The important role of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 109012-23-9, name is Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109012-23-9, COA of Formula: C7H9N3O4

(1) Capping Step After 1-methyl-4-nitroimidazole-2-carboxylic acid ethyl ester (2.56 g, 12.85 mmol) was dissolved in EA (20 ml), 10% Pd/C (100 mg, catalytic weight) was added thereto. The mixture was stirred for 10 hours at room temperature under hydrogen atmosphere to reduce a nitro group (NO2) into an amino group (NH2), whereby an imidazole-type amino acid was obtained. 10% Pd/C was filtered out by celite 545 filter, and the filtrate was washed with EA and MeOH, and concentrated. To the residue were added carbonic acid 4-nitro-phenyl ester 2-(4-trifluoromethyl-phenylsulfanyl)-ethyl ester (4.52 g, 11.67 mmol) dissolved in anhydrous DCM (40 ml), DIEA (4.06 ml, 23.32 mmol), DMAP (2.85 g, 23.32 mmol), and HOBt (3.57 g, 23.32 mmol), and the mixture was stirred at room temperature. After 12 hours have passed, the reaction was stopped by adding water and the reaction mixture was extracted with DCM. The organic layer was dried over anhydrous MgSO4 and concentrated. The residue was purified by silica gel column chromatography (EA/n-hexane=1/2, v/v) to give 1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)-ethoxycarbonylamino]-1H-imidazole-2-carboxylic acid ethyl ester (3.77 g, 77.40%) of a white solid. TLC (EA/n-hexane=1/2) Rf: 0.14 1H NMR (CDCl3) delta 7.54 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.1 Hz, 2H), 7.31 (brs, 1H), 7.23 (s, 1H), 4.40 (q, J=6.9 Hz, 3H), 4.33 (t, J=7.2 Hz, 2H), 4.00 (s, 3H), 3.26 (t, J=6.9 Hz, 2H), 1.41 (t, J=7.1 Hz, 2H) 13C NMR (CDCl3) 158.50, 152.57, 140.52, 136.92, 131.58, 129.27, 128.33, 127.89, 127.67, 127.46, 127.03, 125.79, 125.75, 125.70, 125.65, 122.07, 118.47, 113.15, 63.33, 61.48, 36.05, 31.10, 14.39

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Han, Hogyu; Jeong, Nakcheol; Lee, SangJo; Oh, Jin Gab; Yu, Hosung; US2003/220469; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem