Category: 1023-01-4

Kumar, G. Santosh published the artcileA copper-catalyzed multi-component reaction accessing fused imidazo-heterocycles via C-H functionalization, Formula: C14H11BrN2, the main research area is pyridone acetophenone copper triflate catalyst microwave irradiation; phenylimidazopyridine preparation multicomponent reaction green chem; thiazole acetophenone copper triflate catalyst microwave irradiation; phenylimidazothiazole preparation multicomponent reaction green chem.

An efficient synthesis of fused imidazo-heterocycles was described using Cu(OTf)2 in [bmim]BF4 by the multi-component reaction of pyridin-2(1H)-one or thiazol/benzo[d]thiazol-2(3H)-ones with O-tosylhydroxyl amine and acetophenones under microwave irradiation The method was very rapid and the product formation occurred via a C-H functionalization/tandem addition-cyclization process. The ionic liquid containing copper triflate was recovered and reused four times.

RSC Advances published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kotla, Siva K. Reddy published the artcileRhodium(III)-catalyzed double C-H activation: a straightforward approach to fused imidazo[1,2-a]pyridines from internal alkynes, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is polycyclic imidazopyridine preparation; rhodium catalyst oxidative coupling imidazopyridine internal alkyne.

The Rh(III)-catalyzed oxidative coupling of 2-arylimidazopyridines with internal alkynes via double C-H activation has been described. This approach provides straightforward access to highly functionalized polycyclic imidazopyridines in good to excellent yields. E.g., in presence of [Cp*RhCl2]2, Cu(OAc)2, and Cs2CO3, oxidative coupling of 2-arylimidazo[1,2-a]pyridine (I) with PhCCPh gave 85% 5,6-diphenylnaphtho[1′,2′:4,5]imidazo[1,2-a]pyridine (II).

Tetrahedron Letters published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bhutia, Zigmee T. published the artcileIodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an “”On-Water”” Platform, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is aryl methyl ketone aminopyridine iodine micellar catalyst cyclization green; imidazopyridine preparation.

In a new and environmentally sustainable approach, a series of 2-arylimidazo[1,2-a]pyridine derivatives were synthesized in aqueous media in the presence of iodine as a catalyst. The reaction proceeded by condensation of various aryl Me ketones with 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good overall yields. Although several of the reactions were efficiently performed “”on water””, the addition of a surfactant, namely, sodium dodecyl sulfate , was found effective in terms of substrate scope and yield enhancement. Both methods were successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The simple exptl. setup, water as “”green”” media, and inexpensive catalyst are some of the merits of this protocol.

ACS Omega published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dabiri, Yasamin published the artcileImidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs, Product Details of C14H11BrN2, the main research area is induced pluripotent stem cell reprogramming efficiency imidazopyridine KDM5 demethylation; Biochemistry; Biological Sciences; Molecular Biology.

Pioneering human induced pluripotent stem cell (iPSC)-based pre-clin. studies have raised safety concerns and pinpointed the need for safer and more efficient approaches to generate and maintain patient-specific iPSCs. One approach is searching for compounds that influence pluripotent stem cell reprogramming using functional screens of known drugs. Our high-throughput screening of drug-like hits showed that imidazopyridines-analogs of zolpidem, a sedative-hypnotic drug-are able to improve reprogramming efficiency and facilitate reprogramming of resistant human primary fibroblasts. The lead compound (O4I3) showed a remarkable OCT4 induction, which at least in part is due to the inhibition of H3K4 demethylase (KDM5, also known as JARID1). Experiments demonstrated that KDM5A, but not its homolog KDM5B, serves as a reprogramming barrier by interfering with the enrichment of H3K4Me3 at the OCT4 promoter. Thus our results introduce a new class of KDM5 chem. inhibitors and provide further insight into the pluripotency-related properties of KDM5 family members.

iScience published new progress about Cadherin CDH1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Product Details of C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem