Category: 1008361-65-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7BrN2O

Step 3: To a stirred mixture of DMF (3 mL) and NaH (60% in mineral oil, 67 mg, 1.6 mmol) at 0 C under argonwas added 5-bromo-6-methoxy-1H-benzo[d]imidazole (346 mg, 1.5 mmol) from Step 2 of this Example in one portion.The mixture was stirred for 5 min at 0 C. A solution of 6-(chloromethyl)-2-(methylthio)benzo[d]thiazole (500 mg, 2.2mmol) from Step 4 of Example 36 in DMF (3 mL) was added dropwise. The mixture was stirred at 0 C for 1 h, thenallowed to warm slowly to rt and stirred for 6 h. The mixture was then partitioned between EtOAc (100 mL) and water(50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was purified by silica gel flash chromatography eluting with 100% EtOAc to afford thetwo regioisomers: Regioisomer 1; 6-((5-bromo-6-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole(127 mg, 20%). The structure was confirmed by comparison with NMR from the regiospecific synthesis of thesame compound described in Step 3 of Example 41. 1H NMR (300 MHz, CDCl3) delta 8.02 (s, 1H), 7.78 – 7.91 (m, 2H),7.47 (s, 1H), 7.25 (m, 1H), 6.70 (s, 1H), 5.43 (s, 2H), 3.82 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.Regioisomer 2; 6-((6-bromo-5-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole (81 mg, 13%).1H NMR (300 MHz, CDCl3) delta 7.92 (s, 1H), 7.84 (d, J = 8.5 Hz, 1H), 7.48 (m, 2H), 7.34 (s, 1H), 7.25 (m, 1H), 5.40 (s,2H), 3.94 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.

The synthetic route of 1008361-65-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1008361-65-6, Product Details of 1008361-65-6

Compound 5-bromo-6-methoxy-1H-benzimidazole 60d (430.0 mg, 1.9 mmol), triethylamine (383.0 mg,3.8 mmol) and 4-dimethylaminopyridine (23.0 mg, 0.2 mmol)With tetrahydrofuran (15.0 mL)After mixing, di-tert-butyl dicarbonate (585.0 mg, 2.9 mmol) was added at room temperature, and the reaction was carried out at 45 C for 12 hours.The reaction solution was diluted with methylene chloride (100 mL) and washed with brine. The organic phase is dried over anhydrous sodium sulfate and filtered to dissolve to give a mixture of 1-t-butoxy acyl-5-Bromo-6-methoxy-benzimidazole 60e and 3-tert-butoxycarbonyl-5-bromo-6-methoxy-benzimidazole 61e (450.0 mg,1.4 mmol, white solid), yield 73%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-6-methoxy-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem