Category: 1179361-84-2

Some common heterocyclic compound, 1179361-84-2, name is Ethyl 1-amino-1H-imidazole-5-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Ethyl 1-amino-1H-imidazole-5-carboxylate

Preparation of intermediate II-29; A mixture of intermediate II-30 and NH4CI in 7N NHa/MeOH solution was heated at 90C (sand bath) in a closed vessel for 72h. The reaction was heated at 110C for 24 h. Fresh 7N was added (20 mL) and the reaction was heated at 120C for 5 h. Solvents were evaporated to dryness. The residue was partitioned between EtOAc/water. The organic layer was washed once with water, dried and evaporated to give only 11 mg of residue. The aqueous layer was evaporated to dryness to give 400 mg of a white solid, as a mixture of desired product, intermediate 11-29 and NH4CI salts (yield > 100%) that was used as such in next reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1179361-84-2, its application will become more common.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco, Javier; WO2011/89400; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1179361-84-2 as follows. Formula: C6H9N3O2

Synthesis of Compound 8.2. Into a 100-mL sealed tube, was placed 8.1 (475 mg, 3.06 mmol, 1.00 equiv), ammonia in methanol (50 mL). The resulting solution was stirred for 48 h at 70 C. The resulting mixture was concentrated in vacuo. This resulted in 350 mg (91%) of l-amino-lH-imidazole-5-carboxamide (8.2) as an off-white solid.

According to the analysis of related databases, 1179361-84-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; (102 pag.)WO2017/4134; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem