Category: 10040-98-9

Reference of 10040-98-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10040-98-9 as follows.

The compound of formula 6-3 (methyl4-((5-(piperidin-4-yl)- I H-pyrrolo[2,3-b]pyridin- I -yl)methyl)benzoate) (0.100 g, 0.286 mmol), 4-(1H-imidazol-1-yl)benzaldehyde (0.074 g, 0.429 mmol), and sodium triacetoxyborohydride (0.09 1 g, 0.429 mmol) were dissolved in methylene chloride (3 mL) at room temperature, and the solution was stirred at the same temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with methylene chloride. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, filtered, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (SiO 2, 12 g cartridge; methanol I methylene chloride = from 0% to 10%) to afford the desired compound of formula 12-2 (0.077 g, 52.9%) as a yellow liquid.

According to the analysis of related databases, 10040-98-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10040-98-9, COA of Formula: C10H8N2O

General procedure: A mixture of azolyl ketone (1a/1b) (1 mmol) and aryloxy benzaldehyde (2a-f) (1 mmol) were dissolved in 10% NaOH-EtOH (5 mL), it was stirred at room temperature for 9-10 h. After completion, 5 mL water was added to the reaction mixture. The separated solid compound was filtered and washed with water. It was purified by crystallization with methanol/chloroform or basic alumina column chromatography to give the desired compounds (3-13).The compounds (16-31) were prepared by the reaction of their corresponding aldehyde and ketone partners.

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Reference of 10040-98-9, A common heterocyclic compound, 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, molecular formula is C10H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of malonitrile (60.0 mg, 0.9 mmol) and 4-(1H-imidazol-1-yl)benzaldehyde (155.0 mg, 0.9 mmol) in anhydrous ethanol ( 4.0 mL) was charged with N-methylmorpholine (0.1 mL, 0.9 mmol) for 2 minutes. To the mixture was added 1-methyl-3-(pyrazin-2-yl)-1H- pyrazol-5(4H)-one (159.0 mg, 0.9 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and off white solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 23 as an off white solid (340 mg, 95%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 8.98 (s, 1H), 8.50-8.42 (m, 2H), 8.14 (s, 1H), 7.63 (s, 1H), 7.45 (d, J = 8.4 Hz, 2H), 7.28 (d, J = 8.4 Hz, 2H), 7.05 (s, 1H), 5.08 (s, 1H), 3.85 (s, 3H). MS (ESI): Calcd for C21H16N8O: 396, found: 397 (M+H)+.

The synthetic route of 10040-98-9 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10040-98-9 as follows. category: imidazoles-derivatives

General procedure: A mixture of azolyl ketone (1a/1b) (1 mmol) and aryloxy benzaldehyde (2a-f) (1 mmol) were dissolved in 10% NaOH-EtOH (5 mL), it was stirred at room temperature for 9-10 h. After completion, 5 mL water was added to the reaction mixture. The separated solid compound was filtered and washed with water. It was purified by crystallization with methanol/chloroform or basic alumina column chromatography to give the desired compounds (3-13).The compounds (16-31) were prepared by the reaction of their corresponding aldehyde and ketone partners.

According to the analysis of related databases, 10040-98-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Marrapu, Vijay K.; Chaturvedi, Vinita; Singh, Shubhra; Singh, Shyam; Sinha, Sudhir; Bhandari, Kalpana; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4302 – 4310;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 10040-98-9, The chemical industry reduces the impact on the environment during synthesis 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, I believe this compound will play a more active role in future production and life.

A mixture of malonitrile (60.0 mg, 0.90 mmol) and 4-(1H-imidazol-1- yl)benzaldehyde (155.0 mg, 0.90 mmol) in anhydrous ethanol ( 4.0 mL) was charged with N- methylmorpholine (0.1 mL, 0.90 mmol) for 2 minutes. To the mixture was added 3-(4- methoxyphenyl)-1-methyl-1H-pyrazol-5(4H)-one (185.0 mg, 0.90 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and off white solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 48 as an off white solid (360 mg, 94%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 8.18 (s, 1H), 7.68 (s, 1H), 7.52-7.46 (m, 4H), 7.27 (d, J = 8.0 Hz, 2H), 7.13 (s, 2H), 7.06 (s, 1H), 6.78 (d, J = 8.0 Hz, 2H), 5.06 (s, 1H), 3.77 (s, 3H), 3.69 (s, 3H). MS (ESI): Calcd for C24H20N6O2: 424, found: 424 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Imidazol-1-yl-benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; YU, Chengzhi; POLAT, Tulay; YAN, Chao; RABIZADEH, Shahrooz; THEODORESCU, Daniel; (108 pag.)WO2016/205460; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, A new synthetic method of this compound is introduced below., Computed Properties of C10H8N2O

A mixture of malonitrile (60.0 mg, 0.9 mmol) and 4-(1H-imidazol-1-yl)benzaldehyde (155.0 mg, 0.9 mmol) in anhydrous ethanol ( 4.0 mL) was charged with N-methylmorpholine (0.1 mL, 0.9 mmol) for 2 minutes. To the mixture was added 3-cyclopentyl-1-methyl-1H- pyrazol-5(4H)-one (150.0 mg, 0.9 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and off white solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 18 as an off white solid (246 mg, 70%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 8.24 (s, 1H), 7.73 (s, 1H), 7.59 (d, J = 8.0 Hz, 2H), 7.30 (d, J = 8.0 Hz, 2H), 7.10-7.08 (d, J = 8.0 Hz, 3H), 4.67 (s, 1H), 3.63 (s, 3H), 2.48 (m, 1H), 1.76-1.28 (m, 8H). MS (ESI): Calcd for C25H18N6O2: 386, found: 387 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; YU, Chengzhi; POLAT, Tulay; YAN, Chao; RABIZADEH, Shahrooz; THEODORESCU, Daniel; (108 pag.)WO2016/205460; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem