Category: 101018-70-6

Spectral and quantum-chemical study of properties and structure of 5-hydroxybenzimidazole was written by Zaitsev, B. E.;Gaevskaya, A. E.;Kuznetsov, S. L.;Kuznetsov, Yu. V.;Stolyarova, L. G.;Smirnov, L. D.. And the article was included in Izvestiya Akademi Nauk, Seriya Khimicheskaya in 1992.HPLC of Formula: 101018-70-6 The following contents are mentioned in the article:

The heats of formation of six tautomers of the title compound (I) and their anionic and cationic forms as well as energetic, electronic, and structural characteristics of neutral, protonated, and deprotonated tautomers have been calculated by the MNDO method. According to IR spectra I exists in the hydroxy form as two tautomers in the crystal and in CCl₄ or CH₃CN solution Marked differences were noted in the electronic absorption spectra in acidic media of benzimidazoles with a benzene ring at C-2 as compared with those having alkyl substituents at this position. Spectral characteristics are given to distinguish mono- and dianionic forms of I derivatives This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6HPLC of Formula: 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study of 5(6)-hydroxybenzimidazole aminomethylation was written by Smirnov, L. D.;Kuznetsov, Yu. V.;Stolyarova, L. G.;Lezina, V. P.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1985.Reference of 101018-70-6 The following contents are mentioned in the article:

Treating benzimidazole I (R = Me, R¹ = R² = H) with N-(methoxymethyl)piperidine, -morpholine, and N,N,N‘,N‘-tetramethylmethylenediamine in alc. gave 92.7, 88.7, and 65.4% aminomethylated derivatives I (R = Me, R¹ = piperidinomethyl, morpholinomethyl, Me₂NCH₂; R² = H). Treating I (R-R² = H) with piperidine and paraformaldehyde under Mannich reaction conditions gave I (R = H, R¹ = piperidinomethyl, R² = H, piperidinomethyl). Analogously obtained was I (R = H, R¹ = R² = Me₂NCH₂). This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Reference of 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new class of plant growth regulators, aminomethyl derivatives of 2-methyl-5-hydroxybenzimidazole was written by Apasheva, L. M.;Kuznetsov, Yu. V.;Poltorak, K. D.;Smirnov, L. D.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya in 1987.Related Products of 101018-70-6 The following contents are mentioned in the article:

Four heterocyclic phenolic antioxidants I (R = H, piperidinomethylene, II, or CH₂NMe₂) showed cytokinin activity (stimulation of germination in millet and corn seed weakened by prolonged storage) exceeding benzimidazole (III). At 1, 0.1, 1, and 1 mg/L, resp., I stimulated root growth in corn seedlings by 27.4, 26.5, 9.9, and 54.4%, resp., vs. 8.1% for III, and the growth of aerial parts by 19.7, 8.8, and 57.3, and 133%, resp., vs. 35.6% for III. I acted by stimulating extension growth of cells of corn root tips. I (R = CH₂NMe₂) at 1 mg/L increased total chlorophyll and chlorophyll a of corn leaves by 29 and 36%, resp., and at 10 mg/L stimulated shoot formation by Elodea by 3-fold. I (R = piperidinomethylene) increased the length of Elodea shoots by 80%. I were synthesized according to L. D. Smirnov et al. (1983). This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Related Products of 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design was written by Sanders, Marijn P. A.;Roumen, Luc;van der Horst, Eelke;Lane, J. Robert;Vischer, Henry F.;van Offenbeek, Jody;de Vries, Henk;Verhoeven, Stefan;Chow, Ken Y.;Verkaar, Folkert;Beukers, Margot W.;McGuire, Ross;Leurs, Rob;Ijzerman, Adriaan P.;de Vlieg, Jacob;de Esch, Iwan J. P.;Zaman, Guido J. R.;Klomp, Jan P. G.;Bender, Andreas;de Graaf, Chris. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 101018-70-6 The following contents are mentioned in the article:

We present the systematic prospective evaluation of a protein-based and a ligand-based virtual screening platform against a set of three G-protein-coupled receptors (GPCRs): the 尾-2 adrenoreceptor (ADRB2), the adenosine A_2A receptor (AA2AR), and the sphingosine 1-phosphate receptor (S1PR1). Novel bioactive compounds were identified using a consensus scoring procedure combining ligand-based (frequent substructure ranking) and structure-based (Snooker) tools, and all 900 selected compounds were screened against all three receptors. A striking number of ligands showed affinity/activity for GPCRs other than the intended target, which could be partly attributed to the fuzziness and overlap of protein-based pharmacophore models. Surprisingly, the phosphodiesterase 5 (PDE5) inhibitor sildenafil was found to possess submicromolar affinity for AA2AR. Overall, this is one of the first published prospective chemogenomics studies that demonstrate the identification of novel cross-pharmacol. between unrelated protein targets. The lessons learned from this study can be used to guide future virtual ligand design efforts. This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Recommanded Product: 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem