Category: 1072-84-0

Related Products of 1072-84-0, A common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The nitroimidazole carboxylic acid was readily obtained by nitration of imidazole carboxylic acid (Scheme 2) as previously described [11,23].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jean-Claude, Bertrand; US2012/283280; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1072-84-0, A common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The nitroimidazole carboxylic acid was readily obtained by nitration of imidazole carboxylic acid (Scheme 2) as previously described [11,23].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jean-Claude, Bertrand; US2012/283280; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 1072-84-0, A common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 1H-imidazole-4-carboxylic acid (5.00 g, 44.6 mmol, CAS1072-84-0) in MeOH (50 mL) was added SOCl2 (10.6 g, 89.2 mmol, 6.47 mL). The reaction mixture was stirred at 70 C. for 16 hours. On completion, the reaction mixture was concentrated in vacuo to give the title compound (5.60 g, 99% yield) as white solid. The residue was used to the next step directly without further purification. 1H NMR (400 MHz, DMSO-d6) delta 9.29-9.25 (m, 1H), 8.37 (s, 1H), 3.87 (s, 3H).

The synthetic route of 1072-84-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1072-84-0 as follows. Safety of 1H-Imidazole-4-carboxylic acid

To a solution containing Intermediate 54 (0. 041g) in N, N-DIMETHYLFORMAMIDE (3ML) were added imidazole-4-carboxylic acid (0. 012g, ALDRICH), (1H-1, 2, 3-benzotriazol-1-yloxy) (TRI-1- pyrrolidinyl) phosphonium hexafluorophosphate (PyBop) (0. 053g) and N, N- diisopropylethylamine (0. 03ML). The solution was stirred under nitrogen at room temperature for 18h and was then concentrated in vacuo. The residual gum was purified using an aminopropyl SPE cartridge eluting with methanol followed by chromatography on silica gel (SPE cartridge), eluting with a gradient of 0% to 8% methanol in chloroform, to give the title compound as a yellow solid (0. 031g). LC/MS Rt 2. 32 min, M/Z 549 [MH+]

According to the analysis of related databases, 1072-84-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/103998; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1H-Imidazole-4-carboxylic acid

Example 85 To a solution of 200 mg of 4-[(E)-2-(2,6-dimethylphenyl)vinyl]piperidine monohydrochloride in 5 ml of dimethylformamide, 111 mul of triethylamine, 107 mg of imidazole-4-carboxylic acid, 161 mg of 1-hydroxybenzotriazole and 228 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride were added at ambient temperature. After stirring at ambient temperature overnight, the reaction mixture was concentrated under reduced pressure. After 50 ml of chloroform and 15 ml of saturated aqueous sodium hydrogen carbonate solution were added to the reaction mixture, the organic layer was fractionated and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform-methanol-ammonia water) to give 280 mg of colorless oil. The oil obtained was dissolved in 2 ml of ethanol, and 226 mul of 4N hydrochloric acid-ethyl acetate was added to the solution. The precipitated crystals were collected by filtration and washed with diethyl ether. The crystals were recrystallized from ethanol-diethyl ether to give 191 mg of 4-[(E)-2-(2,6-dimethylphenyl)vinyl]-1-(1H-imidazol-4-ylcarbonyl)piperidine monohydrochloride.

The synthetic route of 1H-Imidazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.; EP1602645; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1072-84-0, These common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1H-Imidazole-4(5)-carboxylic acid (0.560 g, 5 mmol) was dissolved in DMF (20 mL) and a small amount of insoluble solid was filtered off. A cooled (0 C) solution of diazomethane in ether36 was added until no more bubbles were formed. After evaporation of the solvent under reduced pressure the residue was dissolved in ether and washed with water to neutral pH. Then the ethereal solution was dried and evaporated. The product was obtained as a white solid homogeneous by TLC in 40% yield (0.252 g); mp 144-147 C (mp.lit37 = 153-154 C).1H NMR (CD3OD) delta: 7.77(d, J = 4.5 Hz, 2H, NCHNHCH), 3.85(s, 3H, CH3).13C NMR delta: 164.2(COO), 138.6, 126.6, 123.4, 52.0(CH3).Anal. Calcd for C5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.58; H, 4.96; N, 22.12.

The synthetic route of 1072-84-0 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1072-84-0

For synthesis of methyl imidazole-4-carboxylate (5), conc. H2SO4(1.5 mL) was added to a suspension of Im-CO2H (1.00 g, 8.92 mmol)in MeOH (20 mL), and themixture was refluxed for 24 h to give a solutionthat was then cooled to 0 C and neutralized to pH 8 using 5 MNaOH. Evaporation in vacuo left a white residue that was re-dissolvedin a minimal volume of boiling water; cooling the solution depositedwhite crystals of the ester that were collected, washed with cold H2O(1 × 5 mL), and dried in vacuo at r.t. for 24 h. Yield: 0.87 g (77%). 1HNMR (DMSO-d6): delta 7.74 (s, 1H, H5-Im), 7.65 (s, 1H, H2-Im), 2.51 (s,3H, CH3-Im). IR: 3105 (N-H, s), 2976, 2846 (C-H, m), 1619 (C=O,m), 1363 (s), 1156 (m), 864 (m). ESI-MS: 127 (M+). Anal. Calcd. forC5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.5; H, 4.85; N, 21.7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1072-84-0, its application will become more common.

Electric Literature of 1072-84-0,Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Will be 1.34g (12mmol)Imidazole-4-carboxylic acid is dissolved in 40 ml of anhydrous methanol.Add 3ml concentrated sulfuric acid, heat and reflux at 69.6 C for 12h.The reaction was completed until TLC was detected. The reaction solution was spun dry, and sodium hydrogencarbonate was added to adjust to weak acidity.It was diluted with 60 ml of ethyl acetate and the organic phase was washed with saturated sodium chloride (20 ml).Dry over anhydrous sodium sulfate, suction filtration, spin dry,Methyl imidazole-4-carboxylate (yellow brown solid)1.31g,The yield was 79.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4-carboxylic acid, its application will become more common.