10111-08-7 Archives - Page 8 of 20 - Imidazoles-derivatives

Pan, Yong team published research in Microporous and Mesoporous Materials in 2021 | 10111-08-7

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Reference of 10111-08-7

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Reference of 10111-08-7.

Pan, Yong;Xie, Rui;Xu, BaoMing;Chen, Chi research published 《 Determination of sorption and diffusion for ethanol through superhydrophobic ZIF/PDMS mixed matrix membrane》, the research content is summarized as follows. The hydrophobicity-hydrophilicity properties of the surface play decisive roles in the resultant separation performance of the membrane, especially the hydrophobicity of mixed matrix membranes (MMMs) for pervaporation recovery of various organic systems from aqueous solution Herein, superhydrophobic Zeolitic Imidazolate Framework-90 (S-ZIF-90) was employed as filler to incorporate into Polydimethylsiloxane (PDMS) to prepare superhydrophobic S-ZIF-90/PDMS MMMs for ethanol permselective pervaporation. The chem. structures and superhydrophobicity properties of the surface of S-ZIF-90 and S-ZIF-90/PDMS MMMs were demonstrated by various characterization techniques. The results showed that S-ZIF-90 particles and S-ZIF-90/PDMS composite membranes were successfully prepared and S-ZIF-90/PDMS MMMs have higher hydrophobicity property as compared to ZIF-90/PDMS MMMs or pure PDMS. Therefore, S-ZIF-90/PDMS MMMs showed more excellent separation performance than ZIF-90/PDMS MMMs or pure PDMS. In particular, S-ZIF-90/PDMS MMMs with 15 wt% S-ZIF-90 loading have a total flux of 1064 g/(m² h) with a maximum separation factor of 14.9 at 40°C for 5 wt% dilute ethanol solution The diffusion coefficients, permeation coefficients, adsorption heat and adsorption entropy of ethanol and water were also calculated by sorption tests, which might provide a method to further determinate the mass transfer mechanism of MMMs in pervaporation process.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Martins-Costa, Marilia T. C. team published research in Chemical Science in 2022 | 10111-08-7

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Martins-Costa, Marilia T. C.;Anglada, Josep M.;Francisco, Joseph S.;Ruiz-Lopez, Manuel F. research published 《 Photosensitization mechanisms at the air-water interface of aqueous aerosols》, the research content is summarized as follows. Photosensitization reactions are believed to provide a key contribution to the overall oxidation chem. of the Earth s atm. Generally, these processes take place on the surface of aqueous aerosols, where organic surfactants accumulate and react, either directly or indirectly, with the activated photosensitizer. However, the mechanisms involved in these important interfacial phenomena are still poorly known. This work sheds light on the reaction mechanisms of the photosensitizer imidazole-2-carboxaldehyde through ab initio (QM/MM) mol. dynamics simulations and high-level ab initio calculations The nature of the lowest excited states of the system (singlets and triplets) is described in detail for the first time in the gas phase, in bulk water, and at the air-water interface, and possible intersystem crossing mechanisms leading to the reactive triplet state are analyzed. Moreover, the reactive triplet state is shown to be unstable at the air-water surface in a pure water aerosol. The combination of this finding with the results obtained for simple surfactant-photosensitizer models, together with exptl. data from the literature, suggests that photosensitization reactions assisted by imidazole-2-carboxaldehyde at the surface of aqueous droplets can only occur in the presence of surfactant species, such as fatty acids, that stabilize the photoactivated triplet at the interface. These findings should help the interpretation of field measurements and the design of new laboratory experiments to better understand atm. photosensitization processes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mas Claret, Eduard team published research in Bioorganic & Medicinal Chemistry in 2020 | 10111-08-7

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Formula: C4H4N2O.

Mas Claret, Eduard;Al Yahyaei, Balqees;Chu, Shuyu;Elliott, Ruan M.;Imperato, Manuel;Lopez, Arnaud;Meira, Lisiane B.;Howlin, Brendan J.;Whelligan, Daniel K. research published 《 An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG)》, the research content is summarized as follows. The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischemic reperfusion or treatment with alkylating agents. A chem. probe inhibitor is required for investigations of the biol. mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

McNulty, James team published research in Bioorganic & Medicinal Chemistry Letters in 2020 | 10111-08-7

HPLC of Formula: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. HPLC of Formula: 10111-08-7.

McNulty, James;Babu Dokuburra, Chanti;D’Aiuto, Leonardo;Demers, Matthew;McClain, Lora;Piazza, Paolo;Williamson, Kelly;Zheng, Wenxiao;Nimgaonkar, Vishwajit L. research published 《 Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies》, the research content is summarized as follows. The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 and three sequential arrays of structural analogs along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mei, Douchao team published research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021 | 10111-08-7

Mei, Douchao;Li, Huan;Liu, Lijia;Jiang, Lichao;Zhang, Chunhong;Wu, Xinrui;Dong, Hongxing;Ma, Fuqiu research published 《 Efficient uranium adsorbent with antimicrobial function: Oxime functionalized ZIF-90》, the research content is summarized as follows. The anti-fouling performance of an adsorbent is important for its application in wastewater, because biol. fouling severely reduces its adsorption capacity. A zeolitic imidazolate framework was synthesized and oxime-functionalized to produce an efficient uranium adsorbent with antimicrobial properties (ZIF-90-OM). Its adsorption performance for U (VI) was studied under different environmental parameters, including pH, initial uranium concentration, competitive ions, ionic strength, temperature, and contact time. Due to its porous structure and the strong chelation of oxime groups with U (VI), ZIF-90-OM showed a very high maximum adsorption capacity for U (VI) of 610 mg/g at pH = 5.0. The adsorption of uranium on ZIF-90-OM correlated well with the Langmuir model and the pseudo-second-order kinetic model. ZIF-90-OM showed high uranium selectivity even in the presence of competing metal ions. Besides, the adsorbent also exhibits good recyclability, the adsorption capacity was maintained after five adsorption/desorption cycles. Furthermore, ZIF-90-OM showed excellent antimicrobial properties against both Gram-neg. Escherichia coli (E. coli) and Gram-pos. Staphylococcus aureus (S. aureus). Our work shows that ZIF-90-OM is an efficient adsorbent for the removal of U (VI) from wastewater because of the presence of oxime groups and its anti-fouling properties. Moreover, due to its antimicrobial properties, ZIF-90-OM can be used to purify water.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mei, Douchao team published research in Journal of Hazardous Materials in 2022 | 10111-08-7

Mei, Douchao;Liu, Lijia;Li, Huan;Wang, Yudan;Ma, Fuqiu;Zhang, Chunhong;Dong, Hongxing research published 《 Efficient uranium adsorbent with antimicrobial function constructed by grafting amidoxime groups on ZIF-90 via malononitrile intermediate》, the research content is summarized as follows. Herein, a dual-function Zeolitic Imidazole Frameworks (ZIFs) ZIF-90 grafted with malononitrile by Knoevenagel reaction and following with an amidoximation reaction to form an efficient U (VI) adsorbent (ZIF-90-AO). The strong chelation power of amidoxime groups (AO) with uranium and ZIF-90s mesoporous structure afforded ZIF-90-AO high maximum uranium adsorption capacity of 468.3 mg/g (pH = 5). In addition, the factors affecting uranium adsorption process were investigated by a batch of adsorption tests under different adsorption conditions. ZIF-90-AO displayed good selectivity to UO²⁺₂ in the solution containing multiple co-existing ions and good regeneration property. More importantly, ZIF-90-AO showed excellent antimicrobial property against both E. coli and S. aureus. Therefore, ZIF-90-AO is a U-adsorbent with great application value for removing U (VI) from wastewater due to the high U (VI) adsorption capacity in weak acid condition and good anti-biofouling properties.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mollick, Samraj team published research in Energy & Environmental Science in 2022 | 10111-08-7

Electric Literature of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Mollick, Samraj;Saurabh, Satyam;More, Yogeshwar D.;Fajal, Sahel;Shirolkar, Mandar M.;Mandal, Writakshi;Ghosh, Sujit K. research published 《 Benchmark uranium extraction from seawater using an ionic macroporous metal-organic framework》, the research content is summarized as follows. Large-scale uranium extraction from seawater (UES) is widely considered as reconciliation to increasing global energy demand and climate change crises. However, an ideal uranium sorbent combining the features of high capacity, excellent selectivity, and ultra-fast kinetics is highly desirable but a long-standing challenge due to the lack of a proper adsorbent. Herein, we adopted a prototypal hybridization strategy to design a rare ionic macroporous metal-organic framework (MOF) decorated with multiple functional groups. The resulting ionic adsorbent captures 99.98% of the uranium in just 120 min (from ∼50 000 to ∼10 ppb) and offers a very large distribution coefficient, KUd > 107 mL g-1, demonstrating a strong affinity towards uranium. Notably, the material harvests 96.3% of uranium simply in 120 min from natural seawater, affording a remarkable enrichment index of 25044 and thereby introducing a new benchmark uranium adsorbent. Moreover, it satisfied the preset target of the UES standard (6 mg g-1) within 2 days and achieved a record uranium uptake capacity of 28.2 mg g-1 from natural seawater only in 25 days, which is a significant breakthrough in UES. The structural evidence from both exptl. and theor. studies confirmed that the formation of favorable chelating motifs into the ionic macropores governs the highly selective recovery of uranium from water.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mowat, Jeffrey team published research in ACS Medicinal Chemistry Letters in 2022 | 10111-08-7

Computed Properties of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Mowat, Jeffrey;Ehrmann, Alexander H. M.;Christian, Sven;Sperl, Carolyn;Menz, Stephan;Guenther, Judith;Hillig, Roman C.;Bauser, Marcus;Schwede, Wolfgang research published 《 Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179》, the research content is summarized as follows. Mitochondria are key regulators of energy supply and cell death. Generation of ATP within mitochondria occurs through oxidative phosphorylation (OXPHOS), a process which utilizes the four complexes (complex I-IV) of the electron transport chain and ATP synthase. Certain oncogenic mutations (e.g., LKB1 or mIDH) can further enhance the reliance of cancer cells on OXPHOS for their energetic requirements, rendering cells sensitive to complex I inhibition and highlighting the potential value of complex I as a therapeutic target. Herein, we describe the discovery of a potent, selective, and species cross-reactive complex I inhibitor. A high-throughput screen of the Bayer compound library followed by hit triaging and initial hit-to-lead activities led to a lead structure which was further optimized in a comprehensive lead optimization campaign. Focusing on balancing potency and metabolic stability, this program resulted in the identification of BAY-179, an excellent in vivo suitable tool with which to probe the biol. relevance of complex I inhibition in cancer indications.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mukherjee, Arpan team published research in Chemistry – An Asian Journal in 2021 | 10111-08-7

Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Mukherjee, Arpan;Koley, Tuhin Subhra;Chakraborty, Ayan;Purkait, Kallol;Mukherjee, Arindam research published 《 Synthesis, Structure and Cytotoxicity of N,N and N,O-Coordinated Ru^II Complexes of 3-Aminobenzoate Schiff Bases against Triple-negative Breast Cancer》, the research content is summarized as follows. Half-sandwich Ru^II complexes, [(YZ)Ru^II(η⁶-arene)(X)]+, (YZ = chelating Schiff base bidentate ligand, X = halide), with N,N and N,O coordination show significant antiproliferative activity against the metastatic triple-neg. breast carcinoma (MDA-MB-231). 3-Aminobenzoic acid or its Me ester is used in all the ligands as an amine component, while varying the aldehyde for N,N and N,O coordination. In the N,N coordinated complex the coordinated halide(X) is varied for enhancing stability in solution (X = Cl, I). Rapid aquation and halide exchange of the pyridine analogs in solution are a major bane towards their antiproliferative activity. Presence of free carboxy group make complexes hydrophilic and reduces toxicity. The imidazolyl 3-aminobenzoate based N,N coordinated complexes display better solution stability and efficient antiproliferative activity (IC₅₀ ca. 2.3-2.5μM) compared to the pyridine based analogs (IC₅₀>100μM) or the N,O coordinated complexes (IC₅₀ ca. 7-10μM). The iodido coordinated complex is resistant towards aquation and halide exchange. The N,O coordinated complexes underwent instantaneous aquation at pH 7.4 generating monoaquated complexes stable for at least 6 h. Binding to 9-ethylguanine (9-EtG) was examined showing propensity to interact with DNA bases. The complexes may kill via apoptosis as displayed from the study of the iodide complex. The change in coordination mode and the aldehyde affected the solution stability, antiproliferative activity and mechanistic pathways. The N,N coordinated complexes exhibit arrest in the G2/M phase while the N,O coordinated showed arrest in the G0/G1 phase.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Longnecker, Emmaline R. team published research in ACS Omega in 2021 | 10111-08-7

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Related Products of 10111-08-7.

Longnecker, Emmaline R.;Metz, Lucy;Miller, Rebecca S.;Berke, Andrew E. research published 《 Probing Liquid-Liquid Phase Separation in Secondary Organic Aerosol Mimicking Solutions Using Articulated Straws》, the research content is summarized as follows. The presence or absence of liquid-liquid phase separation (LLPS) in aerosol particles containing oxidized organic species and inorganic salts affects particle morphol. and influences uptake into, diffusion through, and reactivity within those particles. We report here an accessible method, similar to ice core analyses, using solutions that are relevant for both aerosol chem. systems and aqueous two-phase extraction systems and contain ammonium sulfate and one of eight alcs. (methanol, ethanol, 1-propanol, 2-propanol, 2-butaonol, 3-methyl-2-butanol, 1,2-propanediol, or 1,3-propanediol) frozen in articulated (bendable) straws to probe LLPS. For alcs. with neg. octanol-water partitioning coefficient (KOW) values and O/C ratios ≥0.5, no LLPS occurs, while for alcs. with pos. KOW values and O/C ratios ≤0.33, phase separation always occurs, both findings consistent with observations using different exptl. techniques. When a third species, glyoxal, is added, the glyoxal stays in the aqueous phase, regardless of whether LLPS occurs. When phase separation occurs, the glyoxal forms a strong intermol. interaction with the sulfate ion, red-shifting the ν3(SO₄^2-) peak by 15 cm^-1. These results provide evidence of chem. interactions within phase-separated systems that have implications for understanding chem. reactivity within those, and related, systems.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem