Category: 116343-89-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116343-89-6, name is Methyl 1-phenyl-1H-imidazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 1-phenyl-1H-imidazole-4-carboxylate

Step 3 Synthesis of 1-Phenyl-1H-imidazole-4-carboxylic acid To a stirred solution of 1-phenyl-1H-imidazole-4-carboxylic acid methyl ester (200 mg, 0.98 mmol) in a mixture of THF (3 mL), MeOH (3 mL), H2O (2 mL) was added, LiOH.H2O (249 mg, 5.9 mmol) and stirring was continued at ambient temperature for 2 hr. The reaction mixture was concentrated under reduced pressure. Cold water was then added to the residue which was then acidified with 10% aqueous HCl. The product was extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 105 mg (56%) of 1-phenyl-1H-imidazole-4-carboxylic acid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 116343-89-6.

Reference:
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

116343-89-6, name is Methyl 1-phenyl-1H-imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Methyl 1-phenyl-1H-imidazole-4-carboxylate

LiOH.H2O (143 mg, 3.4 mmol) was added to a stirred solution of 1-phenyl-1H-imidazole-4-carboxylic acid methyl ester (231 mg, 1.1 mmol) in a mixture of THF (3 mL), MeOH (1 mL), H2O (1 mL) and stirring was continued at ambient temperature for 3 hrs. The reaction mixture was concentrated under reduced pressure. Cold water was then added and acidified it with 10% aqueous HCl, the solid was collected to afford 180 mg (83.7% Yield) of 1-phenyl-1H-imidazole-4-carboxylic acid.

The synthetic route of 116343-89-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Forest Laboratories Holdings Limited; US2009/239810; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 116343-89-6, name is Methyl 1-phenyl-1H-imidazole-4-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 1-phenyl-1H-imidazole-4-carboxylate

To a stirred solution of methyl 1-phenyl-1H-imidazole-4-carboxylate (0.450 g, 2.23 mmol) in THF:water (9:1; 10 ml) was portion wise added NaOH (0.267 g, 6.68 mmol) at 0C. The reactionmixture was stirred at rt for 16 h. The resulting mixture was diluted with ice cold water (60 ml) and acidified using 1 M HC1 solution. The resulting mixture was extracted with EtOAc (3 x 60 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure yielding 1-phenyl-1H-imidazole-4-carboxylic acid (0.230 g, 1.22 mmol). This material was directly used in the next step withoutfurther purification. LCMS: Method C, 1.357 mi MS: ES+ 189.20.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; KEMP, Mark Ian; STOCKLEY, Martin Lee; MADIN, Andrew; (95 pag.)WO2017/103614; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem