The important role of C5H2N4

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1122-28-7, name is 4,5-Dicyanoimidazole, A new synthetic method of this compound is introduced below., Safety of 4,5-Dicyanoimidazole

Example 19 2-Bromo-4,5-dicyanoimidazole (21) STR70 To 1.18 g (10 mmol) 4,5-dicyanoimidazole and 25 ml 0.1 M NaOH was added 1.8 ml Br2 (35 mmol). The mixture was stirred overnight at room temperature and then acidified with dilute HCl. The solid was filtered, rinsed with water and recrystallized from water to give 1.5 g of dicyanobromoimidazole 21 (yield 76.4%).: m.p. 147-149 C. (lit. 141-143 C.); Rf=0.65 (ethyl acetate_methanol=4:1); MS(EI): 198([M+2], 96%), 196 ([M+ ], 100%), 171 (28.5), 169 (29.2), 117 (27.4), 91 (19.0), 64 (20.6), 53 (22.4), 38 (18.8).

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Isis Pharmaceuticals, Inc.; McGill University; US6160109; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extended knowledge of 1122-28-7

The chemical industry reduces the impact on the environment during synthesis 4,5-Dicyanoimidazole. I believe this compound will play a more active role in future production and life.

Related Products of 1122-28-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1122-28-7, name is 4,5-Dicyanoimidazole, This compound has unique chemical properties. The synthetic route is as follows.

Example 34 16-(4,5-Bis(5-tetrazolyl)imidazol-1 -yl)hexadecanoic acidA mixture of 16-bromohexadecanoic acid methyl ester (3.50 g, 10.02 mmol), 4,5- dicyanoimidazole (1.52 g, 12.87 mmol), MeCN (30 ml), and K2CO3 (1.95 g, 14.1 mmol) was stirred at 80 0C for 66 h. Water (100 ml) and 1 N HCI (40 ml) were added, and the product was extracted twice with AcOEt. The combined extracts were washed with brine, dried over MgSO4, and concentrated under reduced pressure. Recrystallization from MeOH (10 ml) yielded 3.41 g (88%) of 16-(4,5-dicyanoimidazol-1 -yl)hexadecanoic acid methyl ester as a colorless solid.

The chemical industry reduces the impact on the environment during synthesis 4,5-Dicyanoimidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVO NORDISK A/S; WO2006/5667; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The origin of a common compound about 1122-28-7

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1122-28-7, name is 4,5-Dicyanoimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H2N4

Example 19 2-Bromo-4,5-dicyanoimidazole (21) STR67 To 1.18 g (10 mmol) 4,5-dicyanoimidazole and 25 ml 0.1M NaOH was added 1.8 ml Br2 (35 mmol). The mixture was stirred overnight at room temperature and then acidified with dilute HCl. The solid was filtered, rinsed with water and recrystallized from water to give 1.5 g of dicyanobromoimidazole 21 (yield 76.4%).: m.p. 147-149 C. (lit. 141-143 C.); Rf=0.65 (ethyl acetate_methanol=4:1); MS(EI): 198([M+2], 96%), 196 (?M+!, 100%),171 (28.5), 169 (29.2), 117 (27.4), 91 (19.0), 64 (20.6), 53 (22.4), 38 (18.8).

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; McGill University; US5734041; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sources of common compounds: 1122-28-7

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1122-28-7, name is 4,5-Dicyanoimidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4,5-Dicyanoimidazole

EXAMPLE 42 1-Propylphthalimido-4,5-dicyanoimidazole A solution of 4,5-dicyanoimidazole (24.8 g, 0.2 mol) in DMF (500 mL) was treated with NaH (60%, 8.0 g, 0.2 mol) with the temperature maintained below 40 C. The reaction mixture was then stirred at 35 C. for 1 hour. N-(3-bromopropyl)-phthalimide (53.6 g, 0.2 mol) was added and the reaction mixture was stirred for 48 hours at 40 C. The reaction mixture was concentrated in vacuo to a gum and crystallized from EtOAC to give the title compound 33 g (54%) (mp 134-135 C.). 1 H NMR (DMSO) delta 2.21 (m, 2H, CH2), 3.61 (m, 2H, CH2), 4.30 (m, 2H, CH2), 7.88 (m, 4H, ArH), 8.36 (s, 1H, ArH).

The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Isis Pharmaceuticals, Inc.; US6107482; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some scientific research about 1122-28-7

According to the analysis of related databases, 1122-28-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1122-28-7 as follows. name: 4,5-Dicyanoimidazole

Example 19 2-Bromo-4,5-dicyanoimidazole (21) To 1.18 g (10 mmol) 4,5-dicyanoimidazole and 25 ml 0.1 M NaOH was added 1.8 ml Br2 (35 mmol). The mixture was stirred overnight at room temperature and then acidified with dilute HCl. The solid was filtered, rinsed with water and recrystallized from water to give 1.5 g of dicyanobromoimidazole 21 (yield 76.4%).: m.p. 147-149 C.(lit. 141-143 C.); Rf=0.65 (ethyl acetate_methanol=4:1); MS(EI): 198([M+2], 96%), 196 ([M+], 100%),171 (28.5), 169 (29.2), 117 (27.4), 91 (19.0), 64 (20.6), 53 (22.4), 38 (18.8).

According to the analysis of related databases, 1122-28-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; McGill University; US6476216; (2002); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem