pharmacophore. In Accelrys Discovery Studio 2016, the ZINC database was filtered by Lipinski鈥瞫 Rule of Five and SMART鈥瞫 filtration. Then, Hypo01 was used for virtual screening of ZINC database. Compounds with predicted activity values less than 1 渭M were molecularly docked with FGFR1 protein crystals, the docking results were observed, and the interaction between compounds and targets was studied. The absorption, distribution, metabolism and excretion (ADME) and toxicity of potential inhibitors were studied, and a compound with new structural scaffolds were obtained. It could be further studied to explore their better therapeutic effects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study was written by Kodama, Masaaki;Okimoto, Tadayoshi;Mizukami, Kazuhiro;Hirashita, Yuka;Wada, Yasuhiro;Fukuda, Masahide;Matsunari, Osamu;Okamoto, Kazuhisa;Ogawa, Ryo;Fukuda, Kensuke;Kudo, Yoko;Kawahara, Yoshinari;Murakami, Kazunari. And the article was included in Journal of Gastroenterology and Hepatology in 2021.Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate the effect of HPE, we observed the gastric mucosa for up to17 years after HPE and sex differences in gastric mucosa. In total, 172 patients (94 males, 78 females) with HPE were enrolled. Annual histol. evaluations were performed for up to 17 years. The grades of mononuclear cells, neutrophils, atrophy, IM in the antrum and corpus were evaluated using the updated Sydney system. Pre-HPE period, atrophy had improved significantly 1 yr after HPE in the antrum (1.50 卤 0.75 vs. 1.21 卤 1.25, P < 0.01) and corpus (0.59 卤 0.75 vs. 0.18 卤 0.52, P < 0.05). IM showed no significant change during 17 years after HPE at either biopsy site. Atrophy scores did not differ significantly between males and females. IM scores were significantly higher in males than in females before eradication (antrum, 0.67 卤 0.94 vs. 0.44 卤 0.77, P = 0.003, corpus, 0.20 卤 0.62 vs. 0.047 卤 0.21, P = 0.0027) and at most observation timepoints. During 17 years after HPE, atrophy, but not IM, improved significantly at the greater curvatures of the antrum and corpus. IM was significantly more severe in males than in females. Careful follow-up after HPE based on sex differences in gastric mucosal characteristics is important. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer was written by Matsuoka, Hiroya;Ando, Koji;Swayze, Emma J.;Unan, Elizabeth C.;Mathew, Joseph;Hu, Quingjiang;Tsuda, Yasuo;Nakashima, Yuichiro;Saeki, Hiroshi;Oki, Eiji;Bharti, Ajit K.;Mori, Masaki. And the article was included in PLoS One in 2020.Reference of 117976-90-6 The following contents are mentioned in the article:

Irinotecan specifically targets topoisomerase I (topoI), and is used to treat various solid tumors, but only 13-32% of patients respond to the therapy. Now, it is understood that the rapid rate of topoI degradation in response to irinotecan causes irinotecan resistance. We have published that the deregulated DNA-PKcs kinase cascade ensures rapid degradation of topoI and is at the core of the drug resistance mechanism of topoI inhibitors, including irinotecan. We also identified CTD small phosphatase 1 (CTDSP1) (a nuclear phosphatase) as a primary upstream regulator of DNA-PKcs in response to topoI inhibitors. Previous reports showed that rabeprazole, a proton pump inhibitor (PPI) inhibits CTDSP1 activity. The purpose of this study was to confirm the effects of rabeprazole on CTDSP1 activity and its impact on irinotecan-based therapy in colon cancer. Using differentially expressing CTDSP1 cells, we demonstrated that CTDSP1 contributes to the irinotecan sensitivity by preventing topoI degradation Retrospective anal. of patients receiving irinotecan with or without rabeprazole has shown the effects of CTDSP1 on irinotecan response. These results indicate that CTDSP1 promotes sensitivity to irinotecan and rabeprazole prevents this effect, resulting in drug resistance. To ensure the best chance at effective treatment, rabeprazole may not be a suitable PPI for cancer patients treated with irinotecan. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Reference of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rp-hplc method development and validation for simultaneous estimation of clidinium bromide, chlordiazepoxide, dicyclomine hcl and rabeprazole sodium in pharmaceutical dosage form was written by Khan, Ummekulsum;Luhar, Shailesh V.;Narkhede, Sachin B.. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2018.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:

A simple, rapid, economical, precise and accurate RP-HPLC method for simultaneous estimation of Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium has been developed. Method was studied by using Shimadzu 2010CHT, Chromatog. separation was achieved using ODS C18 RP column (250 mm 脳 4.6 mm i.d., 5渭m) kept at ambient temperature, using a mobile phase consisting a mixture of Phosphate buffer (pH 4.5): Acetonitrile (80:20 volume/volume) and pH adjusted with 0.5% orthophosphoric acid at a flow rate of 1.0 mL/min. The detection was made at 215 nm. Retention time was 3.12 min, 4.28 min and 6.97 min and 13.29 for Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium resp. Linear correlation was obtained between peak area and concentration in the range of 5-15 渭g/mL for Clidinium Bromide, 10-30 渭g/mL for Chlordiazepoxide, 20-60 渭g/mL for Dicyclomine HCl and Rabeprazole Sodium. The percentage recoveries of four drugs Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium were found to be 100.48-101.46 %, 98.87-101.75%,98.20-98.80% and 100.94-101.71 % resp. The % RSD value was less than 2, for intraday and interday precision. It can be successfully used for routine anal. of Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium in combined solid dosage form without any interference from common excipients and impurity. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proton Pump Inhibitors and Bone Health: An Update Narrative Review was written by Lespessailles, Eric;Toumi, Hechmi. And the article was included in International Journal of Molecular Sciences in 2022.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which controls acid production Introduced to the market in 1989, their use has increased rapidly worldwide and they are now among the top 10 most prescribed drugs in the United States. As of 2015, the FDA has already approved six drugs of this class (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole and rabeprazole). Recently, the risks and benefits of long-term PPI use were questioned and many studies indicated that their use should be carefully considered, especially in young patients, whose treatment with these drugs could last many years. Even greater concerns have been raised about a potential pos. association between PPIs and osteoporotic fracture risk including the hip, spine and wrist. Although based on observational studies, there is substantial evidence associating the long-term use of PPIs and fracture. This relationship is only partially admitted due to the lack of consistent effects of PPIs on bone mineral d. loss. Therefore, this narrative review aimed to discuss the recent findings pertaining to the risk of osteoporotic fracture associated with PPIs, in particular prolonged use, and to call for further research to elucidate the mechanisms associated with this bone fragility. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stereoselective pharmacokinetics of (R)-(+)- and (S)-(-)-rabeprazole in human using chiral LC-MS/MS after administration of rabeprazole sodium enteric-coated tablet was written by Sun, Lu-Ning;Shen, Yi-Wen;Ying, Yu-Wen;Li, Duo;Li, Teng-Fei;Zhang, Xue-Hui;Zhao, Ping;Ding, Li;Wang, Yong-Qing. And the article was included in Chirality in 2018.Recommanded Product: 117976-90-6 The following contents are mentioned in the article:

Rabeprazole is an effective proton pump inhibitor to treat acid-related diseases. To achieve the simultaneous determination of rabeprazole enantiomers in human plasma, a chiral LC-MS/MS method was developed and validated. Acetonitrile including 0.1% ammonium were used as protein precipitating agent. Analytes were separated within 8 min on a Chiralpak IC column (4.6 mm 脳 150 mm, 5 渭m). The mobile phase was 10 mM ammonium acetate including 0.2% acetic acid-acetonitrile (35:65, volume/volume). An API 4000 mass spectrometer was used as detector for the anal., and the multiple reactions monitoring transitions of m/z 360.1 鈫?242.2 and 346.1 鈫?198.1 were opted for quantifying rabeprazole enantiomers and internal standard Matrix effects were not apparent for each enantiomer and internal standard (esomeprazole), the calibration curves were linear over the concentration of 0.500 to 400 ng路mL^-1, the intra-run precisions were below 5.4%, the inter-run precisions were below 9.9%, and the accuracy was between -9.2% and 9.3%. There was no chiral inversion observed during sample storage, preparation procedure, and anal., demonstrating that analytes were stable in this study. This method was applied to the stereoselective pharmacokinetic study of (R)-(+)- and (S)-(-)-rabeprazole after oral administration of 10-mg rabeprazole sodium enteric-coated tablet in healthy Chinese subjects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fabrication of pH-Responsive Hydrogel and Its In Vitro and In Vivo Evaluation was written by Tulain, Ume Ruqia;Ahmad, Mahmood;Rashid, Ayesha;Malik, Muhammad Zubair;Iqbal, Furqan Muhammad. And the article was included in Advances in Polymer Technology in 2018.Related Products of 117976-90-6 The following contents are mentioned in the article:

The present research work deals with the development of pH-responsive hydrogel by free radical polymerization in aqueous media to protect the rabeprazole sodium from acidic environment of stomach. Swelling behavior of hydrogels that was observed in buffer of various pH indicated highly pH-dependent swelling of hydrogels. Characterization of pH-responsive hydrogels by FTIR, SEM, and thermal anal. revealed that hydrogel has porous structure, favors swelling, drug loading, and drug release at a specific site in gastrointestinal tract and thermally more stable than parent polymer. In comparison with simple drug solution and hydrogel formulations, pharmacokinetic parameters of hydrogels formulations showed a significant difference in C_max values of (CMC-g-AA) CA and the same oral dose of rabeprazole sodium was 87.28 卤 12.671 and 61.263 卤 5.37 ng/mL, resp., T_max of graft copolymer matrixes CA (4.43 h) was significantly (P < 0.05) higher than drug solution (1 h) and area under curves (AUCs) for CA (952.25 卤 191 ng路/mL) was significantly (P < 0.05) higher than the drug solution (83.67 卤 8.28 ng路/mL) indicated the effect of dosage form would last for longer duration. Thus, in vitro and in vivo drug release studies of hydrogels proved their controlled release behavior with preferential delivery into alk. pH environment and for a prolonged period of time. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Related Products of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioseparation and modelling study of six proton pump inhibitors on a novel 3, 5-dichloro-phenylcarbamated 尾-cyclodextrin chemically bonded chiral stationary phase by high performance liquid chromatography was written by Li, Meng;Jiang, Zhen;Guo, Xingjie;Di, Xin;Yu, Jia. And the article was included in Microchemical Journal in 2021.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

A fully substituted 尾-cyclodextrin derivative chem. bonded chiral stationary phase for high performance liquid chromatog., named MDCPC was prepared by linking 3, 5-dichloro-phenylcarbamated mono-6-ethylenediamine-尾-cyclodextrin to the surface of silica support. The as-prepared MDCPC was successfully characterized by SEM, fourier transform IR spectra, solid state NMR spectra, elemental anal. and thermogravimetric anal. The enantioselectivity of MDCPC was systematically evaluated by using proton pump inhibitors including omeprazole, lansoprazole, pantoprazole sodium, ilaprazole, rabeprazole sodium and tenatoprazole under the normal phase, polar organic phase, and reversed phase conditions. Effects of the mobile phase compositions and buffers on enantioseparation were investigated in different modes. As a result, MDCPC showed a better chromatog. performance in enantioselectivity, and all tested compounds were successfully enantiosepd. Findings of the mol. docking showed that hydrogen bonding, hydrophobic interaction and inclusion complexation played an important role in improving enantioselectivity. Addnl., good repeatability, column-to-column reproducibility and stability of MDCPC were observed by the study of chiral or achiral separation As a novel chiral stationary phase, MDCPC was supposed to be a promising prospect in the further anal. of chiral drugs. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem