Category: 10111-08-7

10111-08-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10111-08-7, name is Imidazole-2-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 36 triphenylmethylchloride (640mg, 2.3mmol) in 37 dichloromethane (1mL) was added to a mixture of 2-imidazolecarboxadehyde (200mg, 2.1mmol) and 38 potassium carbonate (1.44g, 10.4mmol) in 39 dimethylformamide (1.5mL). The mixture was stirred at 60C overnight and then cooled down to room temperature. The reaction mixture was extracted with ethyl acetate, the combined extracts were dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by preparative thin layer chromatography eluting with 40% ethyl acetate in 40 hexane to provide 11 9 as a white to light-yellow solid in 32% yield. 1H NMR (300MHz, CDCl3) delta 9.23 (s, 1H), 7.38-7.29 (m, 10H), 7.13-7.10 (m, 6H), 7.02 (s, 1H). The 1H NMR data are consistent with those reported in the literature.17

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Reference:
Article; Patanapongpibul, Manee; Zhang, Changde; Chen, Guanglin; Guo, Shanchun; Zhang, Qiang; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong; Bioorganic and Medicinal Chemistry; vol. 26; 16; (2018); p. 4751 – 4760;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

10111-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10111-08-7 as follows.

General procedure: A typical procedure involves, in a round-bottom flask equipped with a refluxcondenser, in which a mixture of 4-hydroxycoumarin (2 mmol), arylaldehyde(1 mmol), PIL catalyst (10 mol%) and 5 mL of ethanol was stirred at 80 C.The reaction was monitored by TLC. After completion of the reaction, a solidproduct is obtained which is filtered and recrystallized with ethanol(Scheme 2).

According to the analysis of related databases, Imidazole-2-carboxaldehyde, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patil, Sandip K.; Awale, Deepak V.; Vadiyar, Madagonda M.; Patil, Suryakant A.; Bhise, Sagar C.; Kolekar, Sanjay S.; Research on Chemical Intermediates; vol. 43; 10; (2017); p. 5365 – 5376;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem