Category: 117976-90-6

Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction was written by Chen, Wei-Lin;Li, Dong-Dong;Chen, Xin;Wang, Ying-Zhe;Xu, Jun-Jie;Jiang, Zheng-Yu;You, Qi-Dong;Guo, Xiao-Ke. And the article was included in European Journal of Medicinal Chemistry in 2020.Application of 117976-90-6 The following contents are mentioned in the article:

Genetic rearrangements of the mixed lineage leukemia (MLL) leading to oncogenic MLL-fusion proteins (MLL-FPs). MLL-FPs occur in about 10% of acute leukemias and are associated with dismal prognosis and treatment outcomes which emphasized the need for new therapeutic strategies. In present study, by a cell-based screening inhouse compound collection, we disclosed that Rabeprazole specially inhibited the proliferation of leukemia cells harboring MLL-FPs with little toxicity to non-MLL cells. Mechanism study showed Rabeprazole down-regulated the transcription of MLL-FPs related Hox and Meis1 genes and effectively inhibited MLL1 H3K4 methyltransferase (HMT) activity in MV4-11 cells bearing MLL-AF4 fusion protein. Displacement of MLL1 probe from WDR5 protein suggested that Rabeprazole may inhibit MLL1 HMT activity through disturbing MLL1-WDR5 protein-protein interaction. Moreover, other proton pump inhibitors (PPIs) also indicated the inhibition activity of MLL1-WDR5. Preliminary SARs showed the structural characteristics of PPIs were also essential for the activities of MLL1-WDR5 inhibition. Our results indicated the drug reposition of PPIs for MLL-rearranged leukemias and provided new insight for further optimization of targeting MLL1 methyltransferase activity, the MLL1-WDR5 interaction or WDR5. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence. was written by Mart铆nez-P茅rez, Yoalli;Nequiz-Avenda帽o, Mario;Garc铆a-Torres, Itzhel;Gudi帽o-Zayas, Marco E;L贸pez-Vel谩zquez, Gabriel;Enr铆quez-Flores, Sergio;Mendoza, Edith;Saavedra, Emma;P茅rez-Tamayo, Ruy;Le贸n-Avila, Gloria;Olivos-Garc铆a, Alfonso. And the article was included in Parasitology research in 2020.Computed Properties of C18H20N3NaO3S The following contents are mentioned in the article:

Amoebiasis is a human parasitic disease caused by Entamoeba histolytica. The parasite can invade the large intestine and other organs such as liver; resistance to the host tissue oxygen is a condition for parasite invasion and survival. Thioredoxin reductase of E. histolytica (EhTrxR) is a critical enzyme mainly involved in maintaining reduced the redox system and detoxifying the intracellular oxygen; therefore, it is necessary for E. histolytica survival under both aerobic in vitro and in vivo conditions. In the present work, it is reported that rabeprazole (Rb), a drug widely used to treat heartburn, was able to inhibit the EhTrxR recombinant enzyme. Moreover, Rb affected amoebic proliferation and several functions required for parasite virulence such as cytotoxicity, oxygen reduction to hydrogen peroxide, erythrophagocytosis, proteolysis, and oxygen and complement resistances. In addition, amoebic pre-incubation with sublethal Rb concentration (600聽渭M) promoted amoebic death during early liver infection in hamsters. Despite the high Rb concentration used to inhibit amoebic virulence, the wide E. histolytica pathogenic-related functions affected by Rb strongly suggest that its molecular structure can be used as scaffold to design new antiamoebic compounds with lower IC₅₀ values. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Computed Properties of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms was written by Watari, Shogo;Araki, Motoo;Matsumoto, Jun;Yoshinaga, Kasumi;Sekito, Takanori;Maruyama, Yuki;Mitsui, Yosuke;Sadahira, Takuya;Kubota, Risa;Nishimura, Shingo;Wada, Koichiro;Kobayashi, Yasuyuki;Takeuchi, Hidemi;Tanabe, Katsuyuki;Kitagawa, Masashi;Morinaga, Hiroshi;Kitamura, Shinji;Sugiyama, Hitoshi;Ariyoshi, Noritaka;Wada, Jun;Watanabe, Masami;Watanabe, Toyohiko;Nasu, Yasutomo. And the article was included in Drug Metabolism and Pharmacokinetics in 2021.Product Details of 117976-90-6 The following contents are mentioned in the article:

We evaluated the impact of vonoprazan on blood concentrations of tacrolimus via a retrospective anal. of 52 renal transplant recipients who took tacrolimus and converted from rabeprazole to vonoprazan between August 2018 and Sept. 2019. We compared tacrolimus trough levels upon conversion among groups that were classified based on cytochrome P 450 (CYP) gene polymorphisms. CYP3A5 groups were heterozygous or homozygous for CYP3A5*1 and CYP3A5*3 alleles. CYP2C19 genotypes were classified as extensive (*1/*1), intermediate (*1/*2 and *1/*3) or poor metabolizers (*2/*2, *2/*3 and *3/*3). Tacrolimus trough levels increased only 0.3 ng/mL upon conversion in the CYP3A5*3/*3 group: 5.8 [3.4-7.2] vs 6.1 [3.8-7.9]; p = 0.06. No statistically significance changes in tacrolimus levels also occurred in the CYP3A5*1/*1 or CYP3A5*1/*3 groups. Subgroup analyses of CYP3A5*3/*3 demonstrated low changes for all three CYP2C19 subgroups: 5.2 [4.3-6.5] vs 6.2 [4.3-7.9]; p = 0.07, 6.1 [3.4-7.2] vs 6.7 [4.6-7.9]; p = 0.12 and 5.4 [3.6-6.5] vs 4.7 [3.8-6.3]; p = 1.00, resp. Conversion to vonoprazan thus resulted in little increase of tacrolimus trough levels, even in the group predicted to be most susceptible (CYP3A5*3/*3 and 2C19*1/*1), thus supporting the safety of concomitant use of vonoprazan with tacrolimus. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Product Details of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of quadruple therapy on Hp eradication rate and gastrin level in patients with Helicobacter pylori-positive chronic superficial gastritis was written by Yan, Jin-he. And the article was included in Xiandai Zhenduan Yu Zhiliao in 2021.Application of 117976-90-6 The following contents are mentioned in the article:

Objective: To investigate the effect of quadruple therapy on Hp eradication rate and gastrin (GAS) level in patients with Helicobacter pylori (Hp) pos. chronic superficial gastritis. Methods: A total of 74 patients with Hp-pos. chronic superficial gastritis admitted to our hospital from August 2018 to Oct. 2019 were selected and divided into the control group and the observation group with 37 cases in each group according to the random number table method. The observation group was treated with rabeprazole sodium quadruple therapy, and the control group was treated with omeprazole quadruple therapy. After 6 wk of treatment, the Hp eradication rates, GAS levels and adverse reactions were compared between the two groups. Results: The eradication rate of Hp in the observation group was higher than that in the control group (P < 0.05). After 6 wk of treatment, the GAS levels in both groups were lower than those before treatment, and the observation group was significantly lower than the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion: Rabeprazole sodium quadruple therapy can improve Hp eradication rate and GAS level in Hp-pos. chronic superficial gastritis patients with good safety. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prazoles targeting Tsg101 inhibit release of epstein-barr virus following reactivation from latency was written by Mannemuddhu, Sai Sudha;Xu, Huanzhou;Bleck, Christopher K. E.;Tjandra, Nico;Carter, Carol;Bhaduri-McIntosh, Sumita. And the article was included in Journal of Virology in 2021.Name: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus responsible for several diseases, including cancers of lymphoid and epithelial cells. EBV cancers typically exhibit viral latency; however, the production and release of EBV through its lytic phase are essential for cancer development. Antiviral agents that specifically target EBV production do not currently exist. Previously, we reported that the proton pump inhibitor tenatoprazole, which blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV. Here, we show that three structurally distinct prazoles impair mature particle formation postreactivation and identify the impact on stages of replication. The prazoles did not impair expression of lytic genes representative of the different kinetic classes but interfered with capsid maturation in the nucleus as well as virion transport from the nucleus. Replacement of endogenous Tsg101 with a mutant Tsg101 refractory to prazole-mediated inhibition rescued EBV release. These findings directly implicate Tsg101 in EBV nuclear egress and identify prazoles as potential therapeutic candidates for conditions that rely on EBV replication, such as chronic active EBV infection and posttransplant lymphoproliferative disorders. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Name: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An analysis of the biopharmaceutical behaviour of proton pump inhibitors with different physicochemical properties was written by Jiang, Xindong;Shen, Tianxiang;Jin, Zhaolei;Li, Chunlong;Li, Qingpo;Qiu, Weigen;Cui, Yannan;Han, Zhihui;Hou, Xuemei;You, Jian. And the article was included in Life Sciences in 2021.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:

At present, little information on the biopharmaceutical behavior of proton pump inhibitors (PPIs) describing their absorption and biodistribution in vivo has been reported because the extreme instability of PPIs in the gastrointestinal environment makes it difficult to analyze such behavior. In this work, a modified rat in situ intestinal perfusion model was employed to investigate absorption in the gastrointestinal tract and subsequent biodistribution of several PPIs (ilaprazole, esomeprazole and rabeprazole), which have different physicochem. properties. Our data indicated that PPIs exhibited significantly enhanced absorption rates in the whole intestine, including the duodenum, jejunum, ileum and colon, corresponding to the increase in the oil-water partition coefficient (LogP). PPIs and corresponding salt types showed no obvious differences in absorption, implying that solubility changes in the PPI have little effect on its absorption in the gastrointestinal tract. Among these PPIs, ilaprazole presented a more stable intestinal absorption behavior, as well as more distribution and longer residence time in the stomach by HPLC-MS/MS anal. and radioactivity counts after 14C radiolabelling. These results may be useful information for PPI optimization and oral formulation design. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clinical characteristics of hospitalized patients with drug-induced acute kidney injury and associated risk factors: a case-control study was written by Yu, Chengxuan;Guo, Daihong;Yao, Chong;Yang, Hongyi;Liu, Siyuan;Zhu, Yu;Kong, Xianghao. And the article was included in BioMed Research International in 2020.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clin. characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alc. abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). The occurrence of D-AKI in hospitalized patients had significant associations with alc. abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impact of rabeprazole sodium on pharmacokinetics of nimesulide in healthy volunteers: a prospective study from Pakistan was written by Munir, Iqra;Aslam, Bilal;Naseer, Rana Dawood;Mahmood, Asif;Saleem, Uzma;Sultana, Aisha;Muneer, Saiqa;Abrar, Muhammad Asad;Ashraf, Mudassar. And the article was included in Acta Poloniae Pharmaceutica in 2018.COA of Formula: C18H20N3NaO3S The following contents are mentioned in the article:

Nimesulide is mostly being prescribed along proton pump inhibitors such as rabeprazole sodium to reduce gastric irritation and damage. Therefore, present study was aimed to evaluate the effect of rabeprazole sodium on the pharmacokinetics of nimesulide in healthy adult male volunteers. Healthy volunteers (n = 30) participated in this study. After overnight fasting, blood samples (5 mL) were withdrawn at predetermined time intervals i.e. 0, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 h. After washout period of 15 days, Nimesulide was co-administered with rabeprazole sodium to the same volunteers and blood samples were taken again. Plasma concentration of nimesulide was determined by using HPLC technique. Pharmacokinetic parameters were determined by using pharmacokinetic software APO, MW/PHRAM version 3.02. Results showed that rabeprazole sodium increased the Cmax of nimesulide from 1.21 卤 0.27 mg/L to 1.79 卤 0.18 mg/L and AUC was increased from 12.96 卤 1.34 mg/L.h to 17.46 卤 1.54 mg/L.h. Clearance and Vd of nimesulide were decreased. Elevated plasma levels of nimsulide were observed due to enzymic inhibition effect of rabeprazole sodium. Impact of nimsulide on pharmacokinetics of rabeprazole was successfully determined The knowledge regarding drug – drug interaction would be beneficial for the researchers, health care professionals and patients. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6COA of Formula: C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvent-dependent carbon dots for multifunctional sensing of temperature, pH, and proton pump inhibitors was written by Chen, Piao;Peng, Jingdong;Zhang, Zilong;Wang, Xiang;Zhu, Xiaolan;Fan, Kun;Luo, Pan. And the article was included in Analytica Chimica Acta in 2022.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Multifunctional sensing, a strategy to improve the efficiency of anal. and detection, has attracted much attention. In this study, a multifunction sensing platform was developed for temperature, pH, and proton pump inhibitors (PPI) with fluorescence carbon dots. Solvent-dependent carbon dots (PG-CDs) were synthesized through a one-step solvothermal method from phloroglucinol with the assistance of HCl. Base on the effect of functional groups on the surface, solvent-dependent behavior, temperature and pH responsive fluorescence can be observed The PG-CDs display a reversible temperature-sensitive fluorescent behavior within 15-65 掳C in N, N-dimethylacetamide. The fluorescence intensity of PG-CDs also responded to pH in a range of 3.0-7.0 with good reversibility and anti-interference. Therefore, the platform for temperature and pH sensing was proposed. In addition, since the synergistic effect of dynamic and static quenching, proton pump inhibitors (PPI) can be detected sensitively, including esomeprazole (EPZ), omeprazole (OPZ), and rabeprazole (RPZ). The linear range of detection for EPZ, OPZ, and RPZ is 2.0-80.0, 2.0-75.0, and 10.0-200.0 渭M and the limits of detection is 0.29, 0.55, and 2.99 渭M, sep. The recoveries for real samples were between 91.83 and 102.3%, which indicated that the platform for PPI sensing had good accuracy. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography was written by Raja, Rupak;Alam, Syed Dilshad;Srisath, Vikas;Jain, Arvind Kumar;ALOthman, Zeid A.;Mohammed, Abdallah A. A.;Islam, Mohammad Ataul;Bhatt, Tahir;Ali, Imran. And the article was included in Journal of Separation Science in 2022.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatog. and high-performance liquid chromatog. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatog. was carbon dioxide-0.2% triethylamine in methanol (60:40) and 0.1% triethylamine in n-hexane-ethanol (50:50) in high-performance liquid chromatog. For supercritical fluid chromatog., values of the retention factor of pantoprazole enantiomers were 3.97 and 4.88. These values for rabeprazole enantiomers were 6.10 and 7.52. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.23 and 1.23 and 2.20 and 3.36, resp. Similarly, for high-performance liquid chromatog., the values of retention factor for enantiomers of pantoprazole were 4.02 and 7.32. These values for rabeprazole enantiomers were 5.32 and 7.88, resp. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.82 and 1.48 and 9.22 and 6.58, resp. A comparison was carried out, which confirmed supercritical fluid chromatog. as the best method due to its fastness, eco-friendly, and inexpensiveness. The reported methods are effective, efficient, and reproducible and may be used to sep. and identify pantoprazole and rabeprazole in any unknown samples. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem