Category: 1072-62-4

Application of 1072-62-4, The chemical industry reduces the impact on the environment during synthesis 1072-62-4, name is 2-Ethyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

General procedure: The synthetic route is shown in Scheme 2. For example, to a stirred solution of compound 2 (506mg, 83 1 mmol) in 30 mL acetonitrile were added anhydrous K2CO3 (275 mg, 2mmol) and imidazole (204mg, 3mmol) at 25. Then the mixture was stirred at 25 for 24 h. The reaction mixture was filtered, and the 85 filtrate was evaporated under reduced pressure. The residue was treated with water (50 mL) and extracted 86 with dichloromethane (4¡Á30 mL). The organic layer was combined, dried with anhydrous Na2SO4, and 87 concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography 88 with chloroform/methanol (5:1) as eluent to give compounds 6-24 as solid.compound 6. 4?-(3-Imidazole-propoxy)-arctigenin. Yeild 83.33%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hu, Yang; Liu, Lei; Li, Boyang; Shen, Yufeng; Wang, Gao-Xue; Zhu, Bin; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 183 – 194;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1072-62-4

2-Ethylimidazole (0.756 g, 7.9 mmol) dissolvedin acetonitrile (15 mL) was combined with potassium hydroxide (0.550 g, 9.8mmol) and stirred at 80C for 30 minutes. 2-(Chloromethyl)quinolinehydrochloride (1.45 g, 6.8 mmol) and potassium hydroxide (0.440 g, 7.8 mmol)were added and the mixture was stirred and heated at 80C overnight. Thereaction mixture was filtered to remove a white solid (presumed be potassiumchloride) and the volatiles were removed from the filtrate to yield a yellowoil. The oil was suspended with dichloromethane (25 mL) and washed with a basicaqueous solution (4 x 25 mL) and water (2 x 25 mL). The organic layers weredried with magnesium sulfate and concentrated to a yellow oil. The oil wasresuspended in acetonitrile and 2-(bromomethyl)naphthalene (1.50 g, 6.8 mmol)was added to the solution. The mixture was stirred and heated at 80Covernight. A solid precipitated from the hot acetonitrile. The white solid wasfiltered, washed with acetonitrile, and dried in air to yield 4-Br (.715 g, 23% yield). MP =215-216C. HRMS (ESI+) calcdfor C26H24N3+ [M-Br] of m/z =378.1965, found m/z = 378.1942. 1H NMR (500 MHz, DMSO- d6) delta = 8.48 (1H, d, Ar, J =8.3 Hz), 8.03 (2H, t, Ar, J = 8.8 Hz), 7.98 (1H, m, Ar), 7.93 (1H, m, Ar), 7.90(3H, m, Ar), 7.76 (2H, m, Ar), 7.61 (4H, m, Ar), 7.50 (1H, m, Ar), 5.88 (2H, s,CH2), 5.74 (2H, s, CH2), 3.17 (2H, q, CH2, J= 7.6 Hz) 0.94 (3H, t, CH3, J = 7.6 Hz). 13C NMR (125MHz, DMSO- d6) delta = 154.2(Ar), 149.1 (Ar), 146.7 (Ar), 137.4 (Ar), 132.7 (Ar), 132.5 (Ar), 132.4 (Ar),130.1 (Ar), 128.7 (Ar), 128.3 (Ar), 128.0 (Ar), 127.7 (Ar), 127.7 (Ar), 127.1(Ar), 126.9 (Ar), 126.7 (Ar), 126.6 (Ar), 126.4 (Ar), 125.0 (Ar), 123.1 (Ar),122.1 (Ar), 119.8 (Ar), 52.3 (CH2), 50.8 (CH2), 16.6 (CH2),11.2 (CH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1072-62-4, its application will become more common.

Reference:
Article; DeBord, Michael A.; Wagers, Patrick O.; Crabtree, Steven R.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 196 – 202;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Ethyl-1H-imidazole

To a stirred slurry of9.95 g (0.125 mole) copper oxide in 100 mL 2% aqueous acetic acid at 95 0C was added 25.24 g (0.263 mole) 2-ethylimidazole. The mixture was brought to a boil and maintained under reflux for several hours. The resulting slurry was filtered and the solids washed with water and dried at 105 0C to give a brown powder. The product (23.92 g, 75% yield) gave a unique X-ray diffraction pattern and was confirmed to have the composition of copper 2- ethylimidazolate, by elemental analysis. Some unreacted copper oxide was present in the product.

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; U.S. BORAX INC.; WO2007/87434; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem