Category: 10111-08-7

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Name: 1H-Imidazole-2-carbaldehyde.

Ding, Zhongpeng;Li, Feifei;Zhong, Changjiang;Li, Feng;Liu, Yuqian;Wang, Shixiao;Zhao, Jianchun;Li, Wenbao research published 《 Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer》, the research content is summarized as follows. To developed more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives (I) [R = H, Me, cyclopropyl, iso-Pr, tert-butyl; X = O, CO] and (II) [R¹= 2-furyl, cyclohexyl, 2-benzoimidazolyl, etc.; X = O; R¹= 5-methyl-2-furyl, 5-methoxymethyl-2-furyl; X = CO] were summarized and analyzed. The further modifications were performed the tert-Bu moiety or C-ring of imidazole-type derivatives to build a library of mols. through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds (II) [R¹= 5-methoxymethyl-2-furyl, X = O] (IC₅₀= 14.0 nM, NCI-H460) and [R¹= 5-methoxymethyl-2-furyl, X = CO] (IC₅₀= 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-Me or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-Bu moiety at the 5-position of imidazole was essential for the activity of such compounds Immunofluorescence assay indicated that compounds II [R¹= 5-methoxymethyl-2-furyl, X = O, CO] could efficiently inhibited microtubule polymerization Overall, the novel furan-diketopiperazine-type derivatives I and II could be considered as a potential scaffold for the development of anti-cancer drugs.

Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Product Details of C4H4N2O.

Dong, Ji;Huang, Shi-sheng;Hao, Ya-nan;Wang, Zi-wen;Liu, Yu-xiu;Li, Yong-qiang;Wang, Qing-min research published 《 Marine-natural-products for biocides development: first discovery of meridianin alkaloids as antiviral and anti-phytopathogenic-fungus agents》, the research content is summarized as follows. BACKGROUND : Food is an important strategic material related to national economy and people’s livelihood. In this work, meridianin alkaloids were selected as the parent structure. A series of meridianin alkaloid analogs were rationally designed, synthesized and evaluated for their antiviral activities and fungicidal activities. RESULT : These compounds were found to have good antiviral and fungicidal activities for the first time. The structure-activity relationship (SAR) research revealed that introducing bromine atom at the 5-position of indole ring is beneficial to antiviral activity, but introducing methoxy group is not conducive. Introducing bromine atom at the 6-position of indole ring or nitrogen atom at the 7-position of the indole ring resulted in lower antiviral activity. Most of the meridianin derivatives showed higher anti-TMV activities at 500μg mL^-1 than Ribavirin, especially for compounds 6c, 8a and 10a. All of the compounds also displayed broad spectrum fungicidal activities against 14 kinds of phytopathogenic fungi at 50μg mL^-1. CONCLUSION : Compound 6c with relatively simple structure and excellent antiviral activity, which is similar to that of Ningnanmycin, emerged as novel anti-TMV lead compound Compound 5d with broad spectrum and high effect fungicidal activity emerged as a new fungicidal lead compound Current research lays a solid foundation for the application of meridianin alkaloids in crop protection.

Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Category: imidazoles-derivatives.

Du, Xiaoyu;Li, Mengwen;Du, Man;Shen, Ao;Hao, Xiaohui;Yuan, Jiaxin;Ma, Shufeng;Zhao, Yongwei;Hou, Lala;Li, Ziqi;Yang, Yunxu research published 《 A one-pot strategic construction of functionalized nanomaterial ZIF-90-Rhn for stepwise detection and capturing of Ag⁺ and formaldehyde from an aqueous solution》, the research content is summarized as follows. In this work, a new functionalized nanomaterial, ZIF-90-Rhn, was designed, synthesized and characterized. The synthesis was performed by one-pot strategic construction, post-modification and pre-modification synthesis methods. After encapsulating cyanine dye, Cy-N, into ZIF-90-Rhn, a multi-functional complex of ZIF-90-Rhn@Cy-N was successfully obtained and could be used to detect Ag⁺ in dual-signals (fluorescence signal and visual color signal) by forming an intermedial product of ZIF-90-Rhn@Ag⁺/Cy-N in an aqueous solution Subsequently, the intermediate product ZIF-90-Rhn@Ag⁺/Cy-N could detect formaldehyde (FA) via a stepwise redox recognition reaction through dual-signals. A smartphone portable online detection platform for Ag⁺ and FA using Bluetooth for the color changes under visible light was not realized, and the results are consistent with the fluorescence sensing assay results. Moreover, a chitosan non-woven fabric coated with ZIF-90-Rhn@Cy-N on its surface was considered to evaluate its efficient capturing and removing effects on Ag⁺ and FA in a stepwise actual procedure in water.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Synthetic Route of 10111-08-7.

Eckhardt, Andre K. research published 《 Spectroscopic evidence for 1,2-diiminoethane – a key intermediate in imidazole synthesis》, the research content is summarized as follows. Simple imines and diimines are common building blocks in organic synthesis, but the compound class is spectroscopically not well characterized. Herein we report the formation of the simplest diimine, namely 1,2-diiminoethane, as well as spectroscopic characterization by cryogenic matrix isolation IR and UV/Vis spectroscopy. Three conformers of 1,2-diiminoethane form after UV irradiation of 1,2-diazidoethane by N₂ extrusion at 3 K in solid argon and can be photochem. interconverted. In a matrix isolation pyrolysis experiment at 600°C with 1,2-diazidoethane as the starting material we observe hydrogen cyanide and formaldimine as the main decomposition products. All exptl. findings are supported by deuterium labeling experiments and B3LYP/6-311++G(2d,2p) calculations Irradiation of 1,2-diazidoethane in aqueous solution leads to the formation of imidazoles as indicated by NMR spectroscopy and GC-MS anal. Our results underline the key role of diimines as building blocks in N-heterocyclic chem.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Synthetic Route of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives.

Dende, Satheesh Kumar;Korupolu, Raghu Babu;Leleti, Krishnakanth Reddy research published 《 Design and Synthesis of Sulfonamide-Attached 2-(Isoxazol-3-yl)-1H-imidazoles as Anticancer Agents》, the research content is summarized as follows. Library of 2-(isoxazol-3-yl)-1H-imidazole sulfonamides I [R = H, 4-Me, 3,4-di-Cl, etc.] were synthesized and structures were confirmed by ¹HNMR, ¹³CNMR and mass spectral anal. Further these compounds I were tested for their anticancer activity against four human cancer cell lines, such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as pos. control. Among them, compounds I [R = 2,3,5-tri-MeO, 3,5-di-Cl, 4-MeO, 4-Cl, 4-CN, 4-NO₂, 3-NO₂] showed more potent anticancer activity against human cancer cell lines.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Devlin, Rory;Jones, David J.;McGlacken, Gerard P. research published 《 One-Pot, Tandem Wittig Hydrogenation: Formal C(sp³)-C(sp³) Bond Formation with Extensive Scope》, the research content is summarized as follows. A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp³)-C(sp³) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodol. is demonstrated in the synthesis of lapatinib analogs and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Name: 1H-Imidazole-2-carbaldehyde.

Ding, Zhongpeng;Li, Feifei;Zhong, Changjiang;Li, Feng;Liu, Yuqian;Wang, Shixiao;Zhao, Jianchun;Li, Wenbao research published 《 Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer》, the research content is summarized as follows. To developed more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives (I) [R = H, Me, cyclopropyl, iso-Pr, tert-butyl; X = O, CO] and (II) [R¹= 2-furyl, cyclohexyl, 2-benzoimidazolyl, etc.; X = O; R¹= 5-methyl-2-furyl, 5-methoxymethyl-2-furyl; X = CO] were summarized and analyzed. The further modifications were performed the tert-Bu moiety or C-ring of imidazole-type derivatives to build a library of mols. through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds (II) [R¹= 5-methoxymethyl-2-furyl, X = O] (IC₅₀= 14.0 nM, NCI-H460) and [R¹= 5-methoxymethyl-2-furyl, X = CO] (IC₅₀= 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-Me or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-Bu moiety at the 5-position of imidazole was essential for the activity of such compounds Immunofluorescence assay indicated that compounds II [R¹= 5-methoxymethyl-2-furyl, X = O, CO] could efficiently inhibited microtubule polymerization Overall, the novel furan-diketopiperazine-type derivatives I and II could be considered as a potential scaffold for the development of anti-cancer drugs.

Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Product Details of C4H4N2O.

Dong, Ji;Huang, Shi-sheng;Hao, Ya-nan;Wang, Zi-wen;Liu, Yu-xiu;Li, Yong-qiang;Wang, Qing-min research published 《 Marine-natural-products for biocides development: first discovery of meridianin alkaloids as antiviral and anti-phytopathogenic-fungus agents》, the research content is summarized as follows. BACKGROUND : Food is an important strategic material related to national economy and people’s livelihood. In this work, meridianin alkaloids were selected as the parent structure. A series of meridianin alkaloid analogs were rationally designed, synthesized and evaluated for their antiviral activities and fungicidal activities. RESULT : These compounds were found to have good antiviral and fungicidal activities for the first time. The structure-activity relationship (SAR) research revealed that introducing bromine atom at the 5-position of indole ring is beneficial to antiviral activity, but introducing methoxy group is not conducive. Introducing bromine atom at the 6-position of indole ring or nitrogen atom at the 7-position of the indole ring resulted in lower antiviral activity. Most of the meridianin derivatives showed higher anti-TMV activities at 500μg mL^-1 than Ribavirin, especially for compounds 6c, 8a and 10a. All of the compounds also displayed broad spectrum fungicidal activities against 14 kinds of phytopathogenic fungi at 50μg mL^-1. CONCLUSION : Compound 6c with relatively simple structure and excellent antiviral activity, which is similar to that of Ningnanmycin, emerged as novel anti-TMV lead compound Compound 5d with broad spectrum and high effect fungicidal activity emerged as a new fungicidal lead compound Current research lays a solid foundation for the application of meridianin alkaloids in crop protection.

Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Category: imidazoles-derivatives.

Du, Xiaoyu;Li, Mengwen;Du, Man;Shen, Ao;Hao, Xiaohui;Yuan, Jiaxin;Ma, Shufeng;Zhao, Yongwei;Hou, Lala;Li, Ziqi;Yang, Yunxu research published 《 A one-pot strategic construction of functionalized nanomaterial ZIF-90-Rhn for stepwise detection and capturing of Ag⁺ and formaldehyde from an aqueous solution》, the research content is summarized as follows. In this work, a new functionalized nanomaterial, ZIF-90-Rhn, was designed, synthesized and characterized. The synthesis was performed by one-pot strategic construction, post-modification and pre-modification synthesis methods. After encapsulating cyanine dye, Cy-N, into ZIF-90-Rhn, a multi-functional complex of ZIF-90-Rhn@Cy-N was successfully obtained and could be used to detect Ag⁺ in dual-signals (fluorescence signal and visual color signal) by forming an intermedial product of ZIF-90-Rhn@Ag⁺/Cy-N in an aqueous solution Subsequently, the intermediate product ZIF-90-Rhn@Ag⁺/Cy-N could detect formaldehyde (FA) via a stepwise redox recognition reaction through dual-signals. A smartphone portable online detection platform for Ag⁺ and FA using Bluetooth for the color changes under visible light was not realized, and the results are consistent with the fluorescence sensing assay results. Moreover, a chitosan non-woven fabric coated with ZIF-90-Rhn@Cy-N on its surface was considered to evaluate its efficient capturing and removing effects on Ag⁺ and FA in a stepwise actual procedure in water.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Synthetic Route of 10111-08-7.

Eckhardt, Andre K. research published 《 Spectroscopic evidence for 1,2-diiminoethane – a key intermediate in imidazole synthesis》, the research content is summarized as follows. Simple imines and diimines are common building blocks in organic synthesis, but the compound class is spectroscopically not well characterized. Herein we report the formation of the simplest diimine, namely 1,2-diiminoethane, as well as spectroscopic characterization by cryogenic matrix isolation IR and UV/Vis spectroscopy. Three conformers of 1,2-diiminoethane form after UV irradiation of 1,2-diazidoethane by N₂ extrusion at 3 K in solid argon and can be photochem. interconverted. In a matrix isolation pyrolysis experiment at 600°C with 1,2-diazidoethane as the starting material we observe hydrogen cyanide and formaldimine as the main decomposition products. All exptl. findings are supported by deuterium labeling experiments and B3LYP/6-311++G(2d,2p) calculations Irradiation of 1,2-diazidoethane in aqueous solution leads to the formation of imidazoles as indicated by NMR spectroscopy and GC-MS anal. Our results underline the key role of diimines as building blocks in N-heterocyclic chem.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Synthetic Route of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem