Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1122-28-7, name is 4,5-Dicyanoimidazole, A new synthetic method of this compound is introduced below., Safety of 4,5-Dicyanoimidazole
Example 19 2-Bromo-4,5-dicyanoimidazole (21) STR70 To 1.18 g (10 mmol) 4,5-dicyanoimidazole and 25 ml 0.1 M NaOH was added 1.8 ml Br2 (35 mmol). The mixture was stirred overnight at room temperature and then acidified with dilute HCl. The solid was filtered, rinsed with water and recrystallized from water to give 1.5 g of dicyanobromoimidazole 21 (yield 76.4%).: m.p. 147-149 C. (lit. 141-143 C.); Rf=0.65 (ethyl acetate_methanol=4:1); MS(EI): 198([M+2], 96%), 196 ([M+ ], 100%), 171 (28.5), 169 (29.2), 117 (27.4), 91 (19.0), 64 (20.6), 53 (22.4), 38 (18.8).
The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Isis Pharmaceuticals, Inc.; McGill University; US6160109; (2000); A;,
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