Category: 10394-40-8

Synthetic Route of 10394-40-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10394-40-8 as follows.

STR44 An aqueous solution (100 ml) of 3.95 g of 1,6-dimethylbenzimidazole and 10 g of potassium permanganate was stirred at 50 C. for 2 hours and 2 g of potassium permanganate was further added to the mixture. The mixture was stirred at 80 C. for further 2 hours. After insoluble matters were filtered off, the filtrate was rendered pH 4 with 1 N hydrochloric acid and concentrated under reduced pressure to give 7.33 g of 1-methylbenzimidazole-6-carboxylic acid as the mixture with potassium chloride. The above compound was heated to reflux in 150 ml of methanol overnight in the presence of 3 ml of conc. sulfuric acid. The reaction solution was concentrated under reduced pressure and water was added to the concentrate.

According to the analysis of related databases, 10394-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4977175; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 10394-40-8,Some common heterocyclic compound, 10394-40-8, name is 1,6-Dimethyl-1H-benzo[d]imidazole, molecular formula is C9H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

STR44 An aqueous solution (100 ml) of 3.95 g of 1,6-dimethylbenzimidazole and 10 g of potassium permanganate was stirred at 50 C. for 2 hours and 2 g of potassium permanganate was further added to the mixture. The mixture was stirred at 80 C. for further 2 hours. After insoluble matters were filtered off, the filtrate was rendered pH 4 with 1 N hydrochloric acid and concentrated under reduced pressure to give 7.33 g of 1-methylbenzimidazole-6-carboxylic acid as the mixture with potassium chloride. The above compound was heated to reflux in 150 ml of methanol overnight in the presence of 3 ml of conc. sulfuric acid. The reaction solution was concentrated under reduced pressure and water was added to the concentrate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,6-Dimethyl-1H-benzo[d]imidazole, its application will become more common.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4977175; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem