Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1038408-36-4, name is 6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Product Details of 1038408-36-4
Under nitrogen protection, TCHP (460 mg) and Pd(Oac)2 (230 mg) were added into the mixture of 228 6-bromo-2-methyl-1-isopropyl-1H-benzo[d]imidazole (2.30 g, 9.10 mmol), 27 bis(pinacolato)diboron (3.50 g, 13.6 mmol) and 28 potassium acetate (2.70 g, 27.3 mmol) in anhydrous 29 DMSO (25 mL), and the reaction was reacted under nitrogen protection at 100 C. for 2 hrs. After cooling to room temperature, the reaction was quenched by adding 48 water, extracted with ethyl acetate (100 mL¡Á3), the organic layer was combined, washed with brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and the filtrate was separated on column chromatography (eluant:petroleum ether/ethyl acetate (v/v)=2:1), to afford 1.60 g of a brown-yellow solid, yield was 58.6%. LC-MS(APCI): m/z=301.2 (M+1).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shenzhen TargetRx, Inc.; Wang, Yihan; Ren, Xingye; Jin, Jian; Li, Huanyin; Ai, Yixin; (162 pag.)US2019/152954; (2019); A1;,
Imidazole – Wikipedia,
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