Electric Literature of 116989-51-6,Some common heterocyclic compound, 116989-51-6, name is 2-(2-Nitro-1H-imidazol-1-yl)ethanamine hydrochloride, molecular formula is C5H9ClN4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of N1-[2-(2-nitro-1H-1-imidazolyl)ethyl]-3-iodobenzamide Into a solution of 2-(2-nitro-1H-1-imidazolyl)-1-ethylamine hydrochloride (23.3 mg) in dimethylformamide (5 mL), triethylamine (50.3 muL) and a solution of 2,5-dioxotetrahydro-1H-1-pyrrolyl-3-iodobenzoate (50 mg) in dimethylformamide (1 mL) were added, followed by stirring at room temperature overnight. After distilling off the solvent, dichloromethane was added to the residue, followed by washing with water. The resulting organic layer was dried over anhydrous sodium sulfate and after that the solvent was distilled off. The resulting residue was then dissolved in dichloromethane and impurities were filtered off to give the title compound (21.8 mg). 1H-NMR (400 MHz, DMSO-d6) delta: 3.66-3.70 (2H, m), 4.54-4.57 (2H, t, J=6.3), 7.12 (1H, t, J=0.98 Hz), 7.24-7.28 (1H, t, J=7.8 Hz), 7.52 (1H, s), 7.71-7.73 (1H, m), 7.86-7.89 (1H, m) 8.04 (1H, d). ESI-MS (m/z): 387 (M-H+)
The synthetic route of 116989-51-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUJIFILM RI PHARMA CO., LTD.; US2012/219500; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem