Category: 106961-33-5

Eswaraiah, P. et al. published their research in Journal of Chemical and Pharmaceutical Research in 2016 | CAS: 106961-33-5

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 106961-33-5

A novel and efficient process for the preparation of zolpidem, an insomnia drug was written by Eswaraiah, P.;Ravi, Kumar Reddy N.;Chakravarthy, I. E.;Prasada, Rao D. E.;Rajendiran, C.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Recommanded Product: 106961-33-5 This article mentions the following:

Zolpidem, is an imidazopyridine group of non-benzodiazepine class drug, used for the treatment of insomnia. Here with presenting a new approach for the synthesis zolpidem without isolation of intermediates. The modified process is efficient, cost effective, simplified work up process and scalable synthesis of zolpidem with reducing cycle time. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Recommanded Product: 106961-33-5).

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 106961-33-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aanandhi, M. Vijey et al. published their research in Inventi Impact: Med Chem in 2014 | CAS: 106961-33-5

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine

Synthesis, docking and biological activity of various substituted zolpidem based GABAA inhibitors endowed potent hypnotic and sedative activity was written by Aanandhi, M. Vijey;Bhattacherjee, Debojit;Kamalraj, R.. And the article was included in Inventi Impact: Med Chem in 2014.Recommanded Product: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine This article mentions the following:

Synthesis, characterization, biol. profiling and mol. docking studies were carried out to understand the biol. activity and binding selectivity of the Zolpidem based compounds I (R1 = 3-CH3, 4-CH3, 5-CH3; R2 = NMe2, diisopropylamine). The study indicates that substituted zolpidem based compounds showed potent phenobarbitone induced hypnosis as well as locomotor activity throughout the study. Compounds I (R1 = 3-CH3; R2 = NMe2, diisopropylamine) produced significant reduction in onset and prolongation of sleep duration induced by phenobarbitone. In the second model (locomotor activity in actophotometer) activity was found to be maximum for I (R1 = 3-CH3; R2 = NMe2, diisopropylamine) (30 mg/kg), produced 31.2 and 33.2% decrease in locomotor activity, where standard drug phenobarbitone produced 59.37% decrease in activity. Mol. docking studies also concluded the selectivity of compound I (R1 = 3-CH3, R2 = diisopropylamine) was appreciable in respect to the standard The binding energy and the bond distances of phenobarbitone and compound I (R1 = 3-CH3, R2 = diisopropylamine) between the target were found to be -7.24 kcal and -6.6 kcal and 2.829 脜 (PRO 85), 1.896 脜 (PHE 78), (LEU 76) resp. The study revealed the possibilities in future research of zolpidem based derivatives for establishment of new generation CNS acting agents. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Recommanded Product: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine).

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem