10351-75-4 Archives - Imidazoles-derivatives

Sep-21 News A new synthetic route of 10351-75-4

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C9H6N2O4

General procedure: A mixture of Cd(NO3)2·4H2O (0.0308 g, 0.1 mmol), H3BIDC (0.0412 g, 0.2 mmol) and phen (0.0396 g, 0.2 mmol) with a molar ratio of 1:2:2 were dissolved in the distilled water (5 mL), and stired for 25 min, then set in a Teflon-lined autoclave and heating at 160 C for five days. After cooling to the room temperature, yellow block crystals were obtained. Yield: 28.84 mg (77%, on Cd(II) cations). The products were washed by distilled water and dried in air.

Reference:
Article; Fan, Rui-Qing; Wang, Li-Yuan; Wang, Ping; Chen, Hong; Sun, Cun-Fa; Yang, Yu-Lin; Su, Qing; Journal of Solid State Chemistry; vol. 196; (2012); p. 332 – 340,9;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of 10351-75-4

Statistics shows that 1H-Benzo[d]imidazole-5,6-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 10351-75-4.

Related Products of 10351-75-4, These common heterocyclic compound, 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture containing Eu2O3 (0.2 mmol), MnSO4*H2O (0.3 mmol), H3bidc (0.6 mmol) and water (10 mL) was sealed in a Teflon-lined stainless steel vessel (23 mL), which was heated at 170 C for 4 days and then cooled to room temperature in 2 days. Colorless rhombic crystals of 2 were obtained and picked out, washed with distilled water and dried in air (Yield: 38.17% based on Eu).

Statistics shows that 1H-Benzo[d]imidazole-5,6-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 10351-75-4.

Reference:
Article; Sun, Ya-Guang; Zong, Wen-Hui; Xiong, Gang; Guo, Mei-Yan; Ding, Fu; Wang, Shu-Ju; You, Li-Xin; Ren, Bao-Yi; Xu, Zhen-He; Gao, En-Jun; Polyhedron; vol. 83; (2014); p. 68 – 76;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of 10351-75-4

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10351-75-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1H-Benzo[d]imidazole-5,6-dicarboxylic acid

Step A: 5,6-di-(methoxycarbonyl)-benzimidazole To a solution of 200 mg of 5,6-benzimidazoledicarboxylic acid dissolved in 2.0 mL of MeOH and 2.0 mL of diethyll ether was added 4 mL of trimethylsilyldiazomethane [2.0 M in hexanes]. The resulting solution was stirred for 1 hour before dilution with 20 mL of H2O and extraction with 2*10 mL of EtOAc. the organic phases were dried over MgSO4 and concentrated under reduced pressure. Column chromatography (SiO2, 5% MeOH in CH2Cl2) yielded 210 mg of the title compound as a yellow oil. Mass Spectrum (ESI) 231 (M+1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10351-75-4.

Reference:
Patent; Merck & Co., Inc.; US6498165; (2002); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analyzing the synthesis route of 10351-75-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, its application will become more common.

Application of 10351-75-4,Some common heterocyclic compound, 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, molecular formula is C9H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A reaction mixture of MnCl2 (0.2 mmol, 25.2 mg), H3bidc(0.1 mmol, 20.6 mg), and phen (0.1 mmol, 19.8 mg), H2O(4mL) and DMF (4 mL) was stirred for half an hour, thentransferred and sealed in a 10 mL glassflask. The system washeated in an oven at 85C for 24 hours and cooled to roomtemperature. Accordingly colourless block crystals were isolated by filtering, washed with distilled water and dried at inair. The yield of colorless crystalline product was 58% (basedon Mn). Anal. Calcd for C9H6N2O5Mn: C, 38.98; H, 2.17;N, 10.10%. Found: C, 38.85; H, 2.04; N, 10.02%. IR (KBrcm1): 3398(s), 3119(s), 1548(s), 1412(s), 1270(w), 1176(s),1122(s), 959(m), 876(m), 804(m), 629(w), 589(w), 429(m).

Reference:
Article; Zhang, Huijie; Zhou, Guangpeng; Fan, Ruiqing; Wang, Xinming; Yang, Yulin; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 46; 8; (2016); p. 1224 – 1235;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The origin of a common compound about C9H6N2O4

Reference of 10351-75-4,Some common heterocyclic compound, 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, molecular formula is C9H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Europium oxide (0.1 mmol, 35.2 mg),H3bidc (41.2 mg, 0.2 mmol) and a solution (1 ml) of oxalic acid(0.1 M) were dissolved in water (10 ml) at room temperature.After continuous stirring for 10 min, the mixture was sealed ina Teflon-lined stainless steel vessel (23 ml), heated at 180 C for 3 d under autogenous pressure and cooled slowly to room temperature. Yellow block-shaped crystals of 1 were harvestedin a yield of 80% (based on Eu). Elemental analysis (%)calculated for C10H8EuN2O8: C 27.54, H 1.85, N 6.42; found: C27.32, H 1.90, N 6.51. IR (KBr, cm-1): 3130 (m, br), 1680 (s),1620 (m), 1575 (s), 1410 (w), 1380 (m), 1209 (m), 1102 (s), 1110(vs), 1000 (m), 890 (s), 813 (m), 650 (w), 580 (w).

Reference:
Article; Wenxu, Zheng; Wu, Kechen; Acta Crystallographica Section C: Structural Chemistry; vol. 76; (2020); p. 186 – 192;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sources of common compounds: 10351-75-4

The chemical industry reduces the impact on the environment during synthesis 1H-Benzo[d]imidazole-5,6-dicarboxylic acid. I believe this compound will play a more active role in future production and life.

Synthetic Route of 10351-75-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

2.2.1 H24-DPBB A mixture of benzimidazole-5,6-dicarboxylic acid (2.0616 g, 10 mmol) and 4-aminobenzoic acid (1.3714 g, 10 mmol) in 30 ml DMF was heated at 135 C for 10 h, then filtrated. The product was washed several time with hot DMF and EtOH, then dried in air. Yield: 70%. Element analysis (%): Anal. Calc. for C16H9N3O4: C 62.54, H 2.95, N 13.68. Found: C 62.55, H 2.91, N 13.65%. IR (KBr pellet, cm-1): 3340(m), 3050(s), 1770(m), 1713(vs), 1605(m), 1509(m), 1371(vs), 1264(vs), 1118(m), 865(s), 835(s), 610(s). Negative ESI-MS (m/z): 305.98 (H24-DPBB-H+). 1H NMR (DMSO-d6): delta: 7.630 (J = 4.8 Hz, d, 2H, Ph-H), 8.097 (J = 1.2 Hz, d, 2H, Ph-H), 8.114 (s, 1H, Ph-H), 8.208 (s, 1H, Ph-H), 8.602 (s, 1H, Im-H), 13.320 (s, 1H, COOH). Melting points: above 300 C.

Reference:
Article; Yang, Jing-Si; Zhu, Jiang; Liu, Rui-Bin; Ni, Jun; Chang, Zhi-Duo; Hu, Tao; Zhang, Jian-Jun; Meng, Chang-Gong; Inorganica Chimica Acta; vol. 394; (2013); p. 117 – 126;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sources of common compounds: 1H-Benzo[d]imidazole-5,6-dicarboxylic acid

The synthetic route of 10351-75-4 has been constantly updated, and we look forward to future research findings.

A mixture of Cd(NO3)2·4H2O (0.0308 g, 0.1 mmol), H3BIDC (0.0412 g, 0.2 mmol) and phen (0.0396 g, 0.2 mmol) with a molar ratio of 1:2:2 were dissolved in the distilled water (5 mL), and stired for 25 min, then set in a Teflon-lined autoclave and heating at 160 C for five days. After cooling to the room temperature, yellow block crystals were obtained. Yield: 28.84 mg (77%, on Cd(II) cations). The products were washed by distilled water and dried in air. Elemental analysis (%): Calc. for 1: C, 52.87; H, 3.74; N, 11.21. Found: C, 52.60; H, 3.38; N, 11.01. IR (KBr pellet, (cm-1)): 3428 (s), 3056 (m), 1717 (w), 1576 (s), 1505 (w), 1472 (w),1384 (m), 1353 (s), 1102 (m), 845 (s), 772 (m). 1H NMR (400 MHz, DMSO-d6): delta=8.97 (d, 2H, phen-H2,9), 8.81 (d, 2H, phen-H4,7), 8.40 (s, 1H, -N=CH-NH), 8.22 (d, 2H, H3BIDC aromatic H), 7.98 (d, 2H, phen-H5,6), 7.96 (d, 2H, phen-H3,8) (ppm).

The synthetic route of 10351-75-4 has been constantly updated, and we look forward to future research findings.

A new synthetic route of 10351-75-4

The origin of a common compound about 10351-75-4

A mixture containing Sm2O3 (0.2 mmol), MnSO4*H2O (0.3 mmol), H3bidc (0.6 mmol) and water (10 mL) was sealed in a Teflon-lined stainless steel vessel (23 mL), which was heated at 160 C for 4 days and then cooled to room temperature in 2 days. Colorless rhombic crystals of 1 were obtained and picked out, washed with distilled water and dried in air (Yield: 44.6% based on Sm). Elemental Anal. Calc. C18H24Sm2MnN4O24S2: C, 19.65; H, 2.20; N, 5.09. Found: C, 19.35; H, 2.04; N, 4.95%. IR (KBr, cm-1): 3448.78vs, 1637.12s, 1555.48m, 1504.31m, 1479.17w, 1418.99m,1384.33s, 1098.76m, 642.16m.

Some tips on 10351-75-4

The synthetic route of 10351-75-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 10351-75-4,Some common heterocyclic compound, 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, molecular formula is C9H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of Pb(NO3)2 (0.1 mmol, 33.1 mg), H3bidc (0.1 mmol, 20.6 mg) and phen (0.1 mmol, 18.0 mg) with H2O (8 mL) and methanol (2 mL) were adjusted to pH=7.0 with 1M sodium hydroxide and stirred 1 h. Then they were transferred into a 25 mL Teflon-lined stainless steel container, which were heated at 130 C for 72 h. After cooling to room temperature at a rate of 5 C/h, the block-like crystals of 1 were isolated by washing with distilled water several times and dried in air. The yield was about 40.8 % (based on H3bidc). Elem. Anal. Calcd. for C21H14PbN4O5 (%): C, 41.38; H, 2.32; N, 9.19. Found: C, 41.42; H, 2.39; N, 9.22.

The synthetic route of 10351-75-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Yang; Liu, Ping; Liu, Qing; Pang, Ling-Yan; Ren, Chun-Yan; Wang, Yao-Yu; Inorganic Chemistry Communications; vol. 35; (2013); p. 321 – 325;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem