Category: 1072-62-4

Synthetic Route of 1072-62-4, These common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-ethylimidazole (15.000 g; 156.03 mmol; 1.0 eq.) in dioxane (250 ml), and water (250 ml) was added at rt (in one portion) successively Na2CO3 (49.614 g; 468.10 mmol; 3.0 eq.), and iodine (87.126 g; 343.27 mmol; 2.2 eq.). The resulting brown heterogeneous reaction mixture was further stirred at rt, under nitrogen, for 24 h. AcOEt (500 ml) was then added followed by an aq. solution of sodium thiosulfate (45.0 g Na2S2O3 in 300 ml of water). The yellow organic layer was separated, and additionally washed with an aq. solution of sodium thiosulfate (30.0 g Na2S2O3 in 300 ml of water), and finally with brine (200 ml). The resulting yellow organic layer was then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure to give 2-ethyl-4,5-diiodo-1H-imidazole as a pale yellow solid which was further dried under HV (49.760 g; 92%). LC-MS: tR=0.55 min.; [M+H]+: 349.18 g/mol.

Statistics shows that 2-Ethyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 1072-62-4.

Reference:
Patent; Aissaoui, Hamed; Boss, Christoph; Koberstein, Ralf; Siegrist, Romain; Sifferlen, Thierry; US2011/105514; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., name: 2-Ethyl-1H-imidazole

The after-dihydro-furo indanol (6,1.76g, 10mmol) was dissolved in toluene (in 80 ml of), was added thionyl chloride (4.91ml, 30.4mmol), for 2 hours at 55 was heated with stirring, and concentrated under reduced pressure , was prepared chloro; which was dissolved in toluene or acetonitrile solvent (in 80 ml of), was added 2-ethyl imidazole (2.88g, 30mmol), the reaction was stirred at reflux for 24-48 hours. after the solvent was concentrated under reduced pressure, purified by silica gel column chromatography chromatography (100-200 mesh), petroleum ether – ethyl acetate (3:1 ? 1:1) as eluent, to give preparation of 1- (furo-dihydro-inden-alkoxy) -2-ethyl imidazole (8c, 1.52 g), yield 60%;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Yunnan University; Yang Xiaodong; Zhang Hongbin; Chen Wen; Wang Xuequan; Yang Lijuan; Li Liang; (38 pag.)CN102766135; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1072-62-4 as follows. SDS of cas: 1072-62-4

EXAMPLE 2 2-Ethyl-4,5-dihydroxymethylimidazole The procedure described in Example 1 is followed, except that 96 g (1 mole) of 2-ethylimidazole are used instead of 2-methylimidazole. The 155 g of crude product obtained in this procedure are stirred with 52 g of methanol for 30 minutes at 50 C. and at 10 C. with cooling. The mixture is filtered, the product is washed with twice 150 ml of acetone and dried in a drying oven, and 117.5 g of 2-ethyl-4,5-dihydroxymethylimidazole of melting point 173.35-174.0 C. are obtained. This corresponds to a yield of 75.4%. The purity of this sample is 99.8% according to HPLC. Elemental analysis: Mass spectrum: M+ 156. 1 H-NMR spectrum (solvent DDMSO) 1.15 (t, 1p) 2.55 (q, 2p) 4.4 (s, 4p).

According to the analysis of related databases, 1072-62-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF Aktiengesellschaft; US4658035; (1987); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-62-4, SDS of cas: 1072-62-4

The 400mg4-amino-6-chloro-pyrimidine, 317 mg (1.1equiv) 2-ethyl imidazole, 1.2g (1.2equiv) adding cesium carbonate flask, 10mLN, N ‘-dimethyl formamide as a solvent, the temperature is increased to 120 C, reaction 18h. Adding proper amount of water, extraction with ethyl acetate, saturated salt water washing, drying by anhydrous sodium sulfate, filter, evaporate solvents under reduced pressure, the residue is purified by silica gel column chromatography separation, methanol/dichloromethane = 1/30 elution, to get the yellow solid 105 mg, yield 18%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; East China University of Technology; Mao, Fei; Wang, Huan; Li, Xiaokang; Zhang, Haiyan; Lu, Zhengyu; Li, Jian; (43 pag.)CN105418592; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1072-62-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-62-4, name is 2-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The synthetic route is shown in Scheme 2. For example, to a stirred solution of compound 2 (506mg, 83 1 mmol) in 30 mL acetonitrile were added anhydrous K2CO3 (275 mg, 2mmol) and imidazole (204mg, 3mmol) at 25. Then the mixture was stirred at 25 for 24 h. The reaction mixture was filtered, and the 85 filtrate was evaporated under reduced pressure. The residue was treated with water (50 mL) and extracted 86 with dichloromethane (4×30 mL). The organic layer was combined, dried with anhydrous Na2SO4, and 87 concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography 88 with chloroform/methanol (5:1) as eluent to give compounds 6-24 as solid.compound 6. 4?-(3-Imidazole-propoxy)-arctigenin. Yeild 83.33%.

The synthetic route of 2-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yang; Liu, Lei; Li, Boyang; Shen, Yufeng; Wang, Gao-Xue; Zhu, Bin; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 183 – 194;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 1072-62-4,Some common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (bromomethyl)-5-fluorophenyl)(2-fluoro-4,5-dimethoxyphenyl)methanone 4 (0.25 g, 0.68 mmol, 1.0 equiv) and 4-hydroxyl piperidine (150 muL, 1.35 mmol, 2.0 equiv) weredissolved in anhydrous dichloromethane (10 mL) and dryK2CO3 (100 mg, 0.72 mmol, 1.1 equiv) was added, and thenthe mixture was stirred at room temperature for 12 h. Thesolvent was removed by rotary evaporation and the residuewas purified by flash column chromatography over silica gelwith the system (14% ethyl acetate/petroleum ether, adding1.4% ammonia water) to obtain compound (5-fluoro-2-((4-hydroxypiperidin-1-yl)methyl)phenyl) 2-fluoro-4,5-dimethoxyphenyl)methanone 5a (0.2 g, 77%) as a yellow solid.The intermediates 5b-5g, 7a-7k, 9a-9g, 11a-11b wereprepared in a similar manner

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Feng, Xiu E; Kong, De Peng; Ban, Shu Rong; Ge, Rui; Li, Qing Shan; Medicinal Chemistry Research; vol. 28; 8; (2019); p. 1319 – 1337;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1072-62-4, These common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

40 mmol of 2-ethylimidazole was dissolved in 20 ml of dimethylsulfoxide (DMS0), and the mixture was milledNa0H80mmol, heated to 60 C, then add 40mmol chloromethyl benzotriazole, 60 C water bath heating lh, cooling to room temperature,Poured into 100g ice water, stirring, precipitation, filtration, precipitation washed 3 times with water to get crude;The crude product was recrystallized from ethyl acetate to give the colored crystals as the ligand 1- (benzotriazole-1-methyl) -1- (2-ethylimidazole).

Statistics shows that 2-Ethyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 1072-62-4.

Reference:
Patent; Henan College of Traditional Chinese Medicine; Wang, Xia; Zhang, Chao; Ceng, Dai; Cheng, Di; Song, Ning; Yang, Huai Xia; (11 pag.)(2016);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1072-62-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-62-4 name is 2-Ethyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Taking 2 – ethyl imidazole 9.6g (0.1 muM), KOH 8.4g (0.15 muM), K2CO313 . 8g (0.1 muM) and tetrabutyl ammonium bromide 1.6g (0.005 muM) dissolved in 75 ml dichloromethane in, room temperature stirring 0.5h after, slow instillment bromine ethyl acetate 0.1 muM (11.2 ml), dropwise, 39 C reflow 8h, filtering, saturated salt water washed filtrate three times, dried with anhydrous sodium sulfate, 25 C distilling the organic phase to liquid droplet not to trickle out, obtaining oil object, i.e. the compound III intermediate 1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Atomic Medical Institute; Qiu Ling; Lin Jianguo; Lv Gaochao; Li Ke; Peng Ying; Luo Shineng; Wang Shanshan; Zhao Xueyu; (27 pag.)CN106749406; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 1072-62-4

General procedure: A vessel with a magnetic stirrer bar was charged with imidazole derivative (0.5 mmol), CuI (10 mg, 0.05 mmol), Cs2CO3 (0.33 g, 1 mmol), PPh3 (26 mg, 0.1 mmol) and tetrabutylammonium bromide (TBAB) (0.2 g, 0.6 mmol) under a nitrogen atmosphere. The reaction vessel was evacuated and backfilled with nitrogen three times. In a separate flask, a solution of dry dioxane (2 mL) containing the 1,1-dihalo-1-alkenes (1 mmol) was evacuated and back-filled with nitrogen gas three times. The dioxane solution was then added to the reaction flask via a syringe and the reaction mixture heated to 100 C for 30 hours. The reaction mixture was cooled to room temperature, quenched with 5 mL of a saturated NH4Cl solution, and extracted with ethyl acetate (3 x 10 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash column chromatography with ethyl acetate (EA) and petroleum ether (Pet) as the eluent to afford the corresponding products:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 1072-62-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-62-4 name is 2-Ethyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of the appropriate bromoacetophenone 1 or 2 (0.500mmol), appropriate benzimidazole or imidazole (0.750 mmol), andsodium acetate (49.2 mg, 0.600 mmol) in tetrahydrofuran (3 ml)was stirred at room temperature for 24 h. The reaction mixturewas poured into water. The precipitate was filtered off, washedwith water, and then with diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethyl-1H-imidazole, and friends who are interested can also refer to it.