Category: 1072-62-4

Synthetic Route of 1072-62-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-62-4, name is 2-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The synthetic route is shown in Scheme 2. For example, to a stirred solution of compound 2 (506mg, 83 1 mmol) in 30 mL acetonitrile were added anhydrous K2CO3 (275 mg, 2mmol) and imidazole (204mg, 3mmol) at 25. Then the mixture was stirred at 25 for 24 h. The reaction mixture was filtered, and the 85 filtrate was evaporated under reduced pressure. The residue was treated with water (50 mL) and extracted 86 with dichloromethane (4×30 mL). The organic layer was combined, dried with anhydrous Na2SO4, and 87 concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography 88 with chloroform/methanol (5:1) as eluent to give compounds 6-24 as solid.compound 6. 4?-(3-Imidazole-propoxy)-arctigenin. Yeild 83.33%.

The synthetic route of 2-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yang; Liu, Lei; Li, Boyang; Shen, Yufeng; Wang, Gao-Xue; Zhu, Bin; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 183 – 194;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 1072-62-4,Some common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (bromomethyl)-5-fluorophenyl)(2-fluoro-4,5-dimethoxyphenyl)methanone 4 (0.25 g, 0.68 mmol, 1.0 equiv) and 4-hydroxyl piperidine (150 muL, 1.35 mmol, 2.0 equiv) weredissolved in anhydrous dichloromethane (10 mL) and dryK2CO3 (100 mg, 0.72 mmol, 1.1 equiv) was added, and thenthe mixture was stirred at room temperature for 12 h. Thesolvent was removed by rotary evaporation and the residuewas purified by flash column chromatography over silica gelwith the system (14% ethyl acetate/petroleum ether, adding1.4% ammonia water) to obtain compound (5-fluoro-2-((4-hydroxypiperidin-1-yl)methyl)phenyl) 2-fluoro-4,5-dimethoxyphenyl)methanone 5a (0.2 g, 77%) as a yellow solid.The intermediates 5b-5g, 7a-7k, 9a-9g, 11a-11b wereprepared in a similar manner

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Feng, Xiu E; Kong, De Peng; Ban, Shu Rong; Ge, Rui; Li, Qing Shan; Medicinal Chemistry Research; vol. 28; 8; (2019); p. 1319 – 1337;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Ethyl-1H-imidazole

To a stirred slurry of9.95 g (0.125 mole) copper oxide in 100 mL 2% aqueous acetic acid at 95 0C was added 25.24 g (0.263 mole) 2-ethylimidazole. The mixture was brought to a boil and maintained under reflux for several hours. The resulting slurry was filtered and the solids washed with water and dried at 105 0C to give a brown powder. The product (23.92 g, 75% yield) gave a unique X-ray diffraction pattern and was confirmed to have the composition of copper 2- ethylimidazolate, by elemental analysis. Some unreacted copper oxide was present in the product.

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; U.S. BORAX INC.; WO2007/87434; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1072-62-4, These common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

40 mmol of 2-ethylimidazole was dissolved in 20 ml of dimethylsulfoxide (DMS0), and the mixture was milledNa0H80mmol, heated to 60 C, then add 40mmol chloromethyl benzotriazole, 60 C water bath heating lh, cooling to room temperature,Poured into 100g ice water, stirring, precipitation, filtration, precipitation washed 3 times with water to get crude;The crude product was recrystallized from ethyl acetate to give the colored crystals as the ligand 1- (benzotriazole-1-methyl) -1- (2-ethylimidazole).

Statistics shows that 2-Ethyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 1072-62-4.

Reference:
Patent; Henan College of Traditional Chinese Medicine; Wang, Xia; Zhang, Chao; Ceng, Dai; Cheng, Di; Song, Ning; Yang, Huai Xia; (11 pag.)(2016);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-62-4, name is 2-Ethyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1072-62-4

In an argon stream, 2-ethylimidazole (1.92 g, 20 mmol) and sodium hydride (0.84 g, 21 mmol) were suspended in tetrahydrofuran (30 mL) and cooled to 0 C. 1-Iodohexane (4.67 g, 22 mmol) was added to the suspension, and the mixture was stirred at room temperature for 30 minutes and then at 75 C. for 24 hours. After standing to cool, diethyl ether and water were added to the reaction mixture, the organic layer was extracted, and the organic layer was washed with brine. After adding sodium sulfate to the organic layer and stirring, the solid was filtered off and the solvent was distilled off. The resulting oily substance was purified by silica gel column chromatography (chloroform / methanol = 10: 1) to obtain 1-hexyl-2-ethylimidazole as a yellow oily substance (2.93 g, 81%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1072-62-4.

Reference:
Patent; Tosoh Corporation; Sagami Chemical Research Institute; Aihara, Hidenori; Yamagata, Takuya; Hachiya, Hitoshi; Watanabe, Makoto; Fukuda, Takashi; Ueda, Saori; Miyashita, Masato; (64 pag.)JP2018/168149; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Ethyl-1H-imidazole

General procedure: To a solution of (benzofuran-2-yl)(phenyl)methanol 4 (224 mg, 1 mmol) in dichloromethane (50 mL) was added methanesulfonyl chloride (1.2 mmol) and triethylamine (2 mmol) at 0 oC. The resulting mixture was stirred at room temperature for 12 h. After quenching the reaction with water (50 mL), the layers were separated. The organic phase was dried over anhydrous Na2SO4 and concentrated, and used for the next synthetic step. A mixture of the previous methanesulfonate and imidazole or substituted imidazole (3 mmol) was stirred in acetonitrile (20 ml) at reflux for 24-48 h (monitored by TLC). After cooling to room temperature, the solvent was concentrated, and the residue was diluted with EtOAc (20 mL). The organic layer was washed with water (20 mL) and brine (20 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography (silica gel, petroleum ether 60-90 oC : ethyl acetate = 3:1?1:1) to afford 6-9 in 60-75% yield (two steps) as yellow oil or powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Xue-Quan; Liu, Lan-Xiang; Li, Yan; Sun, Cheng-Jun; Chen, Wen; Li, Liang; Zhang, Hong-Bin; Yang, Xiao-Dong; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 111 – 121;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 1072-62-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-62-4, name is 2-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide A mixture of 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester (3.0 g), 2-ethylimidazole (0.73 g) and ethyldiisopropylamine (2.0 mL) in N-methyl-2-pyrrolidinone (10 mL) is stirred for 12 h at 80 C. The solvent is removed in vacuo and the residue is purified by HPLC (C18 RP Sunfire, H2O/MeOH+0.1% TFA) to yield the boc-protected intermediate. The intermediate is dissolved in dichloromethane and dichloromethane/trifluoroacetic acid (1:1, 5% H2O) is added and the mixture is stirred for 5 h at room temperature. After concentration in vacuo the residue is triturated with diethyl ether to afford the title compound as a trifluoroacetic acid salt. LC (method 10): tR=1.56 min; Mass spectrum (ESI+): m/z=341 [M+H]+.

The synthetic route of 2-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Neurocrine Biosciences, Inc.; Boehringer Ingelheim International GmbH; NOSSE, Bernd; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; ASHWEEK, Neil J.; HARRIOTT, Nicole; US2014/45823; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., Formula: C5H8N2

(a) 3-[3-(2-Ethylimidazol-l-ylmethyl)phenyl]-5-z^o-butyl-7V-fe7Y-butylthiophene- 2-sulfonamide; To a solution of 3-(3-bromomethylphenyl)-5-ziO-butyl-7V-fe7t-butylthiophene-2- sulfonamide (70 mg, 0.158 mmol; see Example l(e)) in dioxane (2.0 mL) was added 2-ethylimidazole (45.4 mg, 0.473 mmol) and the reaction mixture was stirred for 1 h at 80C. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography using MeOH:CH2Cl2 (6:94) as EPO eluent to give the sub-title compound in 85% yield as a colourless syrup (61.2 mg, 0.134 mmol).1H NMR delta (CDCl3): 0.95(s, 9H)5 0.96 (d, J= 6.5 Hz5 6H), 1.29 (t, J= 7.3 Hz5 3H)5 1.80-1.98(m, IH), 2.58-2.72 (m, 4H)5 4.11 (br s, IH)5 5.08 (s, 2H)5 6.70 (s, IH), 6.88 (s5 IH)5 6.98 (s, IH)5 7.08 (d, J – 7.7 Hz5 IH)5 7.39 (apparent t, J = 7.7Hz, IH)5 7.42 (s5 IH)5 7.51 (d, J= 7.7 Hz5 IH).13C NMR delta (CDCl3): 11.9, 20.2, 22.1, 29.4, 30.5, 39.1, 49.1, 54.5, 119.6, 126.7, 127.5, 127.7, 128.5, 128.7, 129.0, 135.5, 136.6, 136.9, 142.3, 148.5, 149.4. IR v (neat, cm”1): 3283, 3053, 2966, 2870, 1493, 1465, 1430, 1313. MS (ESI) m/z: 460 (M+H)+.Anal. Calcd. for C24H33N3O2S2- 1/2H2O: C, 61.50; H, 7.31; N, 8.97. Found: C, 61.53; H, 7.36; N5 8.99.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; VICORE PHARMA AB; WO2006/109048; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C5H8N2

2-Ethyl imidazole (1.01 g, 10.5 mmol) dissolvedin acetonitrile (25 mL) was combined with potassium hydroxide (0.58 g, 10.3mmol) and stirred for 30 minutes at 80C. 2-(Bromomethyl)naphthalene (1.73 g, 7.8 mmol) was added and the mixture wasstirred and heated at 80C overnight. The reaction mixture was filtered toremove a white solid (presumed to be potassium bromide) and the volatiles wereremoved from the filtrate to yield a yellow oil. The oil was suspended withdichloromethane (40 mL) and washed with a basic aqueous solution (1 x 30 mL)and water (3 x 30 mL). The organic layers were dried with magnesium sulfate andconcentrated to a yellow oil. The oil was resuspended in acetonitrile (7 mL)and 2-(chloromethyl)quinoline (1.59 g, 9.0 mmol) was added to the solution. Themixture was stirred and heated at 80C overnight. A white solid precipitatedfrom the hot acetonitrile and was filtered, washed with acetonitrile, and driedin air to yield 4-Cl (0.850 yield). MP = 204-207C. HRMS (ESI+) calcd for C26H24N3+[M-Cl] of m/z = 378.1965, found m/z = 378.2000. 1H NMR (500 MHz,DMSO- d6) delta = 8.48 (1H, d,Ar, J = 8.8 Hz), 8.03 (2H, t, Ar, J = 8.3 Hz), 7.98 (1H, m, Ar), 7.93 (3H, m,Ar), 7.90 (1H, m, Ar), 7.76 (2H, m, Ar), 7.64 (2H, m, Ar), 7.58 (2H, m, Ar),7.50 (1H, m, Ar), 5.90 (2H, s, CH2), 5.76 (2H, s, CH2),3.17 (2H, q, CH2, J = 7.6 Hz) 0.93 (3H, t, CH3, J = 7.6Hz). 13C NMR (125 MHz, DMSO- d6)delta = 154.2 (Ar), 149.1 (Ar), 146.7 (Ar), 137.4 (Ar), 132.7 (Ar), 132.5 (Ar),132.5 (Ar), 130.1 (Ar), 128.7 (Ar), 128.3 (Ar), 128.0 (Ar), 127.7 (Ar), 127.7(Ar), 127.2 (Ar), 126.9 (Ar), 126.7 (Ar), 126.6 (Ar), 126.4 (Ar), 125.0 (Ar),123.1 (Ar), 122.2 (Ar), 119.9 (Ar), 52.2 (CH2), 50.8 (CH2),16.6 (CH2), 11.2 (CH3). Crystal data for 4-Cl?H2O: C26H26N3O1Cl1,M = 431.95, Monoclinic, a =34.6333(13) A, b = 9.5796(4) A, c = 13.6475(5) A, beta = 92.286(2), V = 4524.8(3) A3, T = 100(2) K, space group C2/c, Z= 8, 16910 reflections measured, 4589 [R(int) = 0.0411]. The final R1 values were 0.0475 (I > 2sigma(I)). The final wR(F2)values were 0.1118 (I > 2sigma(I)).The final R1 values were0.0650 (all data). The final wR(F2) values were 0.1215 (alldata).

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; DeBord, Michael A.; Wagers, Patrick O.; Crabtree, Steven R.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 196 – 202;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H8N2

General procedure: To a solution of 1 (0.02 mmol) in H2O/MeCN (v/v=2/1, 4 mL) was added 1H-imidazole (1.0 mmol) and arylboronic acid (2 mmol)under O2 atmosphere. The mixture was stirred at 60 C for 24 h. After cooling to ambient temperature, the mixture was partitioned between water and CH2Cl2. The organic layer was separated, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel.

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xue, Jiang-Yan; Li, Jun-Chi; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 72; 44; (2016); p. 7014 – 7020;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem