Category: 10111-08-7

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Electric Literature of 10111-08-7.

Xu, Yu;Zhang, Xiu-Juan;Li, Wen-Bo;Wang, Xing-Rong;Wang, Shuai;Qiao, Xue-Peng;Chen, Shi-Wu research published 《 Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors》, the research content is summarized as follows. A series of indole-2-one derivatives I (R¹ = cyclopropyl, cyclopentyl, 4,5-dihydro-1H-imidazol-2-yl, etc.; R² = H, Me, cyclopropyl, furan-2-yl; R³ = 4-methoxyphenyl, 2,5-difluorophenyl, naphthalen-1-yl, etc.; R¹R² = -(CH₂)₃-, -(CH₂)₅-) and II (R⁴ = 2-methoxyphenyl, cyclohexyl) through scaffold hopping drug design has been designed and synthesized. Most of the compounds showed potent BRD4 inhibitory activities and anti-proliferation activities in cancer cell lines. Especially, compound I (R¹ R² = -(CH₂)₃-; R³ = 2-methoxyphenyl) (II) exhibited excellent BRD4 inhibitory activities (BD1 IC₅₀ = 19 nM, BD2 IC₅₀ = 28 nM) and anti-proliferation potency with IC₅₀ values of 4.75μM and 1.35μM in HT-29 and HL-60 cells, resp. Addnl., docking studies showed that the hydrophobic pocket next to KAc region and WPF shelf were critical to the activity of the compound Compound II could arrest the cell-cycle progression of HT-29 cells into the G1 phase and reduce the expression of c-Myc. Moreover, compound II exhibited favorable oral pharmacokinetic properties. All the results demonstrated that compound II was a potent BRD4 inhibitor and had merely potential for colon cancer treatment.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Electric Literature of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Category: imidazoles-derivatives.

Xue, Lei;Zhang, Aiai;Wu, Jinfang;Wang, Qi;Liu, Yang;Zhao, Yuansong;Liu, Shangpeng;Liu, Ze;Li, Ping;Zeng, Shanghong research published 《 Surface modification and reconstruction of ZnO hollow microspheres for selective electroreduction of CO₂ to CO》, the research content is summarized as follows. Surface chem. can be modified by introducing another component on the surface of catalyst due to the regulation of configuration and electronic properties. Herein, the nanostructured ZnO hollow microspheres were fabricated for selective CO₂ reduction to CO. The addition of CuO weakens the strength of adjacent Zn-O bond and improves the formation of more zero-valence Zn. Small CuO entities can provide the active sites for CO₂ adsorption, and the presence of surface defects due to Zn²⁺ reduction could enhance initial dissociation from CO₂ to CO. More interestingly, the 3CuO/ZnO catalyst underwent reconstruction during electrocatalysis, and multi-shelled hollow spheres evolved into a thin flaky structure. The extended surface area of flaky morphol. enhances the catalytic stability despite the occurrence of ZnO reduction This study highlights the importance of surface modification for CO₂ selective reduction to CO but also provides some insights on reconstruction during electrochem. reduction of CO₂.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Yadav, Manoj Kumar;Pokhrel, Shanta;Yadav, Paras Nath research published 《 Novel chitosan derivatives of 2-imidazolecarboxaldehyde and 2-thiophenecarboxaldehyde and their antibacterial activity》, the research content is summarized as follows. Chitosan was synthesized from chitin; extracted from prawn shells’ powder via deacetylation and physicochem. properties were studied. Novel chitosan derivatives of 2-imidazolecarboxaldehyde and 2-thiophenecarboxaldehyde were synthesized by refluxing equimolar quantities of resp. aldehyde with chitosan. These functionalized chitosan derivatives were characterized by Fourier transform IR (FTIR), ¹³C-NMR (¹³C-NMR) spectroscopy, elemental anal., X-ray diffraction (XRD), thermogravimetric anal. (TGA) and DTA (DTA) and their antibacterial activity was explored. Chitosan derivative of 2-thiophenecarboxaldehyde was found active against Escherichia coli.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Formula: C4H4N2O.

Yang, Yi;Csakai, Adam;Jiang, Shuangshuang;Smith, Christina;Tanji, Hiromi;Huang, Jian;Jones, Torey;Sakaniwa, Kentaro;Broadwell, Lindsey;Shi, Chengrui;Soti, Subada;Ohto, Umeharu;Fang, Yaohui;Shen, Shu;Deng, Fei;Shimizu, Toshiyuki;Yin, Hang research published 《 Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists》, the research content is summarized as follows. Small-mol. modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clin. uses are limited because they can invoke an uncontrolled, global inflammatory response. The efforts described herein culminate in the fortuitous discovery of a tetrasubstituted imidazole CU-CPD107 which inhibits R848-induced TLR8 signaling. In stark contrast, CU-CPD107 shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling. CU-CPD107′s unique, dichotomous behavior sheds light on a way to approach TLR agonists. CU-CPD107 offers the opportunity to avoid the undesired, global inflammation side effects that have rendered imidazoquinolines clin. irrelevant, providing an insight for the development of antiviral drugs.

Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Safety of 1H-Imidazole-2-carbaldehyde.

Yoo, Miri;Koh, Dongsoo research published 《 Diethyl 4-(1H-imidazol-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate》, the research content is summarized as follows. In the title compound, C₁₆H₂₁N₃O₄, the 1,4-dihydropyridine ring adopts a flattened boat conformation, with the imidazole substituent in an axial orientation [dihedral angle between ring planes = 82.9 (6)°]. In the crystal structure, pairs of N-H···O and N-H···N hydrogen bonds with graph-set notation R²₂(14) connect the mols. into chains running along the c-axis direction.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Safety of 1H-Imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Computed Properties of 10111-08-7.

Yoshida, Shuhei;Uehara, Shota;Kondo, Noriyasu;Takahashi, Yu;Yamamoto, Shiho;Kameda, Atsushi;Kawagoe, Soichiro;Inoue, Naoko;Yamada, Masami;Yoshimura, Norito;Tachibana, Yuki research published 《 Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides》, the research content is summarized as follows. Recent technol. innovations have led to the development of methods for the rapid identification of high-affinity macrocyclic peptides for a wide range of targets; however, it is still challenging to achieve the desired activity and membrane permeability at the same time. Here, we propose a novel small mol. lead discovery strategy, ′′Peptide-to-Small Mol.′′, which is a combination of rapid identification of high-affinity macrocyclic peptides via peptide display screening followed by pharmacophore-guided de novo design of small mols., and demonstrate the applicability using nicotinamide N-methyltransferase (NNMT) as a target. Affinity selection by peptide display technol. identified macrocyclic peptide 1 that exhibited good enzymic inhibitory activity but no cell-based activity. Thereafter, a peptide pharmacophore-guided de novo design and further structure-based optimization resulted in highly potent and cell-active small mol. 14 (cell-free IC₅₀ = 0.0011 μM, cell-based IC₅₀ = 0.40 μM), indicating that this strategy could be a new option for drug discovery.

Computed Properties of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Related Products of 10111-08-7.

You, Bo;Li, Siyang;Tsona, Narcisse T.;Li, Jianlong;Xu, Li;Yang, Zhaomin;Cheng, Shumin;Chen, Qingcai;George, Christian;Ge, Maofa;Du, Lin research published 《 Environmental Processing of Short-Chain Fatty Alcohols Induced by Photosensitized Chemistry of Brown Carbons》, the research content is summarized as follows. Fatty alcs. are known surfactants ubiquitous in the environment. They affect physicochem. and optical properties of aerosols and air/water interfaces; however, little is known about their photochem. Brown carbon (BrC) as photosensitizer, may initiate photochem. reactions of such non-photoactive surfactants. BrC was obtained by evaporating methylglyoxal/(NH₄)₂SO₄ or methylglyoxal/glycine (Gly) mixtures The BrC photo-sensitization ability was evidenced by its reaction with 1-octanol under UV irradiation measured by attenuated total reflection Fourier transform IR spectrometry, a surface-sensitive technique. Condensed phase products were determined by gas chromatog./mass spectrometry. A series of functionalized, unsaturated compounds were formed by a photo-sensitized reaction; more highly oxygenated compounds appeared after a long illumination time. This process contributed to formation of reactive volatile and semi-volatile organic compounds and could also trigger secondary chem. The reaction was probably initiated by electronically excited BrC upon exposure to UV radiation. A possible mechanism for fatty alcs. photo-sensitized degradation is proposed. It was also observed that BrC was easily photo-bleached; thus, it has a limited effect on radiative forcing. However, BrC can play an important role in aerosol and air/water interfaces.

Related Products of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Computed Properties of 10111-08-7.

Yuan, Hui;Wu, Yuanfeng;Pan, Xiaomei;Gao, Lijing;Xiao, Guomin research published 《 Pyridyl Ionic Liquid Functionalized ZIF-90 for Catalytic Conversion of CO₂ into Cyclic Carbonates》, the research content is summarized as follows. The aim of this work was to study the enchanted catalytic activity of 3 ionic liquids functionalized ZIF-90 for CO₂ cycloaddition Characterizations such as XRD, FTIR, SEM, XPS, BET, TG and CO₂/NH₃-TPD were adopted to systematically study the structure and properties of functionalized catalysts. When functionalized by [1-aminoethyl-pyridinium]Br (ZIF-90-IL-1), ZIF-90 possesses the highest catalytic activity among the 3 catalysts, which was consistent with the results of CO₂/NH₃-TPD characterizations. The reaction was carried out under the conditions of a catalyst addition amount of 1.0%, an initial pressure of 25 bar and a temperature of 90° and 96.27% of propylene oxide (PO) conversion and 94.51% of propylene carbonate (PC) yield were obtained when the reaction was lasted to 8 h. ZIF-90-IL-1 was used in the coupling reaction of various epoxides with CO₂ under the same reaction conditions, and when allyl-glycidyl ether (AGE) was used as a substrate, the yield was the highest. One-pot catalytic conversion of CO₂ into cyclic carbonate over pyridyl ionic liquid functionalized ZIF-90.[graphic not available: see fulltext].

Computed Properties of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. COA of Formula: C4H4N2O.

Woods, Ephraim;Harris, Oliver T.;Leiter, William E.;Burner, Nora E.;Ofosuhene, Pomaa;Krez, Alexandra;Hilton, Mark A.;Burke, Kathleen A. research published 《 Lifetime of Triplet Photosensitizers in Aerosol Using Time-Resolved Photoelectric Activity》, the research content is summarized as follows. Time-resolved photoelec. activity of aerosol (TPEAA) experiments measure the kinetics of photochem. initiated reactions near the surface of aerosol particles. In the demonstration presented here, TPEAA experiments monitor the evolution of excited triplet states, which are key intermediates in the photochem. formation of secondary organic aerosol (SOA). One example is the decay of the triplet excited state of imidazole-2-carboxaldehyde (IC) in aqueous NaCl aerosol particles. The decay of the triplet IC shows two distinct timescales, indicative of two populations of IC in the particles: aqueous and pure IC. The lifetime in the pure-IC phase is less than 20 ns, and the lifetime associated with aqueous IC is limited by reaction with chloride ions (k = 5.6 x 10⁵ M^-1 s^-1). The results demonstrate how phase separation in aerosol particles can control reaction pathways and kinetics. In another example, TPEAA monitors the decay of the triplet anthraquinone-2-sulfonate (AQ2S) anion in aqueous NaCl aerosol. The AQ2S triplet reacts with water (k’ = 8.7 x 10⁶ s^-1) to produce adduct species. In this case, tuning the wavelength of the photoemission laser permits the preferential observation of the triplet or a combination of the AQ2S triplet and the water adduct. These results bridge a gap between aerosol phase measurements, which are normally steady-state and bulk-phase transient absorption measurements, which typically probe homogeneous phases.

COA of Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Quality Control of 10111-08-7.

Wu, Shuai;Sun, Zhaowei;Peng, Ying;Han, Yiwei;Li, Jinlong;Zhu, Sha;Yin, Yongmei;Li, Genxi research published 《 Peptide-functionalized metal-organic framework nanocomposite for ultrasensitive detection of secreted protein acidic and rich in cysteine with practical application》, the research content is summarized as follows. In this work, we have prepared peptide-functionalized metal-organic frameworks (MOFs) as signal-amplifying tags for the detection of secreted protein acidic and rich in cysteine (SPARC). Furthermore, enzyme-MOF nanocomposites are fabricated via a coprecipitation strategy between horse radish peroxidase (HRP) and ZIF-90, where ZIF-90 is used as a protective support for HRP immobilization. Meanwhile, the peptide sequence has been designed as SPARC-binding peptide, which imparts biorecognition functionality to HRP@ZIF-90 for performing a colorimetric sensor. Therefore, during the test, HRP mols. can be quickly released from nanocomposites by acidic condition to catalyze chromogenic reaction, enabling the ultrasensitive detection of SPARC with a low detection limit of 30 fg/mL. Moreover, the content of SPARC in colon cancer tissues with different degrees of differentiation can be determined with this sensor, demonstrating that the expression of SPARC is closely related to the occurrence, invasion and metastasis of human colon cancer. These results may show the potential applications of this biosensor in SPARC fundamental research as well as clin. diagnosis in the future.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Quality Control of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem