Category: 1116-98-9

SDS of cas: 1116-98-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes. Author is Cheng, Yi; Zhang, Runmei; Lu, Tianhao; Shen, Yong; Wang, Min; Xie, Chunsong.

Under mild conditions, C3-quaternary 2H-pyrrolines I [R = H, 5-OMe, 5-Cl, etc.; R1 = Me, t-Bu; R2 = H, Me, Ph; R3 = Et, t-Bu] were convergently and efficiently assembled by Cu(II) and weak bases co-catalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and isocyanoacetates. Various functionalities were tolerated, affording 2H-pyrrolines with up to two quaternary centers in a single step.

Different reactions of this compound(tert-Butyl 2-cyanoacetate)SDS of cas: 1116-98-9 require different conditions, so the reaction conditions are very important.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1116-98-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent. Author is Wu, Nannan; Lian, Guangyu; Sheng, Jingyi; Wu, Dan; Yu, Xiyong; Lan, Huiyao; Hu, Wenhui; Yang, Zhongjin.

Targeting the SMAD3 protein is an attractive therapeutic strategy for treating cancer, as it avoids the potential toxicities due to targeting the TGF-β signaling pathway upstream. Compound SIS3 was the first selective SMAD3 inhibitor developed that had acceptable activity, but its poor water solubility limited its development. Here, a series of SIS3 analogs was created to investigate the structure-activity relationship for inhibiting the activation of SMAD3. On the basis of this SAR, further optimization generated a water-soluble compound, 16d, which was capable of effectively blocking SMAD3 activation in vitro and had similar NK cell-mediated anticancer effects in vivo to its parent SIS3. This study not only provided a preferable lead compound, 16d, for further drug discovery or a potential tool to study SMAD3 biol., but also proved the effectiveness of our strategy for water-solubility driven optimization.

The article 《Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent》 also mentions many details about this compound(1116-98-9)Related Products of 1116-98-9, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]) to get more information.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and styrene copolymerization of novel alkoxy ring-substituted tert-butyl phenylcyanoacrylates, published in 2021, which mentions a compound: 1116-98-9, mainly applied to styrene copolymerization alkoxy phenylcyanoacrylate, Computed Properties of C7H11NO2.

Novel alkoxy ring-substituted tert-Bu phenylcyanoacrylates, RPhCH=C(CN)CO2C(CH3)3 (where R is 2-methoxy, 3-methoxy, 4-methoxy, 2-ethoxy, 3-ethoxy, 4-ethoxy, 4-propoxy, 4-butoxy) were prepared and copolymerized with styrene. The acrylates were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and tert-Bu cyanoacetate, and characterized by CHN anal., IR, 1H and 13C NMR. All the acrylates were radically copolymerized with styrene in solution at 70°C. The compositions of the copolymers were calculated from nitrogen anal.

The article 《Synthesis and styrene copolymerization of novel alkoxy ring-substituted tert-butyl phenylcyanoacrylates》 also mentions many details about this compound(1116-98-9)Computed Properties of C7H11NO2, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Trost, Barry M.; Jiao, Zhiwei; Liu, Ying; Min, Chang; Hung, Chao-I. Joey researched the compound: tert-Butyl 2-cyanoacetate( cas:1116-98-9 ).Name: tert-Butyl 2-cyanoacetate.They published the article 《Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes》 about this compound( cas:1116-98-9 ) in Journal of the American Chemical Society. Keywords: palladium catalyzed enantioselective cycloaddition aliphatic dipole; chiral cyclohexne spiro heptane synthesis. We’ll tell you more about this compound (cas:1116-98-9).

Design and exploration of new intermediates for chemo-, regio-, and stereoselective cycloadditions remain a formidable challenge in modern organic synthesis. Compared to the well-developed 1,3-dipolar cycloadditions, Pd-catalyzed 1,4-dipolar cycloadditions are generally limited to specialized substrates due to the inherent nature of the thermodynamically driven intramol. transformations and undesired isomerizations. Herein, we demonstrate the use of ligated palladium catalysts to control and modulate the intermol. reactivity of aliphatic 1,4-dipoles, enabling two distinctive cycloaddition pathways with a broad scope of acceptors. This atom-economic process also features an eco-friendly in situ deprotonation strategy to generate the corresponding active palladium-mediated dipoles. Overall, a diverse array of chiral 6-membered rings and spiro [2.4] heptanes were prepared in high yield and selectivity. In addition, an unexpected property of cyano-stabilized carbanions was discovered and investigated, which can be useful in designing and predicting future transformations.

The article 《Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes》 also mentions many details about this compound(1116-98-9)Name: tert-Butyl 2-cyanoacetate, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Molecular engineering of metal-free organic sensitizers with polycyclic benzenoid hydrocarbon donor for DSSC applications: The effect of the conjugate mode.Recommanded Product: 1116-98-9.

Optimizing the mol. structure to adjust the properties of photosensitizer is one of the crucial means to improve the power conversion efficiency of dye-sensitized solar cells (DSSCs). In this paper, four aromatic fused rings were selected as electron donor units to construct photosensitizers PBT-series. The effects of structural differences in the donor moiety on the photophys. and photochem. properties of the mols. were investigated in detail. The results show that the devices based on the dyes with triphenylene or fluoranthene as electron donor can yield higher short-circuit photocurrent densities (Jsc) and open-circuit voltages (Voc) than the devices based on the reference dyes with pyrene or phenanthrene as electron donor, and the power conversion efficiency (PCE) is increased by 37% and 23%, resp. PBT-2 and PBT-4 sensitizers have better light absorption properties due to stronger intramol. charge transfer (ICT) charge transitions, which helps to increase the photocurrent of devices, while they also exhibit significantly lower charge recombination rates. Eventually, PBT-2-based devices showed the best power conversion efficiency of 7.67% under the standard global AM 1.5 solar conditions.

The article 《Molecular engineering of metal-free organic sensitizers with polycyclic benzenoid hydrocarbon donor for DSSC applications: The effect of the conjugate mode》 also mentions many details about this compound(1116-98-9)Recommanded Product: 1116-98-9, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of novel sensitizers with a linear conjugated di(1-benzothieno)[3,2-b:2′,3′-d]pyrrole unit for dye-sensitized solar cells, published in 2019-03-31, which mentions a compound: 1116-98-9, mainly applied to dye sensitized solar cell, Quality Control of tert-Butyl 2-cyanoacetate.

Three novel D-π-A structural metal-free organic sensitizers (DBTP-1∼3) are designed, in which a linear planar aromatic group, the di(1-benzothieno)[3,2-b:2′,3′-d]pyrrole is first introduced as the π-bridge for dye-sensitized solar cells. Triphenylamine, 9,9-dimethyle-9H-fluorene and carbazole serve as the electron donor, resp., while cyanoacrylic acid is used as an electron acceptor and anchoring unit. The photophys., electrochem., theor. calculations have been employed to apprehend the correlation between the structures of DBTP-1∼3 and their photovoltaic performances. Further, co-adsorption studies are used to investigate the electronic recombination of the target dyes. As a result, the maximum power conversion efficiency of 6.50% (short-circuit current of 14.66 mA cm-2, open-circuit voltage of 0.67 V, and fill factor of 66%) for the 2 mM chenodeoxycholic acid co-adsorbed device based on DBTP-1 is obtained, while without any co-adsorbent it gives efficiency of 4.55%. The standard dye N719 gives 8.54% power conversion efficiency.

After consulting a lot of data, we found that this compound(1116-98-9)Quality Control of tert-Butyl 2-cyanoacetate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formula: C7H11NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers.

A widely applicable, practical, and scalable strategy for efficient and enantioselective synthesis of β,γ-unsaturated ketones that contain an α-stereogenic center is disclosed. Accordingly, aryl, heteroaryl, alkynyl, alkenyl, allyl, or alkyl ketones that contain an α-stereogenic carbon with an alkyl, an aryl, a benzyloxy, or a siloxy moiety can be generated from readily available starting materials and by the use of com. available chiral ligands in 52-96% yield and 93:7 to >99:1 enantiomeric ratio. To develop the new method, conditions were identified so that high enantioselectivity would be attained and the resulting α-substituted NH-ketimines, wherein there is strong C=N → B(pin) coordination, would not epimerize before conversion to the derived ketone by hydrolysis. It is demonstrated that the ketone products can be converted to an assortment of homoallylic tertiary alcs. in 70-96% yield and 92:8 to >98:2 dr-in either diastereomeric form-by reactions with alkyl-, aryl-, heteroaryl-, allyl-, vinyl-, alkynyl-, or propargyl-metal reagents. The utility of the approach is highlighted through transformations that furnish other desirable derivatives and a concise synthesis route affording more than a gram of a major fragment of anti-HIV agents rubriflordilactones A and B and a specific stereoisomeric analog.

After consulting a lot of data, we found that this compound(1116-98-9)Formula: C7H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1116-98-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Catalytic, Asymmetric Dearomative Synthesis of Complex Cyclohexanes via a Highly Regio- and Stereoselective Arene Cyclopropanation Using α-Cyanodiazoacetates. Author is Smith, Kendrick L.; Padgett, Cody L.; MacKay, William D.; Johnson, Jeffrey S..

In the presence of the nonracemic dirhodium tetracarboxylate Rh2[(S)-PTTL]4, arenes such as PhR [R = H, Me, i-Pr, F, Cl, Br, MeO2C, Ph, TsNHCH2, TBDMSOCH2, TBDMSOCHPh, TBDMSO(CH2)3; Ts = 4-MeC6H4SO2; TBDMS = tert-butyldimethylsilyl] underwent regioselective, diastereoselective, and enantioselective (except for benzene and o-xylene) dearomative cyclopropanation with tert-Bu cyanodiazoacetate to yield cyanobicycloheptadienes (norcaradienes) such as I [R = H, Me, i-Pr, F, Cl, Br, MeO2C, Ph, TsNHCH2, TBDMSOCH2, TBDMSOCHPh, TBDMSO(CH2)3]. I (R = Me, Br, H) were functionalized and desymmetrized (for R = H) by a variety of methods to yield stereochem. dense fused and bicyclic carbocycles containing further modifiable functional groups. I (R = H) underwent racemization in CDCl3 in the presence of hexafluoroisopropanol; anisole and m-xylene underwent ring opening to yield aromatized arylcyanoacetates. The structures of the 4-phenyl-1,2,4-triazoline-3,5-dione adduct of I (R = Me) and of an osmate complex formed in the derivatization of I (R = H) were determined by X-ray crystallog. The cyanodiazoacetate reactants used and the azides used in their preparation are potentially explosive under thermal or phys. shock and should be handled with care.

After consulting a lot of data, we found that this compound(1116-98-9)Related Products of 1116-98-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Xia; Yang, Hanjun; Hu, Xiaotian; Li, Wenting; Fang, Zhimin; Zhang, Kaifeng; Huang, Rui; Li, Jinming; Yang, Zhou; Song, Yanlin published the article 《Low-temperature interfacial engineering for flexible CsPbI2Br perovskite solar cells with high performance beyond 15%》. Keywords: cesium lead bromide iodide perovskite solar cell interfacial engineering.They researched the compound: tert-Butyl 2-cyanoacetate( cas:1116-98-9 ).Application of 1116-98-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1116-98-9) here.

All-inorganic cesium lead halide (CsPbX3) perovskites exhibit superior thermal stability compared to their organic-inorganic hybrid counterparts. The power conversion efficiency (PCE) of CsPbI2Br perovskite solar cells (PSCs) has been over 16%. However, high-temperature annealing limits the feasibility of their application in flexible devices. Here, low-temperature processed flexible CsPbI2Br PSCs are designed by introducing Al-doped ZnO (AZO) as an electron-transport layer and tert-Bu cyanoacetate (t-BCA) as a passivation layer. The thickness-insensitive AZO significantly enhances the quality of the perovskite films and the reproducibility of the PSCs. t-BCA can effectively passivate the trap states and suppress charge recombination of CsPbI2Br films as well. The as-optimized flexible CsPbI2Br PSCs exhibit a high PCE of 15.08% (with an active area of 0.1 cm2), which is one of the highest efficiencies for flexible all-inorganic PSCs. The devices show outstanding stability, retaining 93% of their original PCE after being stored for 60 days, and retaining 91 and 86% of the initial efficiency after continuously heating for 360 h at 85° and storing under 65% RH for 30 h, resp. In addition, the PSCs exhibit excellent mech. stability, and retain 85% of their original value after 1000 bending cycles at a curvature radius of 3 mm.

Although many compounds look similar to this compound(1116-98-9)Application of 1116-98-9, numerous studies have shown that this compound(SMILES:O=C(OC(C)(C)C)CC#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C7H11NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles. Author is Sheng, Heyun; Su, Jianke; Li, Xin; Li, Xue; Song, Qiuling.

An efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with Et bromodi-fluoroacetate as a difluorocarbene source was reported. Through double capture of a difluorocarbene, two different types of fluorine motifs were incorporated into the products with simultaneous construction of one C-N and two C-C bonds, without the need for transition metals. This reaction features high efficiency and excellent functional group compatibility and had great potential in the late-stage modifications of pharmaceutical mols. and natural products.

Although many compounds look similar to this compound(1116-98-9)COA of Formula: C7H11NO2, numerous studies have shown that this compound(SMILES:O=C(OC(C)(C)C)CC#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem